Инфекция и иммунитет. 2020; 10: 789-791
Партенолид: возможное лекарство от COVID-19
https://doi.org/10.15789/2220-7619-PSD-1509Аннотация
Новый коронавирус тяжелого острого респираторного синдрома (SARS-CoV-2) вызывает развитие респираторного дистресс-синдрома, являющегося основной причиной смерти пациентов. Одним из эффективных методов снижения воздействия этого вируса является партенолид (PN). Партенолид — сесквитерпе-новый лактон, содержащийся в лекарственных растениях, способный подавлять ряд провоспалительных сигнальных каскадов, в частности АТФ-азную активность инфламмасомы NLRP3. Учитывая его способность блокировать проведение воспалительных сигналов и повышенный уровень сывороточного цитокина IL-1β (как суррогатного маркера активации NLRP3) у пациентов с COVID-19, мы полагаем, что Партенолид мог бы быть эффективен при лечении COVID-19.
Список литературы
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6. Juliana C., Fernandes-Alnemri T., Wu J., Datta P., Solorzano L., Yu J.W., Meng R., Quong A.A., Latz E., Scott C.P., Alnemri E.S. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J. Biol. Chem., 2010, vol. 285, no. 13,pp. 9792-9802. doi: 10.1074/jbc.M109.082305
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9. Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med., 2020, vol. 46, no. 5, pp. 846-848. doi: 10.1007/s00134-020-05991-x
10. Smolinski A.T., Pestka J.J. Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J. Inflamm., 2005, no. 2: 6. doi: 10.1186/1476-9255-2-6
11. Wang C., Horby P.W., Hayden F.G., Gao G.F. A novel coronavirus outbreak of global health concern. Lancet, 2020, vol. 395, no. 10223, pp. 470-473. doi: 10.1016/S0140-6736(20)30185-9
Russian Journal of Infection and Immunity. 2020; 10: 789-791
Parthenolide: suggested drug for COVID-19
https://doi.org/10.15789/2220-7619-PSD-1509Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the 2019 novel coronavirus (2019-nCoV) that causes acute respiratory distress syndrome (ARDS) which is the main reason for patients mortality. One of the effective treatments to reduce the effects of this virus is parthenolide (PN). Parthenolide is a sesquiterpene lactone found in medicinal plants. It can inhibit several pro-inflammatory signaling pathways, in particular the ATPase activity of NLRP3. Based on its ability to suppress inflammatory signal transduction and elevated level of serum IL-1β (a surrogate marker for NLRP3 activation) in COVID-19 patients, we suggest that PN could be potentiallyeffective for the treatment of COVID-19.
References
1. Abad M.J., Guerra J.A., Bermejo P., Govil J., Singh V.K., Mishra S.K. Phytochemistry and pharmacology of Tanacetum: recent developments (2008).
2. Bauernfeind F.G., Horvath G., Stutz A., Alnemri E.S., MacDonald K., Speert D., Fernandes-Alnemri T., Wu J., Monks B.G., Fitzgerald K.A., Hornung V., Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol., 2009, vol. 183, no. 2, pp. 787—791. doi: 10.4049/jimmunol.0901363
3. Dai Y., Guzman M.L., Chen S., Wang L., Yeung S.K., Pei X.Y., Dent P., Jordan C.T., Grant S. The NF (Nuclear factor)-KB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells. Br. J. Haematol., 2010, vol. 151, no. 1, pp. 70—83. doi: 10.1111/j.1365-2141.2010.08319.x
4. Dammann K., Khare V., Gasche C. Tracing PAKs from GI inflammation to cancer. Gut, 2014, vol. 63, no. 7, pp. 1173—1184. doi: 10.1136/gutjnl-2014-306768
5. Fitzgerald K.N. A few additional treatment possibilities for COVID19 (SARS Cov-2) addressing furin-like cleavage and pyropto-sis (caspase-1 activation of inflammasome NLRP3). URL: https://www.drkarafitzgerald.com/2020/03/25/a-few-additional-treat-ment-possibilities-in-covid19-sars-cov-2-addressing-furin-like-cleavage-and-pyroptosis-caspacin-1-activation-of-inflammasome-nlrp3 (10.09.2020)
6. Juliana C., Fernandes-Alnemri T., Wu J., Datta P., Solorzano L., Yu J.W., Meng R., Quong A.A., Latz E., Scott C.P., Alnemri E.S. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J. Biol. Chem., 2010, vol. 285, no. 13,pp. 9792-9802. doi: 10.1074/jbc.M109.082305
7. Martinon F., Mayor A., Tschopp J. The inflammasomes: guardians of the body. Annu. Rev. Immunol., 2009, vol. 27, pp. 229-265.
8. Maruta H., He H. A mini-review for COVID-19 issue (2020). URL: http://apitherapy.com/wp-content/uploads/2020/06/Propolis-melatonin-artemisinin-and-other-substances-as-PAK1-blocking-Therapy-of-Pandemic-Coronaviral-Infection-2020-Australia.pdf (20.08.2020)
9. Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med., 2020, vol. 46, no. 5, pp. 846-848. doi: 10.1007/s00134-020-05991-x
10. Smolinski A.T., Pestka J.J. Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J. Inflamm., 2005, no. 2: 6. doi: 10.1186/1476-9255-2-6
11. Wang C., Horby P.W., Hayden F.G., Gao G.F. A novel coronavirus outbreak of global health concern. Lancet, 2020, vol. 395, no. 10223, pp. 470-473. doi: 10.1016/S0140-6736(20)30185-9
