Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2021; 20: 108-115
Клинические варианты стеноза пищевода на фоне течения инфекционного эзофагита у детей
https://doi.org/10.24287/1726-1708-2021-20-4-108-115Аннотация
Инфекционные поражения пищевода отмечаются, как правило, у иммунокомпрометированных пациентов. Инфекционный эзофагит может быть как одним из первых проявлений первичного иммунодефицитного состояния, так и осложнением на фоне иммуносупрессивной терапии у пациентов с гематологическими и онкологическими заболеваниями. Тяжелым осложнением инфекционных эзофагитов является формирование стенозов пищевода. Терапевтическая тактика ведения пациентов с данной патологией продолжает обсуждаться. Целью настоящей публикации является демонстрация собственного опыта ведения пациентов с инфекционными стенозами пищевода. Проанализированы этиология, особенности клинической и эндоскопической картины, а также эффективность медикаментозной терапии и эндоскопических методов лечения. Данное исследование одобрено независимым этическим комитетом и утверждено решением ученого совета НМИЦ ДГОИ им. Дмитрия Рогачева. Родители пациентов дали согласие на использование информации, в том числе фотографий детей, в научных исследованиях и публикациях.
Список литературы
1. Hoversten P., Kamboj A.K., Wu T.T., Katzka D.A. Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. Dig Dis Sci 2019; 64 (7): 1893–900.
2. Patel N.C., Caicedo R.A. Esophageal infections: an update. Curr Opin Pediatr 2015; 27 (5): 642–8.
3. Katzka D.A. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 2 Volume Set Medications, Trauma, and Infection. Tenth Edit. Elsevier Inc; 2020.
4. Ghiselli A., Bizzarri B., Ferrari D., Manzali E., Gaiani F., Fornaroli F., et al. Endoscopic dilation in pediatric esophageal strictures: a literature review. Acta Biomed 2018; 89 (8-S): 27–32. DOI: 10.23750/abm.v89i8-S.7862
5. Dall’Oglio L., Caldaro T., Foschia F., Faraci S., Federici di Abriola G., Rea F., et al. Endoscopic management of esophageal stenosis in children: New and traditional treatments. World J Gastrointest Endosc 2016; 8 (4): 212–9.
6. Hyun J.J., Chun H.J., Keum B., Seo Y.S., Kim Y.S., Jeen Y.T., et al. Candida esophagitis complicated by esophageal stricture. Endoscopy 2010; 42 (Suppl 2): E180–1.
7. Lee K.J., Choi S.J., Kim W.S., Park S.S., Moon J.S., Ko J.S. Esophageal Stricture Secondary to Candidiasis in a Child with Glycogen Storage Disease 1b. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (1): 71–5.
8. Sheth A., Boktor M., Diamond K., Lavu K., Sangster G. Complete esophageal obliteration secondary to cytomegalovirus in AIDS patient. Diseases Esophagus 2010; 23 (6): E32–4.
9. Wang H.W., Kuo C.J., Lin W.R., Hsu C.M., Ho Y.P., Lin C.J., et al. Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan. Medicine (Baltimore) 2016; 95 (14): e3187.
10. Thomson M., Tringali A., Dumonceau J.M., Tavares M., Tabbers M.M., Furlano R., et al. Paediatric Gastrointestinal Endoscopy: European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines. J Pediatr Gastroenterol Nutr 2017; 64 (1): 133–53.
Pediatric Hematology/Oncology and Immunopathology. 2021; 20: 108-115
Clinical variants of esophageal stenosis caused by infectious esophagitis in children
https://doi.org/10.24287/1726-1708-2021-20-4-108-115Abstract
Infectious esophagitis (IE) is commonly seen in immunocompromised patients. IE may be the first symptom of immunodeficiency state, also can be complication of immunosuppressive therapy in patients with hematological and oncological diseases. Severe complication of IE is esophageal stenosis. Patient management tactics continue to be discussed. A purpose of our publication is to demonstrate our experience in the management of patients with infectious esophageal stenosis. The etiology, features of the clinical and endoscopic picture, as well as the effectiveness of drug therapy and endoscopic methods of treatment have been analyzed. The study was approved by the Independent Ethics Committee and the Scientific Council of the D. Rogachev NMRCPHOI. In each case, parents gave their consent to the use of their child’s data, including photographs, for research purposes and in publications.
References
1. Hoversten P., Kamboj A.K., Wu T.T., Katzka D.A. Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. Dig Dis Sci 2019; 64 (7): 1893–900.
2. Patel N.C., Caicedo R.A. Esophageal infections: an update. Curr Opin Pediatr 2015; 27 (5): 642–8.
3. Katzka D.A. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 2 Volume Set Medications, Trauma, and Infection. Tenth Edit. Elsevier Inc; 2020.
4. Ghiselli A., Bizzarri B., Ferrari D., Manzali E., Gaiani F., Fornaroli F., et al. Endoscopic dilation in pediatric esophageal strictures: a literature review. Acta Biomed 2018; 89 (8-S): 27–32. DOI: 10.23750/abm.v89i8-S.7862
5. Dall’Oglio L., Caldaro T., Foschia F., Faraci S., Federici di Abriola G., Rea F., et al. Endoscopic management of esophageal stenosis in children: New and traditional treatments. World J Gastrointest Endosc 2016; 8 (4): 212–9.
6. Hyun J.J., Chun H.J., Keum B., Seo Y.S., Kim Y.S., Jeen Y.T., et al. Candida esophagitis complicated by esophageal stricture. Endoscopy 2010; 42 (Suppl 2): E180–1.
7. Lee K.J., Choi S.J., Kim W.S., Park S.S., Moon J.S., Ko J.S. Esophageal Stricture Secondary to Candidiasis in a Child with Glycogen Storage Disease 1b. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (1): 71–5.
8. Sheth A., Boktor M., Diamond K., Lavu K., Sangster G. Complete esophageal obliteration secondary to cytomegalovirus in AIDS patient. Diseases Esophagus 2010; 23 (6): E32–4.
9. Wang H.W., Kuo C.J., Lin W.R., Hsu C.M., Ho Y.P., Lin C.J., et al. Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan. Medicine (Baltimore) 2016; 95 (14): e3187.
10. Thomson M., Tringali A., Dumonceau J.M., Tavares M., Tabbers M.M., Furlano R., et al. Paediatric Gastrointestinal Endoscopy: European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines. J Pediatr Gastroenterol Nutr 2017; 64 (1): 133–53.
