Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017; 16: 22-27
Алгоритм диагностики и выбор методов лечения различных форм гемангиом печени у детей
https://doi.org/10.24287/1726-1708-2017-16-1-22-27Аннотация
Список литературы
1. Поляев Ю.А., Нарбутов А.Г., Мыльников А.А., Гарбузов Р.В. Диагностика и лечение доброкачественных гиперваскулярных образований печени у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2014;1:25-33.
2. Поляев Ю.А., Постников С.С., Мыльников А.А., Нарбутов А.Г. Место пропранолола в лечении инфантильных гемангиом. Детская больница. 2012;4:46-48.
3. Boon L.M., Burrows P.E., Paltiel H.J., Lund D.P., Ezekowitz R.A., Folkman J. et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346-354.
4. Bosemani T., Puttgen K.B., Huisman T.A., Tekes A. Multifocal infantile hepatic hemangiomas-imaging strategy and response to treatment after propranolol and steroids including review of the literature. Eur J Pediatr. 2012;171(7):1023-1028.
5. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.
6. Cavalli R., Novotna V., Buffon R.B., Gelmetti C. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period. G Ital Dermatol Venereol. 2013;148(5):525-530.
7. Chen H., Lin X., Jin Y., Fan X., Li W., Ma G. et al. Deep infantile hemangiomas and early venous malformations: Differential diagnosis by 3D CT angiography. Ann Plast Surg. 2010;64(6):755-758.
8. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.
9. Dubois J., Garel L., Grignon A., David M., Laberge L., Filiatrault D. et al. Imaging of hemangiomas and vascular malformations in children. Acad Radiol. 1998;5(5):390-400.
10. McLean R.H., Moller J.H., Warwick W.J., Satran L., Lucas R.V. Jr. Multinodular hemangiomatosis of the liver in infancy. Pediatrics. 1972;49:563-573.
11. Erbay A., Sarialioglu F., Malbora B., Yildirim S.V., Varan B., Tarcan A. et al. Propranolol for infantile haemangiomas: a preliminary report on efficacy and safety in very low birthweight infants. Turk J Pediatr. 2010;52(5):450-456.
12. Holmdahl K. Cutaneous hemangiomas in premature and mature infants. Acta Paediatr. 1955;44(4):370-379.
13. Ishak K.G., Goodman Z.D., Stocker J.T. Benign mesenchymal tumors and pseudotumors. In: Rosai J., Sobin L., eds. Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. Washington, DC: Armed Forces Institute of Pathology; 2001:71-157.
14. Kassarjian A., Zurakowski D., Dubois J., Paltiel H.J., Fishman S.J., Burrows P.E. Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol. 2004;182(3):785-795.
15. Mason K.P., Koka B.V., Eldredge E.A., Fishman S.J., Burrows P.E. Perioperative considerations in a hypothyroid infant with hepatic haemangioma. Paediatr Anaesth. 2001;11(2):228-232.
16. Zhang Z., Chen H.J., Yang W.J., Bu H., Wei B., Long X.Y. et al. Infantile hepatic hemangioendothelioma in a Chinese population. World J Gastroenterol. 2010;16(36):4549-4557.
17. Mhanna A., Franklin W.H., Mancini A.J. Hepatic infantile hemangiomas treated with oral propranolol - а case series. Pediatr Dermatol. 2011;28(1):39-45.
18. Mo J.Q., Dimashkieh H.H., Bove K.E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular mal- formation with associated capillary proliferation. Hum Pathol. 2004;35(2):200-209.
19. Pratt G.A. Birthmarks in infants. AMA Arch Derm Syphilol. 1953;67(3):302-305.
20. Yeh I., Bruckne A.L., Sanchez R., Jeng M.R., Newell B.D., Frieden I.J. Diffuse infantile hepatic hemangiomas: а report of four cases successfully managed with medical therapy. Pediatr Dermatol. 2011;28(3):267-275
Pediatric Hematology/Oncology and Immunopathology. 2017; 16: 22-27
Diagnostic procedure and choice of treatment of various forms of liver hemangiomas in children
https://doi.org/10.24287/1726-1708-2017-16-1-22-27Abstract
Liver tumor can be identified in the child from the first days of life, and sometimes in the prenatal period. It is very important to differentiate hemangiomas from vascular malformations, especially in the first year of life. Total in Russian Children’s Clinacal Hospital and Dmitry Rogachev Federal Research Center of Paediatric Hematology, Oncology and Immunology for the period 2004−2016 were examined and treated 90 children. The main method of diagnosis: MSCT, MRI, Doppler ultrasound, angiography. Focal form revealed in 52 children (58%), multifocal 32 (35%), diffuse 6 patients (7%). Treatment methods include: propranolol therapy, endovascular occlusion and surgery. The choice of method occurred based on the type hemangiomas and age of the patient. Therapy of β-blockers was held 61 (67%) child with various forms of hemangiomas of the liver at the age from 1 month to 1 year 2 months. Endovascular treatment performed 38 patients (42%) between the ages of 3 months to 5 years. Endovascular occlusion is performed using the 3 main types of occlusive materials: beads, cylinders and Gianturko spirals. Surgery performed 17 patients (19%), including 1 patient revealed diffuse, multifocal in 3 and 13 focal form. In the group of drug treatment initial response to therapy of β-blockers was obtained in all patients. In the second group, after performing endovascular occlusion of hemangiomas, the reduction of the size of formations with a reduction of blood flow in them, followed by a gradual devolution of formations was observed in all patients. Today catamnesis is 9 years old, relapse is not revealed. In the group of surgical re-operation was required in any case, the relapse of the pathological process is also not observed. Thus, in patients with hepatic hemangiomas expedient selection of the most conservative and minimally invasive treatment.
