Инфекция и иммунитет. 2021;
ВЗАИМОСВЯЗЬ МЕЖДУ RAS И COVID-19, КРАТКИЙ ОБЗОР ПОСЛЕДНИХ ДОКАЗАТЕЛЬСТВ
https://doi.org/10.15789/2220-7619-TCB-1613Аннотация
Коронавирус SARS-CoV-2 является причиной коронавирусной болезни (COVID-19), вызвавшей недавнюю глобальную пандемию, которая унесла тысячи жизней во всем мире и представляет собой проблему для здоровья, имеющую несколько прецедентов в истории человечества. Ангиотензин-конвертаза-2 (ACE-2) был идентифицирован как рецептор, который облегчает доступ к SARS-CoV-2 в клетках; данные показывают, что его концентрация варьируется на разных стадиях вирусной инфекции. Терапевтические агенты, модифицирующие ренин-ангиотензиновую систему (РАС), могут быть способны модулировать концентрацию ACE-2 и различных компонентов системы. В этой статье мы исследуем последние доказательства связи между использованием агентов, модифицирующих RAS, и заболеванием, вызванным коронавирусом 2019 (COVID-19), вызванным SARS-CoV-2. Наше исследование и критическое исследование литературы не предлагают прекращения лечения ACEIs/ARBs в клинической практике, поскольку для этого отсутствуют надежные доказательства. Тем не менее, мы рекомендуем провести дальнейшие хорошо структурированные эпидемиологические исследования, посвященные этому деликатному вопросу, которые могут дать новые важные предложения по внедрению руководящих принципов терапии.
Список литературы
1. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS ChemNeuroscienc. 2020 Mar 13. doi: 10.1021/acschemneuro.0c00122
2. Liu Z, Xiao X, Wei X, Li J, Yang , Tan H, Zhu J, Zhang Q, Wu J, Liu L.J Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV. MedVirol. 2020 Feb 26. doi: 10.1002/jmv.25726. 2.
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10. Antonio Vitiello, Francesco Ferrara Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know European Journal of Pharmacology 15 July 2000
11. Fosbøl EL, Butt JH, Østergaard L, Andersson C, Selmer C, Kragholm K, Schou M, Phelps M, Gislason GH, Gerds TA, Torp-Pedersen C, Køber L. Association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with COVID-19 diagnosis and mortality. JAMA Published online June 2020; 19: 168
12. Reynolds HR, Adhikari S, Pulgarin C, Troxel AB, Iturrate E, Johnson SB, Hausvater A, Newman JD, Berger JS, Bangalore S, Katz SD, Fishman GI, Kunichoff D, Chen Y, Ogedegbe G, HochmanJS.Renin-angiotensin-aldosterone system inhibitors and risk of COVID-19. N Engl J Med 2020; 382: 2441–2448.
13. Zhang P, Zhu L, Cai J, Lei F, Qin J-J, Xie J, Liu Y-M, Zhao Y-C, Huang X, Lin L, Xia M, Chen M-M, Cheng X, Zhang X, Guo D, Peng Y, Ji X-Y, Chen J, She Z-G, Wang Y, Xu Q, Tan R, Wang H, Lin J, Luo P, Fu S, Cai H, Ye P, Xiao B, Mao W, Liu L, Yan Y, Liu M, Chen M, Zhang X-J, Wang X, Touyz RM, Xia J, Zhang B-H, Huang X, Yuan X,RohitL, Liu PP, Li H. Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circ Res 2020; 126: 1671-1681
14. Sama IE, Ravera A, Santema BT, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020;41(19):1810-1817. doi:10.1093/eurheartj/ehaa373
Russian Journal of Infection and Immunity. 2021;
The correlation between RAS and COVID-19, short review of the latest evidence
https://doi.org/10.15789/2220-7619-TCB-1613Abstract
Coronavirus SARS-CoV-2 is responsible for the Coronavirus disease (COVID-19) cause of the recent global pandemic, which is causing thousands of deaths worldwide and represents a health challenge with few precedents in human history. The angiotensin 2 conversion enzyme (ACE-2) has been identified as the receptor that facilitates access to SARS-CoV-2 in cells; evidence shows that its concentration varies during the various stages of viral infection. Therapeutic agents modifying the renin-angiotensin system (RAS) may be able to modulate the concentration of ACE-2 and the various components of the system. In this article we examine the latest evidence on the association between the use of RAS modifying agents and coronavirus 2019 (COVID-19) disease caused by SARS-CoV-2. Our investigation and critical literature research does not suggest discontinuation of ACEIs/ARBs treatment in clinical practice as there is a lack of robust evidence. However, we recommend further well-structured epidemiological studies investigating this sensitive issue that may provide important new suggestions for implementing guidelines.
