Валеология: Здоровье, Болезнь, Выздоровление. 2019; : 23-27
СОВРЕМЕННЫЕ АСПЕКТЫ ИЗУЧЕНИЯ МИКРОБИОЦЕНОЗА ПОЛОСТИ РТА В РАЗВИТИИ РЕВМАТОИДНОГО АРТРИТА
Аннотация
Ревматоидный артрит (РА) - это системное аутоиммунное заболевание, вызываемое как генетическими факторами, так и факторами окружающей среды. Частота РА составляет 1 % в мировой популяции. В случае отсутствия своевременной диагностики и лечения данное заболевание в большинстве случаев приводит к инвалидизации в трудоспособном возрасте, а также к летальному исходу в результате внесуставных поражений и осложнений. В последние годы исследователи сосредоточились на изучении микробиоценоза, который, как считается, является агентом окружающей среды, влияющим на развитие РА, методом секвенирования 16SrРНК. В данной статье представлен обзор зарубежной и отечественной литературы по исследованию роли микробиоценоза в целом, и, в частности микробиоценоза полости рта в развитии РА . В результате проведенного обзора продемонстрирована актуальность и высокая практическая значимость изучаемого вопроса.
Список литературы
1. Majithia V., Geraci S. A. Rheumatoid Arthritis: Diagnosis and Management // Am. J. Med. 2007. Vol. 120, № 11. P. 936–939.
2. Scott D. L., Wolfe F., Huizinga T. W. J. Rheumatoid arthritis // Lancet (London, England). 2010. Vol. 376, № 9746. P. 1094–1108.
3. Eduardo G. et al. Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans // J. Clin. Med. Rev. 2019. Vol. 8,1309.
4. Алексеев, В. В. Особенности хронического болевого синдрома при ревматоидном артрите / В. В. Алексеев. - Л. врач. – 2011. - № 4.- С. 3-40.
5. Кундер Е. В.. Ревматоидный артрит: учеб.-метод. пособие / Е. В. Кундер [и др.] – Минск, 2014. – С. 6.
6. Korczowska I. Rheumatoid arthritis susceptibility genes: An overview // World J. Orthop. 2014. Vol. 5, № 4. P. 544–549.
7. Liu L. et al. MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1 // Cell. Mol. Biol. Lett. Cellular & Molecular Biology Letters, 2019. Vol. 24, № 1. P. 1–14.
8. Catrina A. I. et al. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis // Nature Reviews Rheumatology. Nature Publishing Group, 2017. Vol. 13, № 2. P. 79–86.
9. Okada Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery // Nature. 2014. Vol. 506, № 7488. P. 376–381.
10. Stahl E. A. et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci // Nat. Genet. 2010. Vol. 42, № 6. P. 508–514.
11. Fuggle N. R. et al. Hand to mouth: A systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis // Front. Immunol. Frontiers Media S. A., 2016. Vol. 7, № MAR.
12. Prodan A., Levin E., Nieuwdorp M. Does disease start in the mouth, the gut or both?: Oral bacteria colonize the gut more frequently than previously thought // Elife. eLife Sciences Publications Ltd, 2019. Vol. 8.
13. Wade W. G. The oral microbiome in health and disease // Pharmacol. Res. 2013. Vol. 69, № 1. P. 137–143.
14. Voigt A. Y. et al. Temporal and technical variability of human gut metagenomes // Genome Biol. Bio Med Central Ltd., 2015. Vol. 16, № 1.
15. Schloissnig S. et al. Genomic variation landscape of the human gut microbiome // Nature. 2013. Vol. 493, № 7430. P. 45–50.
16. Nikitakis N. G. et al. The autoimmunity–oral microbiome connection // Oral Dis.2017.Vol. 23, № 7. P. 828–839.
17. Chopra M. et al. Salivary immunoglobulin A in rheumatoid arthritis (RA) with focus on dental caries: A cross-sectional study // Clin. Rheumatol. 2012. Vol. 31, № 2. P. 247–250.
18. Demoruelle M. K., Deane K. D., Holers V. M. When and where does inflammation begin in rheumatoid arthritis? // Current Opinion in Rheumatology. 2014. Vol. 26, № 1. P. 64–71.
19. Svärd A. et al. Salivary IgA antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis // Immunobiology. 2013. Vol. 218, № 2. P. 232–237.
20. Колотова Н. Н. Иммунологические показатели ротовой жидкости у больных ревматоидным артритом / Н. Н. Колотова [и др.] // Уральский медицинский журнал. - 2012. -№ 8 (100). - С. 8-12.