References
1. Polyaev Yu.A., Narbutov A.G., Myl'nikov A.A., Garbuzov R.V. Diagnostika i lechenie dobrokachestvennykh gipervaskulyarnykh obrazovanii pecheni u detei. Rossiiskii vestnik detskoi khirurgii, anesteziologii i reanimatologii. 2014;1:25-33.
2. Polyaev Yu.A., Postnikov S.S., Myl'nikov A.A., Narbutov A.G. Mesto propranolola v lechenii infantil'nykh gemangiom. Detskaya bol'nitsa. 2012;4:46-48.
3. Boon L.M., Burrows P.E., Paltiel H.J., Lund D.P., Ezekowitz R.A., Folkman J. et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346-354.
4. Bosemani T., Puttgen K.B., Huisman T.A., Tekes A. Multifocal infantile hepatic hemangiomas-imaging strategy and response to treatment after propranolol and steroids including review of the literature. Eur J Pediatr. 2012;171(7):1023-1028.
5. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.
6. Cavalli R., Novotna V., Buffon R.B., Gelmetti C. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period. G Ital Dermatol Venereol. 2013;148(5):525-530.
7. Chen H., Lin X., Jin Y., Fan X., Li W., Ma G. et al. Deep infantile hemangiomas and early venous malformations: Differential diagnosis by 3D CT angiography. Ann Plast Surg. 2010;64(6):755-758.
8. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.
9. Dubois J., Garel L., Grignon A., David M., Laberge L., Filiatrault D. et al. Imaging of hemangiomas and vascular malformations in children. Acad Radiol. 1998;5(5):390-400.
10. McLean R.H., Moller J.H., Warwick W.J., Satran L., Lucas R.V. Jr. Multinodular hemangiomatosis of the liver in infancy. Pediatrics. 1972;49:563-573.
11. Erbay A., Sarialioglu F., Malbora B., Yildirim S.V., Varan B., Tarcan A. et al. Propranolol for infantile haemangiomas: a preliminary report on efficacy and safety in very low birthweight infants. Turk J Pediatr. 2010;52(5):450-456.
12. Holmdahl K. Cutaneous hemangiomas in premature and mature infants. Acta Paediatr. 1955;44(4):370-379.
13. Ishak K.G., Goodman Z.D., Stocker J.T. Benign mesenchymal tumors and pseudotumors. In: Rosai J., Sobin L., eds. Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. Washington, DC: Armed Forces Institute of Pathology; 2001:71-157.
14. Kassarjian A., Zurakowski D., Dubois J., Paltiel H.J., Fishman S.J., Burrows P.E. Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol. 2004;182(3):785-795.
15. Mason K.P., Koka B.V., Eldredge E.A., Fishman S.J., Burrows P.E. Perioperative considerations in a hypothyroid infant with hepatic haemangioma. Paediatr Anaesth. 2001;11(2):228-232.
16. Zhang Z., Chen H.J., Yang W.J., Bu H., Wei B., Long X.Y. et al. Infantile hepatic hemangioendothelioma in a Chinese population. World J Gastroenterol. 2010;16(36):4549-4557.
17. Mhanna A., Franklin W.H., Mancini A.J. Hepatic infantile hemangiomas treated with oral propranolol - a case series. Pediatr Dermatol. 2011;28(1):39-45.
18. Mo J.Q., Dimashkieh H.H., Bove K.E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular mal- formation with associated capillary proliferation. Hum Pathol. 2004;35(2):200-209.
19. Pratt G.A. Birthmarks in infants. AMA Arch Derm Syphilol. 1953;67(3):302-305.
20. Yeh I., Bruckne A.L., Sanchez R., Jeng M.R., Newell B.D., Frieden I.J. Diffuse infantile hepatic hemangiomas: a report of four cases successfully managed with medical therapy. Pediatr Dermatol. 2011;28(3):267-275
