Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017; 16: 45-49
Клинический случай химиолучевой терапии недифференцированной плеоморфной саркомы параменингеальной локализации у ребенка
https://doi.org/10.24287/1726-1708-2017-16-2-45-49Аннотация
Список литературы
1. Radzikowska J., Kukwa W., Kukwa A., Czarnecka A., Krzeski A. Rhabdom-yosarcoma of the head and neck in children. Contemp Oncol (Pozn) 2015; 19 (2): 98-107.
2. Chang R.C., Dave S.P., Robinson P.G. Undifferentiated pleomorphic sarcoma of the parotid gland: A rare pediatric case. Head Neck 2008; 30 (7): 970-3.
3. Clark D.W., Moore B.A., Patel S.R., Guadagnolo B.A., Roberts D.B., Sturgis E.M. Malignant fibrous histiocytoma of the head and neck region. Head Neck 2011; 33 (3): 303-8.
4. Alaggio R., Collini P., Randall R.L., Barnette P., Million L., Coffin C.M. Undifferen-tiated high-grade pleomorphic sarcomas in children: A clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 2010; 13 (3): 209-17.
5. Paulino A.C., Fowler B.Z. Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol 2005 Mar; 22 (2): 89-101.
6. Mohan R.P., Verma S., Siddhu V.K., Agarwal N. Malignant fibrous histiocytoma. BMJ Case Rep 2013 (31): 2013.
7. Rosenberg A.E. Malignant fibrous histiocytoma: Past, present, and future. Skeletal Radiol 2003; 32 (11): 613-8.
8. Fletcher C.D. The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification. Histopathology 2014; 64 (1): 2-11.
9. Ding G.X., Duggan D.M., Coffey C.W., Deeley M., Hallahan D.E., Cmelak A., Malcolm A. A study on adaptive IMRT treatment planning using kv cone-beam CT. Radiother Oncol 2007 Oct; 85 (1): 116-25.
10. Brouwer C.L., Steenbakkers R.J., Bourhis J., Budach W., Grau C., Grégoire V., et al. CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG oncology and TROG consensus guidelines. Radiother Oncol 2015 Oct; 117 (1): 83-90
Pediatric Hematology/Oncology and Immunopathology. 2017; 16: 45-49
Pediatric clinical case of parameningeal undifferentiated pleomorphic sarcoma treated with chemoradiotherapy
https://doi.org/10.24287/1726-1708-2017-16-2-45-49Abstract
Malignant fibrous histiocytoma (MFH) is a rare “NON-RMS-LIKE” pediatric tumor with highly malignant clinical behavior, high metastatic potential and overall 5-year survival around 65-70%. Soft tissue sarcoma diagnostic work-up and optimal combination of systemic therapy and local therapy approaches are one of the most challenging issues in modern pediatric oncology. To present a clinical case of parameningeal undifferentiated pleomorphic sarcoma in 7-year old child treated with adaptive conformal radiotherapy aimed at local tumor control. We describe a method of combined treatment of patient with parameningeal UPS consisting of the intensity-modulated radiotherapy (IMRT) in the form of volumetrically-modulated arc- therapy (VMAT) aimed at local tumor control. The radiotherapy course was completed at the planned total dose of 54 Gy. Acute skin and mucosal toxicity not more than Grade 2 (RTOG scale) was noted during the treatment. A good partial response was recorded after chemoradiotherapy course had been finished. Histological verification of UPS diagnosis is complicated as substantial amount of tumor tissue material is required for immunohistochemical and cytogenetical studies. An aggressive surgical approach is a method of choice for local control in parameningeal soft-tissue sarcomas. However the adaptive radiotherapy was the only possible treatment method of local tumor control with significant decrease of high doses to adjacent normal organs and tissues.
References
1. Radzikowska J., Kukwa W., Kukwa A., Czarnecka A., Krzeski A. Rhabdom-yosarcoma of the head and neck in children. Contemp Oncol (Pozn) 2015; 19 (2): 98-107.
2. Chang R.C., Dave S.P., Robinson P.G. Undifferentiated pleomorphic sarcoma of the parotid gland: A rare pediatric case. Head Neck 2008; 30 (7): 970-3.
3. Clark D.W., Moore B.A., Patel S.R., Guadagnolo B.A., Roberts D.B., Sturgis E.M. Malignant fibrous histiocytoma of the head and neck region. Head Neck 2011; 33 (3): 303-8.
4. Alaggio R., Collini P., Randall R.L., Barnette P., Million L., Coffin C.M. Undifferen-tiated high-grade pleomorphic sarcomas in children: A clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 2010; 13 (3): 209-17.
5. Paulino A.C., Fowler B.Z. Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol 2005 Mar; 22 (2): 89-101.
6. Mohan R.P., Verma S., Siddhu V.K., Agarwal N. Malignant fibrous histiocytoma. BMJ Case Rep 2013 (31): 2013.
7. Rosenberg A.E. Malignant fibrous histiocytoma: Past, present, and future. Skeletal Radiol 2003; 32 (11): 613-8.
8. Fletcher C.D. The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification. Histopathology 2014; 64 (1): 2-11.
9. Ding G.X., Duggan D.M., Coffey C.W., Deeley M., Hallahan D.E., Cmelak A., Malcolm A. A study on adaptive IMRT treatment planning using kv cone-beam CT. Radiother Oncol 2007 Oct; 85 (1): 116-25.
10. Brouwer C.L., Steenbakkers R.J., Bourhis J., Budach W., Grau C., Grégoire V., et al. CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG oncology and TROG consensus guidelines. Radiother Oncol 2015 Oct; 117 (1): 83-90