21. Kumar P. S. From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease // Journal of Physiology. Blackwell Publishing Ltd, 2017. Vol. 595, № 2. P. 465–476.
22. Helenius L. M. J. et al. Oral and salivary parameters in patients with rheumatic diseases // Acta Odontol. Scand. 2005. Vol. 63, № 5. P. 284–293.
23. Nieten M. M. J. et al. Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis // Ann. Rheum. Dis. 2005. Vol. 64, № 8. P. 1199–1204.
24. Ogrendik M. Rheumatoid arthritis is linked to oral bacteria: Etiological association // Mod. Rheumatol. 2009. Vol. 19, № 5. P. 453–456.
25. Scher J. U. et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis // Arthritis Rheum. 2012. Vol. 64, № 10. P. 3083–3094.
26. Scher J. U., Bretz W. A., Abramson S. B. Periodontal disease and subgingival microbiota as contributors for rheumatoid arthritis pathogenesis: Modifiable risk factors? // Current Opinion in Rheumatology. Lippincott Williams and Wilkins, 2014. Vol. 26, № 4. P. 424–429.
27. Eriksson K. et al. Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis // J. Clin. Med. MDPI AG, 2019. Vol. 8, № 5. P. 630.
28. Pinho M. de N. et al. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment // Braz. Dent. J. Associacao Brasileira de Divulgacao Cientifica, 2009. Vol. 20, № 5. P. 355–364.
29. Straka M. et al. Associations between marginal periodontitis and rheumatoid arthritis // Neuro Endocrinol. Lett. 2012. Vol. 33, № 1. P. 16–20.
30. Hitchon C. A. et al. Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives // J. Rheumatol. 2010. Vol. 37, № 6. P. 1105–1112.
31. Lappin D. F. et al. Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres // J. Clin. Periodontol. 2013. Vol. 40, № 10. P. 907–915.
32. Mikuls T. R. et al. Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis // Arthritis Rheumatol. John Wiley and Sons Inc., 2014. Vol. 66, № 5. P. 1090–1100.
33. Kurkó J. et al. Genetics of rheumatoid arthritis - A comprehensive review // Clin. Rev. Allergy Immunol. 2013. Vol. 45, № 2. P. 170–179.
34. Chen B. et al. Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening // Sci. Rep. 2018. Vol. 8, № 1. P. 1–8.
35. Maeda Y., Takeda K. Role of Gut Microbiota in Rheumatoid Arthritis // J. Clin. Med. MDPI AG, 2017. Vol. 6, № 6. P. 60.
36. Maeda Y. et al. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine // Arthritis Rheumatol. John Wiley and Sons Inc., 2016. Vol. 68, № 11. P. 2646–2661.
37. Marietta E. V. et al. Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice // Arthritis Rheumatol. John Wiley and Sons Inc., 2016. Vol. 68, № 12. P. 2878–2888.
38. Zhang X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment // Nat. Med. Nature Publishing Group, 2015. Vol. 21, № 8. P. 895–905.
39. Vaahtovuo J. et al. Fecal microbiota in early rheumatoid arthritis. // J. Rheumatol. 2008. Vol. 35, № 8. P. 1500–1505.
40. Jeong Y. et al. Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis // J. Clin. Med. 2019. Vol. 8, № 5. P. 693.
41. Konig M. F. et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis // Sci. Transl. Med. American Association for the Advancement of Science, 2016. Vol. 8, № 369.
42. Mikuls T. R. et al. The subgingival microbiome in patients with established rheumatoid arthritis // Rheumatol. (United Kingdom). 2018. Vol. 57, № 7. P. 1162–1172.
43. Зияева Ш. Т. Особенности микробиоценоза кишечника у больных с ревматоидным артритом, деформирующим остеоартрозом, первичной подагрой и влияние пробиотикотерапии на клиническое течение болезни / Ш. Т. Зияева // Экспериментальная и клиническая гастроэнтерология. – Выпуск 136. – № 12. – 2016.
44. Гульнева М. Ю. Особенности микробиоценоза кишечника, верхних дыхательных и мочевыводящих путей при ОА, РА, СКВ: Автореферат / М. Ю. Гульнева. – Москва, 2017.
45. Kushugulova A. et al. Metagenomic analysis of gut microbial communities from a Central Asian population // BMJ Open. BMJ Publishing Group, 2018. Vol. 8. № 7.
