Инфекция и иммунитет. 2013; 3: 371-375
ВЗАИМОСВЯЗЬ ПОЛИМОРФИЗМОВ IL-28β С ЭФФЕКТИВНОСТЬЮ СОПУТСТВУЮЩЕЙ ТЕРАПИИ ВИЧ У ПАЦИЕНТОВ С КОИНФЕКЦИЕЙ ВИЧ/ВГС ПРИ ЛЕЧЕНИИ ГЕПАТИТА С
https://doi.org/10.15789/2220-7619-2013-4-371-375Аннотация
Резюме. Целью работы являлась оценка взаимосвязи полиморфизма rs8099917 IL-28β с изменением вирусной нагрузки ВИЧ и эффективностью высокоактивной антиретровирусной терапии при лечении хронического гепатита С у ВИЧ-инфицированных пациентов. В исследовании принимало участие 80 ВИЧ-инфицированных пациентов с вирусным гепатитом С, проходивших комплексное лечение пегилированным IFNα и рибавирином и получающих сопутствующую терапию ВИЧ. Молекулярно-генетический анализ полиморфизма гена IL 28b (rs8099917) и определение вирусной нагрузки ВИЧ проводили методом полимеразной цепной реакции с детекцией в режиме «реального времени». У 56,25% пациентов при сочетанной терапии ВИЧ и гепатита С при исследовании количества CD4 Т-лимфоцитов было выявлено значимое снижение количества CD4 Т-лимфоцитов в группах с генотипами ТТ и TG и уровня вирусной нагрузки РНК ВИЧ в группе с генотипом ТТ на всем протяжении лечения. Были сделаны выводы, что у ВИЧ-инфицированных пациентов, получающих сопутствующую терапию ВИЧ на протяжении лечения вирусного гепатита С, полиморфизм rs8099917 гена IL-28β влияет на динамику вирусной нагрузки РНК ВИЧ и может в совокупности с другими факторами использоваться как предиктор эффективности высокоактивной антиретровирусной терапии.
Список литературы
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Russian Journal of Infection and Immunity. 2013; 3: 371-375
ASSOCIATION BEETWEEN IL-28β POLYMORPHISMS AND EFFECTIVENESS OF CONCOMITANT THERAPY OF HIV INFECTION IN PATIENTS WITH HCV/HIV CO-INFECTION DURING THE ANTIVIRAL THERAPY
https://doi.org/10.15789/2220-7619-2013-4-371-375Abstract
Abstract. The aim of the study was to evaluate the associations between the polymorphism rs8099917 IL-28β and changing of HIV viral load and the effectiveness of high active antiretroviral therapy during the treatment of chronic hepatitis C in HIV-infected patients. 80 HIV/HCV-infected patients were recruited in the study. Antiviral therapy was performed with pegylated interferon-α and ribavirin combined with concomitant HIV therapy. Polymerase chain method was used for the gene polymorphism IL 28b (rs8099917) and HIV viral load estimation. More than half (56.25%) patients treated with combined therapy showed a significant decrease in CD4 T-lymphocytes in TG- and TT-genotype groups. Furthermore, viral load of HIV RNA significantly declined in the group with TT genotype during the treatment. It was concluded that rs8099917 polymorphism of the gene IL-28β affects the dynamics of the HIV RNA viral load in HIV-infected patients receiving concomitant therapy for treatment of viral hepatitis C. Herewith, rs8099917 polymorphism combined with other factors can be used as a predictor of high active antiretroviral therapy effectiveness.
References
1. Arsent'eva N.A. Totolyan A.A., Semenov A.V. Rol' polimorfizma genov tsitokinov pri virusnom gepatite S // Infektsiya i immunitet. — 2012. — T. 2, № 4. — C. 687–698. Arsent`eva N.A. Totolyan A.A., Semenov A.V. Rol` polimorfizma genov tsitokinov pri virusnom gepatite C [The role of cytokine gene polymorphism in viral hepatitis C]. Infektsiya i immunitet — Infection and Immunity, 2012, vol. 2, no. 4, pp. 687–698.
2. Kravchenko A.V., Gankina N.Yu., Kanestri V.G. Osobennosti antiretrovirusnoi terapii pri sochetanii VICh-infektsii i khronicheskogo virusnogo gepatita // Farmateka. — 2008. — № 19 (173). — S. 10–17. Kravchenko A.V., Gankina N.Yu., Kanestri V.G. Osobennosti antiretrovirusnoy terapii pri sochetanii VICH-infektsii i khronicheskogo virusnogo gepatita [Special aspects antiretroviral combination therapy for HIV infection and chronic viral hepatitis]. Farmateka — Farmateka, 2008. no. 19 (173), pp. 10–17.
3. Alberti A.,Clumeck N., Collins S., Gerlich W., Lundgren J., Palù G., Reiss P., Thiebaut R., Weiland O., Yazdanpanah Y., Zeuzem S. (The ECC Jury). Short statement of the first European consensus conference on the treatment of chronic hepatitis B and C in HIV co-infected patients. J. Hepatol., 2005, vol. 42, no. 5, pp. 615–624.
4. Bica I., McGovern B., Dhar R., Stone D., McGowan K., Scheib R., Snydman D.R. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin. Infect. Dis., 2001, vol. 32, pp. 492–497.
5. Clarc P., Thompson A., McHutchison J. IL 28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future of personalized HCV therapies. Am. J. Gastroenterol., 2011, vol. 106, pp. 38–45.
6. Ge D., Fellay J., Thompson A.J., Simon J.S., Shianna K.V., Urban T.J., Heinzen E.L., Qiu P., Bertelsen A.H., Muir A.J., Sulkowski M., McHutchison J.G., Goldstein D.B. Genetic variation in IL-28B predicts hepatitis C treatment-induced viral clearance. Nature, 2009, vol. 461, pp. 399–401.
7. Kovaleva E.S. Association between IL-28β polymorphism and viral load of HIV RNA in patients with HCV/HIV co-infection during the antiviral therapy. Actual Problems of Experimental and Clinical Medicine: Proceedings of 71st opened scientific and practical conference for young scientists and students with international participation, 2013, pp. 160.
8. McHutchison J.G., Everson G.T., Gordon S.C., Jacobson I.M., Sulkowski M., Kauffman R., McNair L., Alam J., Muir A.J. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N. Engl. J. Med., 2009, vol. 360, pp. 1827–1838.
9. Romano K., Ali A., Schiffer C. Avoiding drug resistance against HCV NS3/4A protease inhibitors. Antiviral. Ther., 2010, vol. 15, suppl. 2, pp. 189–192.
10. Soriano V., Puoti M., Sulkowski M. Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV Internationals Panel. AIDS, 2007, vol. 21, pp. 1073–1089.
11. Thompson A.J., Muir A.J., Sulkowski M.S. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology, 2010, vol. 139, pp. 120–129.
12. Tural C., Solà R., Alvarez N.P., Moltó J., Sánchez M., Zamora A.M., Ornelas A., Laguno M., González J., von Wichmann M. Á., Téllez M.J., Paredes R., Clotet B. Effect of an induction period of pegylated interferon-α2a and ribavirin on early virological response in HIV-HCV-coinfected patients: results from the CORAL-2 study. Antivir. Ther., 2011, vol. 16, iss. 6, pp. 833–841.
