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Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017; 16: 73-80

Случай врожденной незрелой тератомы головы и шеи

Сагоян Г.Б. , Качанов Д.Ю. , Грачев Н.С. , Митрофанова А.М. , Моисеенко Р.А. , Ворожцов И.Н. , Терещенко Г.В. , Шаманская Т.В. , Варфоломеева С.Р.

https://doi.org/10.24287/1726-1708-2017-16-3-73-80

Аннотация

В работе описан клинический случай гигантской врожденной герминогенноклеточной опухоли (незрелая тератома, 2-я степень зрелости) мягких тканей головы и шеи с деструкцией большого крыла клиновидной кости, с распространением на полость рта с переходом за среднюю линию, инфильтрацией языка, полной обструкцией просвета носо- и ротоглотки у ребенка 15 дней жизни. Описаны особенности выполнения хирургического вмешательства с учетом распространенности опухолевого процесса. Обсуждаются вопросы классификации тератом, методы диагностики, представлены современные принципы терапии пациентов с данным заболеванием.
Список литературы

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Pediatric Hematology/Oncology and Immunopathology. 2017; 16: 73-80

Congenital immature teratoma of head and neck: case report

Sagoyan G. B., Kachanov D. Y., Grachev H. C., Mitrofanova A. M., Moiseenko R. A., Vorozhtcov I. N., Tereschenko G. V., Shamanskaya T. V., Varfolomeeva S. R.

https://doi.org/10.24287/1726-1708-2017-16-3-73-80

Abstract

The clinical case of a giant congenital germ cell tumor (immature teratoma, 2 grade) of soft tissues of the head and neck with destruction of the large wing of the sphenoid bone, with spreading to the oral cavity with the transition beyond the middle line, infiltration of the tongue, complete obstruction of the nasopharyngeal the child 15 days of life. The article describes Specific features of performing surgical intervention are described taking into account the prevalence of the tumor process. The discussed issues of teratoma classification, methods of diagnosis, provision of modern principles of therapy for patients with this disease.

References

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2. Schneider D.T., Calaminus G., et al. Epidemiologic Analysis of 1,442 Children and Adolescents Registered in the German Germ Cell Tumor Protocols. Pediatr Blood Cancer 2004; 42: 169-75.

3. Bernbeck B., Schneider D.T., Bern-beck B., et al. Germ Cell Tumors of the Head and Neck: Report from the MAKEI Study Group. Pediatr Blood Cancer 2009; 52: 223-6.

4. Harms D., Janig U. Germ cell tumours of childhood. Report of 170 cases including 59 pure and partial yolk-sac tumours. Virchows Arch a Pathol Anat Histopathol 1986; 409 (2): 223-39.

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7. Alexander V.R., Manjaly J.G., Pepper C.M., et al. Head and neck teratomas in children - A series of 23 cases at Great Ormond Street Hospital. Int J Pediatr Otorhinolaryngol 2015; 79 (12): 2008-14.

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11. Looijenga L.H., Oosterhuis J.W. Pathobiology of testicular germ cell tumors: views and news. Anal Quant Cytol Histol 2002; 24 (5): 263-79.

12. Holger M., Humphery P.A., Ulbright T.A., et al. WHO Classification of Tumours of the Urinary System and Male Genital Organs. International Agency for Research on Cancer, Lyon, 2016; 61.

13. Teilum G., Albrechtsen R., Norgaard-Pedersen B. The histogenetic-embryologic basis for reappearance of alpha-fetoprotein in endodermal sinus tumors (yolk sac tumors) and teratomas. Acta Pathol Microbiol Scand A 1975; 83 (1): 80-6.

14. Blohm M.E., Vesterling-Hörner D., Calaminus G., et al. Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol 1998; 15 (2): 135-42.

15. Trubnikova G.V., Stepanova T.V., Budanova M.V. i dr. Opukholi u novorozhdennykh detei. Detskaya onkologiya(dopolnenie): 5 s\"ezd detskikh onkologov Rossii. Tezisy 2012; 3: 73.

16. Meizner I. Perinatal oncology - the role of prenatal ultrasound diagnosis. Ultrasound Obstet Gynecol 2000; 16 (6): 507-9.

17. De Backer A., Madern G.C., van de Ven C.P., et al. Strategy for management of newborns with cervical teratoma. J Perinat Med 2004; 32 (6): 500-8.

18. Kerner B., Flaum E., Mathews H., et al. Cervical teratoma: prenatal diagnosis and long-term follow-up. Prenat Diagn 1998; 18 (1): 51-9.

19. Mann J.R., Gray E.S., Thornton C., et al. UK Children's Cancer Study Group Experience. Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience. J Clin Oncol 2008; 26 (21): 3590-7.

20. Marina N.M., Cushing B., Giller R., et al. Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study. J Clin Oncol 1999; 17 (7): 2137-43.

21. Göbel U., Calaminus G., Schneider D.T., et al. The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol. Klin Padiatr 2006; 218 (6): 309-14.