46. Algazina T. et al. Features of microbiota in psoriatic disease: from skin and gut perspectives (review) // Georgian Med. News. 2019. № 287. P. 98–104.
Valeology: Health - Illnes - recovery. 2019; : 23-27
CURRENT ASPECTS OF THE STUDY OF ORAL MICROBIOCENOSIS IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS
Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and environmental factors. The incidence of RA is 1% in the global population. In the absence of timely diagnosis and treatment, this disease in most cases leads to disability in working age, as well as to death as a result of extra-articular manifestations and complications. In recent years, researchers have focused on studying microbiocenosis, which is considered to be an environmental agent contributing to the development of RA, using 16SrRNA sequencing. This article presents a review of foreign and domestic literature on the study of the role of microbiocenosis in general, and particularly the role of oral cavity microbiocenosis in the development of RA . As a result of the review the relevance and high practical importance of the investigated issue is demonstrated.
References
1. Majithia V., Geraci S. A. Rheumatoid Arthritis: Diagnosis and Management // Am. J. Med. 2007. Vol. 120, № 11. P. 936–939.
2. Scott D. L., Wolfe F., Huizinga T. W. J. Rheumatoid arthritis // Lancet (London, England). 2010. Vol. 376, № 9746. P. 1094–1108.
3. Eduardo G. et al. Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans // J. Clin. Med. Rev. 2019. Vol. 8,1309.
4. Alekseev, V. V. Osobennosti khronicheskogo bolevogo sindroma pri revmatoidnom artrite / V. V. Alekseev. - L. vrach. – 2011. - № 4.- S. 3-40.
5. Kunder E. V.. Revmatoidnyi artrit: ucheb.-metod. posobie / E. V. Kunder [i dr.] – Minsk, 2014. – S. 6.
6. Korczowska I. Rheumatoid arthritis susceptibility genes: An overview // World J. Orthop. 2014. Vol. 5, № 4. P. 544–549.
7. Liu L. et al. MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1 // Cell. Mol. Biol. Lett. Cellular & Molecular Biology Letters, 2019. Vol. 24, № 1. P. 1–14.
8. Catrina A. I. et al. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis // Nature Reviews Rheumatology. Nature Publishing Group, 2017. Vol. 13, № 2. P. 79–86.
9. Okada Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery // Nature. 2014. Vol. 506, № 7488. P. 376–381.
10. Stahl E. A. et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci // Nat. Genet. 2010. Vol. 42, № 6. P. 508–514.
11. Fuggle N. R. et al. Hand to mouth: A systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis // Front. Immunol. Frontiers Media S. A., 2016. Vol. 7, № MAR.
12. Prodan A., Levin E., Nieuwdorp M. Does disease start in the mouth, the gut or both?: Oral bacteria colonize the gut more frequently than previously thought // Elife. eLife Sciences Publications Ltd, 2019. Vol. 8.
13. Wade W. G. The oral microbiome in health and disease // Pharmacol. Res. 2013. Vol. 69, № 1. P. 137–143.
14. Voigt A. Y. et al. Temporal and technical variability of human gut metagenomes // Genome Biol. Bio Med Central Ltd., 2015. Vol. 16, № 1.
15. Schloissnig S. et al. Genomic variation landscape of the human gut microbiome // Nature. 2013. Vol. 493, № 7430. P. 45–50.
16. Nikitakis N. G. et al. The autoimmunity–oral microbiome connection // Oral Dis.2017.Vol. 23, № 7. P. 828–839.
17. Chopra M. et al. Salivary immunoglobulin A in rheumatoid arthritis (RA) with focus on dental caries: A cross-sectional study // Clin. Rheumatol. 2012. Vol. 31, № 2. P. 247–250.
18. Demoruelle M. K., Deane K. D., Holers V. M. When and where does inflammation begin in rheumatoid arthritis? // Current Opinion in Rheumatology. 2014. Vol. 26, № 1. P. 64–71.
19. Svärd A. et al. Salivary IgA antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis // Immunobiology. 2013. Vol. 218, № 2. P. 232–237.
20. Kolotova N. N. Immunologicheskie pokazateli rotovoi zhidkosti u bol'nykh revmatoidnym artritom / N. N. Kolotova [i dr.] // Ural'skii meditsinskii zhurnal. - 2012. -№ 8 (100). - S. 8-12.
21. Kumar P. S. From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease // Journal of Physiology. Blackwell Publishing Ltd, 2017. Vol. 595, № 2. P. 465–476.