Coronavirus SARS-CoV-2 is responsible for the Coronavirus disease (COVID-19) cause of the recent global pandemic, which is causing thousands of deaths worldwide and represents a health challenge with few precedents in human history. The angiotensin 2 conversion enzyme (ACE-2) has been identified as the receptor that facilitates access to SARS-CoV-2 in cells; evidence shows that its concentration varies during the various stages of viral infection. Therapeutic agents modifying the renin-angiotensin system (RAS) may be able to modulate the concentration of ACE-2 and the various components of the system. In this article we examine the latest evidence on the association between the use of RAS modifying agents and coronavirus 2019 (COVID-19) disease caused by SARS-CoV-2. Our investigation and critical literature research does not suggest discontinuation of ACEIs/ARBs treatment in clinical practice as there is a lack of robust evidence. However, we recommend further well-structured epidemiological studies investigating this sensitive issue that may provide important new suggestions for implementing guidelines.
References
1. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS ChemNeuroscienc. 2020 Mar 13. doi: 10.1021/acschemneuro.0c00122
2. Liu Z, Xiao X, Wei X, Li J, Yang , Tan H, Zhu J, Zhang Q, Wu J, Liu L.J Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV. MedVirol. 2020 Feb 26. doi: 10.1002/jmv.25726. 2.
3. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19).StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;2020 Mar 8.
4. Ashour HM, Elkhatib WF, Rahman MM, Elshabrawy HA. Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks. Pathogens. 2020 Mar 4;9(3). pi: E186.
5. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444–48.
6. Walls AC ,Park YJ ,Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell.2020 Mar 6. pii: S0092-8674(20)30262-2
7. . Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181:894–904.
8. Zhang, H., Penninger, J.M., Li, Y. et al. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med (2020).
9. Bavishi, C., Bangalore, S., Messerli, F.H., 2016. Renin angiotensin aldosterone system inhibitors in hypertension: is there evidence for benefit independent of blood pressure reduction? Prog. Cardiovasc. Dis. 59, 253–261.
10. Antonio Vitiello, Francesco Ferrara Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know European Journal of Pharmacology 15 July 2000
11. Fosbøl EL, Butt JH, Østergaard L, Andersson C, Selmer C, Kragholm K, Schou M, Phelps M, Gislason GH, Gerds TA, Torp-Pedersen C, Køber L. Association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with COVID-19 diagnosis and mortality. JAMA Published online June 2020; 19: 168
12. Reynolds HR, Adhikari S, Pulgarin C, Troxel AB, Iturrate E, Johnson SB, Hausvater A, Newman JD, Berger JS, Bangalore S, Katz SD, Fishman GI, Kunichoff D, Chen Y, Ogedegbe G, HochmanJS.Renin-angiotensin-aldosterone system inhibitors and risk of COVID-19. N Engl J Med 2020; 382: 2441–2448.
13. Zhang P, Zhu L, Cai J, Lei F, Qin J-J, Xie J, Liu Y-M, Zhao Y-C, Huang X, Lin L, Xia M, Chen M-M, Cheng X, Zhang X, Guo D, Peng Y, Ji X-Y, Chen J, She Z-G, Wang Y, Xu Q, Tan R, Wang H, Lin J, Luo P, Fu S, Cai H, Ye P, Xiao B, Mao W, Liu L, Yan Y, Liu M, Chen M, Zhang X-J, Wang X, Touyz RM, Xia J, Zhang B-H, Huang X, Yuan X,RohitL, Liu PP, Li H. Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circ Res 2020; 126: 1671-1681
14. Sama IE, Ravera A, Santema BT, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020;41(19):1810-1817. doi:10.1093/eurheartj/ehaa373
