Инфекция и иммунитет. 2015; 5: 79-84
КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ СЫВОРОТОЧНЫХ УРОВНЕЙ ЦИТОКИНОВ ПРИ ВЕТРЯНОЙ ОСПЕ У ДЕТЕЙ
https://doi.org/10.15789/2220-7619-2015-1-79-84Аннотация
У 74 детей с разным течением ветряной оспы определили концентрации цитокинов IL-1β, IL-8, IL-6, IFNα, IFNγ, IL-4, IL-10 в сыворотке крови методом ИФА. Ветряная оспа средней степени тяжести сопровождалась значительным подъемом уровней IL-1β, IL-8, IFNα, IFNγ и IL-10, тогда как тяжелое течение инфекции ассоциировано с редукцией ответа цитокинов. Развитие ветряночных энцефалитов сопровождалось подъемом уровней IL-1β, IL-6, IFNγ и IL-10 на 2-й неделе болезни.
Список литературы
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Russian Journal of Infection and Immunity. 2015; 5: 79-84
CLINICAL SIGNIFICANCE OF CYTOKINES SERUM LEVELS IN CHILDREN WITH CHICKEN POX
https://doi.org/10.15789/2220-7619-2015-1-79-84Abstract
The serum levels of cytokines IL-1β, IL-8, IL-6, IFNα, IFNγ, IL-4, IL-10 were tested in ELISA in 74 children with different courses of chicken pox. Moderate severity course of chicken pox was accompanied by significant increase of IL-1β, IL-8, IFNα, IFNγ, IL-10 levels, but severe course of infection was associated with cytokine response reduction. Manifestation of varicella-zoster virus encephalitis was accompanied by the rise of IL-1β, IL-6, IFNγ and IL-10 levels during the second week of disease.
References
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8. Desloges N., Schubert C., Wolff M., Rahaus M. Varicella-zoster virus infection induces the secretion of interleukin-8. Med. Microbiol. Immunol., 2008, vol. 197, no. 3, pp. 277–284.
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10. Lafon M., Megret F., Lafage M., Prehaud C. The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. J. Mol. Neurosci., 2006, vol. 29, no. 3, pp. 185–194.
11. MalavigeG.,JonesL.,KamaladasaS.,WijewickramaA.,SeneviratneS.,BlackA.,OggG.Viralload,clinicaldiseaseseverityand cellular immune responses in primary varicella zoster virus infection in Sri Lanka. PLOS One, 2008, vol. 3, no. 11, pp. e3789.
12. Ohfu M., Mazutaki M., Inoue S., Inoue T., Yasumoto S., Ogawa A., Tomoda Y., Tsuru N., Mitsudome A. Interleukin-6 in the cerebrospinal fluid of two patients with herpes zoster meningitis. No To Hattatsu, 2001, vol. 33, no. 3, pp. 270–275.
13. Yang M., Min K., Joe E. Multiple mechanisms that prevent excessive brain inflammation. J. Neurosci. Res., 2007, vol. 85, no. 11, pp. 2298–2305.
14. YuH.,ChenR.,HongK.,BongC.,LeeW.,KuoH.,YangK.IL-12-independentTh1polarizationinhumanmononuclearcells infected with varicella-zoster virus. Eur. J. Immunol., 2005, vol. 35, no. 12, pp. 3664–3672.
