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Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2023; 22: 147-151

Сердечная недостаточность как проявление острого лимфобластного лейкоза

Андержанова Л. Х., Рыбалко Н. А., Шатский М. А., Тихомирова Е. А., Мякова Н. В.

https://doi.org/10.24287/1726-1708-2023-22-1-147-151

Аннотация

Клинически значимая инфильтрация миокарда бластными клетками при остром лейкозе встречается редко. Частота поражения сердца при онкогематологических заболеваниях у детей неизвестна. В данной статье представлено описание клинического случая пациентки 8 лет с В-клеточным острым лимфобластным лейкозом c сердечной недостаточностью, которая разрешилась на фоне специфической терапии злокачественного заболевания. Родители пациентки дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.

Список литературы

1. Hunkeler N., Canter C.E. Antemortem diagnosis of gross cardiac metastasis in childhood leukemia: echocardiographic demonstration. Pediatr cardiol 1990; 11 (4): 225–6.

2. Cheng H., Feldman T., Butt Y., Chow K.F., Yang X.Y., Bhattacharyya P.K., et al. T-cell prolymphocytic leukemia with extensive cardiovascular infiltrate leading to multiple myocardial infarctions and cardiac death. Tex Heart Inst J 2014; 41 (6): 626–30.

3. Sanchez-Correa B., Bergua J. M., Campos C., Gayoso I., Arcos M.J., Bañas H., et al. Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine 2013; 61(3): 885–91.

4. Tsimberidou A.M., Estey E., Wen S., Pierce S., Kantarjian H., Albitar M., et al. The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes. Cancer 2008; 113 (7): 1605–13.

5. Kalogeropoulos A.P., Georgiopoulou V.V., Butler J. From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin 2012; 8: 113–23.

6. Sumners J.E., Johnson W.W., Ainger L.E. Childhood leukemic heart disease. A study of 116 hearts of children dying of leukemia. Circulation 1969; 40 (4): 575–81.

7. Roberts W.C., Bodey G.P., Wertlake P.T. The heart in acute leukemia. A study of 420 autopsy cases. Am J Cardiol 1968; 21 (3): 388–412.

8. Klatt E.C., Heitz D.R. Cardiac metastases. Cancer 1990; 65 (6): 1456–9.

9. Prenner S.B., Franken A.A., Murphy I.G., Mikati I.A. Rapid Reversal of Focal Left Ventricular Hypertrophy and Systolic Dysfunction Resulting From Myocardial Infiltration by Acute Lymphoblastic Leukemia. Circulation 2016; 133 (7): 678–9.

10. De Lazzari M., Fedrigo M., Perazzolo Marra M., Calabrò F., Tarantini G., D'Amore E.G., et аl. Relapsing Leukemia Infiltrating the Heart. Circ Heart Fail 2015; 8 (6): 1133–4.

11. Barbaric D., Holley D., Lau K.C., McCowage G. It is ALL in the heart: a patient with acute lymphoblastic leukemia and cardiac infiltration at time of diagnosis. Leuk Lymphoma 2002; 43 (12): 2417–9.

12. Assuncao B.M.B.L., Handschumacher M.D., Brunner A.M., Yucel E., Bartko P.E., Cheng K.H., еt al. Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy. J Am Soc Echocardiogr 2017; 30 (11): 1111–8.

13. Mulrooney D.A., Yeazel M.W., Kawashima T., Mertens A.C., Mitby P., Stovall M., et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009; 339: b4606.

14. Jung M.H., Lee Y.H., Lee K.Y., Jung H.O., Youn H.J. Leukemic infiltration presenting as myocardial hypertrophy after complete remission of acute myeloid leukemia. Echocardiography 2017; 34 (1): 136–8.

Pediatric Hematology/Oncology and Immunopathology. 2023; 22: 147-151

Heart failure as a manifestation of acute lymphoblastic leukemia

Anderzhanova L. Kh., Rybalko N. A., Shatsky M. A., Tikhomirova E. A., Myakova N. V.

https://doi.org/10.24287/1726-1708-2023-22-1-147-151

Abstract

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate in children with hemato-oncological diseases is unknown. Here we report a clinical case of an 8-year-old female patient with B-cell acute lymphoblastic leukemia as well as heart failure that resolved during specific therapy for the cancer. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.

References

1. Hunkeler N., Canter C.E. Antemortem diagnosis of gross cardiac metastasis in childhood leukemia: echocardiographic demonstration. Pediatr cardiol 1990; 11 (4): 225–6.

2. Cheng H., Feldman T., Butt Y., Chow K.F., Yang X.Y., Bhattacharyya P.K., et al. T-cell prolymphocytic leukemia with extensive cardiovascular infiltrate leading to multiple myocardial infarctions and cardiac death. Tex Heart Inst J 2014; 41 (6): 626–30.

3. Sanchez-Correa B., Bergua J. M., Campos C., Gayoso I., Arcos M.J., Bañas H., et al. Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine 2013; 61(3): 885–91.

4. Tsimberidou A.M., Estey E., Wen S., Pierce S., Kantarjian H., Albitar M., et al. The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes. Cancer 2008; 113 (7): 1605–13.

5. Kalogeropoulos A.P., Georgiopoulou V.V., Butler J. From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin 2012; 8: 113–23.

6. Sumners J.E., Johnson W.W., Ainger L.E. Childhood leukemic heart disease. A study of 116 hearts of children dying of leukemia. Circulation 1969; 40 (4): 575–81.

7. Roberts W.C., Bodey G.P., Wertlake P.T. The heart in acute leukemia. A study of 420 autopsy cases. Am J Cardiol 1968; 21 (3): 388–412.

8. Klatt E.C., Heitz D.R. Cardiac metastases. Cancer 1990; 65 (6): 1456–9.

9. Prenner S.B., Franken A.A., Murphy I.G., Mikati I.A. Rapid Reversal of Focal Left Ventricular Hypertrophy and Systolic Dysfunction Resulting From Myocardial Infiltration by Acute Lymphoblastic Leukemia. Circulation 2016; 133 (7): 678–9.

10. De Lazzari M., Fedrigo M., Perazzolo Marra M., Calabrò F., Tarantini G., D'Amore E.G., et al. Relapsing Leukemia Infiltrating the Heart. Circ Heart Fail 2015; 8 (6): 1133–4.

11. Barbaric D., Holley D., Lau K.C., McCowage G. It is ALL in the heart: a patient with acute lymphoblastic leukemia and cardiac infiltration at time of diagnosis. Leuk Lymphoma 2002; 43 (12): 2417–9.

12. Assuncao B.M.B.L., Handschumacher M.D., Brunner A.M., Yucel E., Bartko P.E., Cheng K.H., et al. Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy. J Am Soc Echocardiogr 2017; 30 (11): 1111–8.

13. Mulrooney D.A., Yeazel M.W., Kawashima T., Mertens A.C., Mitby P., Stovall M., et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009; 339: b4606.

14. Jung M.H., Lee Y.H., Lee K.Y., Jung H.O., Youn H.J. Leukemic infiltration presenting as myocardial hypertrophy after complete remission of acute myeloid leukemia. Echocardiography 2017; 34 (1): 136–8.