22. Helenius L. M. J. et al. Oral and salivary parameters in patients with rheumatic diseases // Acta Odontol. Scand. 2005. Vol. 63, № 5. P. 284–293.
23. Nieten M. M. J. et al. Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis // Ann. Rheum. Dis. 2005. Vol. 64, № 8. P. 1199–1204.
24. Ogrendik M. Rheumatoid arthritis is linked to oral bacteria: Etiological association // Mod. Rheumatol. 2009. Vol. 19, № 5. P. 453–456.
25. Scher J. U. et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis // Arthritis Rheum. 2012. Vol. 64, № 10. P. 3083–3094.
26. Scher J. U., Bretz W. A., Abramson S. B. Periodontal disease and subgingival microbiota as contributors for rheumatoid arthritis pathogenesis: Modifiable risk factors? // Current Opinion in Rheumatology. Lippincott Williams and Wilkins, 2014. Vol. 26, № 4. P. 424–429.
27. Eriksson K. et al. Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis // J. Clin. Med. MDPI AG, 2019. Vol. 8, № 5. P. 630.
28. Pinho M. de N. et al. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment // Braz. Dent. J. Associacao Brasileira de Divulgacao Cientifica, 2009. Vol. 20, № 5. P. 355–364.
29. Straka M. et al. Associations between marginal periodontitis and rheumatoid arthritis // Neuro Endocrinol. Lett. 2012. Vol. 33, № 1. P. 16–20.
30. Hitchon C. A. et al. Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives // J. Rheumatol. 2010. Vol. 37, № 6. P. 1105–1112.
31. Lappin D. F. et al. Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres // J. Clin. Periodontol. 2013. Vol. 40, № 10. P. 907–915.
32. Mikuls T. R. et al. Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis // Arthritis Rheumatol. John Wiley and Sons Inc., 2014. Vol. 66, № 5. P. 1090–1100.
33. Kurkó J. et al. Genetics of rheumatoid arthritis - A comprehensive review // Clin. Rev. Allergy Immunol. 2013. Vol. 45, № 2. P. 170–179.
34. Chen B. et al. Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening // Sci. Rep. 2018. Vol. 8, № 1. P. 1–8.
35. Maeda Y., Takeda K. Role of Gut Microbiota in Rheumatoid Arthritis // J. Clin. Med. MDPI AG, 2017. Vol. 6, № 6. P. 60.
36. Maeda Y. et al. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine // Arthritis Rheumatol. John Wiley and Sons Inc., 2016. Vol. 68, № 11. P. 2646–2661.
37. Marietta E. V. et al. Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice // Arthritis Rheumatol. John Wiley and Sons Inc., 2016. Vol. 68, № 12. P. 2878–2888.
38. Zhang X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment // Nat. Med. Nature Publishing Group, 2015. Vol. 21, № 8. P. 895–905.
39. Vaahtovuo J. et al. Fecal microbiota in early rheumatoid arthritis. // J. Rheumatol. 2008. Vol. 35, № 8. P. 1500–1505.
40. Jeong Y. et al. Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis // J. Clin. Med. 2019. Vol. 8, № 5. P. 693.
41. Konig M. F. et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis // Sci. Transl. Med. American Association for the Advancement of Science, 2016. Vol. 8, № 369.
42. Mikuls T. R. et al. The subgingival microbiome in patients with established rheumatoid arthritis // Rheumatol. (United Kingdom). 2018. Vol. 57, № 7. P. 1162–1172.
43. Ziyaeva Sh. T. Osobennosti mikrobiotsenoza kishechnika u bol'nykh s revmatoidnym artritom, deformiruyushchim osteoartrozom, pervichnoi podagroi i vliyanie probiotikoterapii na klinicheskoe techenie bolezni / Sh. T. Ziyaeva // Eksperimental'naya i klinicheskaya gastroenterologiya. – Vypusk 136. – № 12. – 2016.
44. Gul'neva M. Yu. Osobennosti mikrobiotsenoza kishechnika, verkhnikh dykhatel'nykh i mochevyvodyashchikh putei pri OA, RA, SKV: Avtoreferat / M. Yu. Gul'neva. – Moskva, 2017.
45. Kushugulova A. et al. Metagenomic analysis of gut microbial communities from a Central Asian population // BMJ Open. BMJ Publishing Group, 2018. Vol. 8. № 7.
46. Algazina T. et al. Features of microbiota in psoriatic disease: from skin and gut perspectives (review) // Georgian Med. News. 2019. № 287. P. 98–104.
