Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2021; 20: 148-153
Два случая кистозного ангиоматоза. Редкие наблюдения и обзор литературы
https://doi.org/10.24287/1726-1708-2021-20-4-148-153Аннотация
Кистозный ангиоматоз – это редкое заболевание, характеризующееся диссеминированным многоочаговым гемангиоматозным и/или лимфангиозным кистозным поражением костей, а в ряде случаев и внутренних органов. В мире описано всего несколько десятков таких больных. В статье приводится описание 2 клинических наблюдений больных, госпитализированных в НМИЦ ДГОИ им. Дмитрия Рогачева с подозрением на гистиоцитоз из клеток Лангерганса. Родители пациентов дали согласие на использование информации, в том числе фотографий детей, в научных исследованиях и публикациях. У обоих пациентов при обследовании были выявлены множественные кисты костей черепа, позвоночника, тазовых костей и конечностей, а также селезенки. Биопсия костных кист черепа не выявила данных за гистиоцитоз и другие новообразования. В обоих случаях был выставлен диагноз: кистозный ангиоматоз. Это редкое заболевание, о котором следует помнить при дифференциальном диагнозе у пациентов с кистозными поражениями костей и внутренних органов.
Список литературы
1. Najm A., Soltner-Neel E., Le Goff B., Guillot P., Maugars Y., Berthelot J.-M. Cystic angiomatosis, a heterogeneous condition: Four new cases and a literature review. Medicine 2016; 95 (43): e5213. DOI: 10.1097/MD.0000000000005213
2. Kumar V., Meghal T., Sun Y.H., Huang Y. Systemic Cystic Angiomatosis Mimicking Metastatic Cancer: A Case Report and Review of the Literature. Case Rep Med 2017; 2017: 5032630. DOI: 10.1155/2017/5032630
3. Dos Anjos C.S., Borges R.M.C., Chaves A.C., Fuzita W.H., Silva C.A.M., de Oliveira U.G.L. Cystic angiomatosis, pleural effusion and multiple bone lesions mimicking a metastatic malignant neoplasia: a case report. J Med Case Rep 2019; 13 (1): 265. DOI: 10.1186/s13256- 019-2196-3
4. Jacobs J.E., Kimmelstiel P. Cystic angiomatosis of the skeletal system. J Bone Joint Surg Am 1953; 35-A (2): 409–20; passim.
5. Marcucci G., Masi L., Carossino A.M., Franchi A., Capanna R., Sinigaglia L., Brandi M.L. Cystic bone angiomatosis: a case report treated with aminobisphosphonates and review of the literature. Calcif Tissue Int 2013; 93 (5): 462–71. DOI: 10.1007/s00223- 013-9761-3
6. Bauschard M.J., Hatch J.L., Liogier-Weyback L.E.R., Vandergrift W.A., McRackan T.R. Intracranial Complications From Temporal Bone Cystic Angiomatosis. Otol Neurotol 2017; 38 (2): e1–2. DOI: 10.1097/MAO.0000000000001294
7. Shivaram G.M., Pai R.K., Ireland K.B., Stevens K.J. Temporal progression of skeletal cystic angiomatosis. Skeletal Radiol 2007; 36 (12): 1199–204. DOI: 10.1007/s00256-007-0378-3
8. Levey D.S., MacCormack L.M., Sartoris D.J., Haghighi P., Resnick D., Thorne R. Cystic angiomatosis: case report and review of the literature. Skeletal Radiol 1996; 25 (3): 287–93. DOI: 10.1007/s002560050082
9. Aumann W.K., Maxfield C.M., Heath J.L. Asymptomatic Skeletal Cystic Angiomatosis May Be Managed Conservatively With Close Observation. J Pediatric Hematol Oncol 2020; 43 (2): е276–9. DOI: 10.1097/MPH.0000000000001750
10. Reid A.B., Reid I.L., Johnson G., Hamonic M., Major P. Familial diffuse cystic angiomatosis of bone. Clin Orthop Relat Res 1989; (238): 211–8.
Pediatric Hematology/Oncology and Immunopathology. 2021; 20: 148-153
Two rare cases of cystic angiomatosis and a literature review
https://doi.org/10.24287/1726-1708-2021-20-4-148-153Abstract
Cystic angiomatosis is a rare disease characterized by disseminated multifocal hemangiomatous and/or lymphangiomatous cystic lesions of the skeleton with possible visceral organ involvement. Only a few dozens of such patients worldwide have been described in the literature. This article presents two case reports of the patients admitted to the D. Rogachev NRMCPHOI with suspected Langerhans cell histiocytosis. The patient’s parents gave their consent to the use of their child’s data, including photographs, for research purposes and in publications. During the investigation, multiple cysts of the skull bones, spine, pelvic bones and limbs, as well as of the spleen were found in both patients. A biopsy of the bone cysts of the skull revealed no data in favor of histiocytosis or other neoplasms. Cystic angiomatosis was diagnosed in both cases. This is a rare disease that should be kept in mind in the differential diagnosis in patients with cystic lesions of the bones and visceral organs.
References
1. Najm A., Soltner-Neel E., Le Goff B., Guillot P., Maugars Y., Berthelot J.-M. Cystic angiomatosis, a heterogeneous condition: Four new cases and a literature review. Medicine 2016; 95 (43): e5213. DOI: 10.1097/MD.0000000000005213
2. Kumar V., Meghal T., Sun Y.H., Huang Y. Systemic Cystic Angiomatosis Mimicking Metastatic Cancer: A Case Report and Review of the Literature. Case Rep Med 2017; 2017: 5032630. DOI: 10.1155/2017/5032630
3. Dos Anjos C.S., Borges R.M.C., Chaves A.C., Fuzita W.H., Silva C.A.M., de Oliveira U.G.L. Cystic angiomatosis, pleural effusion and multiple bone lesions mimicking a metastatic malignant neoplasia: a case report. J Med Case Rep 2019; 13 (1): 265. DOI: 10.1186/s13256- 019-2196-3
4. Jacobs J.E., Kimmelstiel P. Cystic angiomatosis of the skeletal system. J Bone Joint Surg Am 1953; 35-A (2): 409–20; passim.
5. Marcucci G., Masi L., Carossino A.M., Franchi A., Capanna R., Sinigaglia L., Brandi M.L. Cystic bone angiomatosis: a case report treated with aminobisphosphonates and review of the literature. Calcif Tissue Int 2013; 93 (5): 462–71. DOI: 10.1007/s00223- 013-9761-3
6. Bauschard M.J., Hatch J.L., Liogier-Weyback L.E.R., Vandergrift W.A., McRackan T.R. Intracranial Complications From Temporal Bone Cystic Angiomatosis. Otol Neurotol 2017; 38 (2): e1–2. DOI: 10.1097/MAO.0000000000001294
7. Shivaram G.M., Pai R.K., Ireland K.B., Stevens K.J. Temporal progression of skeletal cystic angiomatosis. Skeletal Radiol 2007; 36 (12): 1199–204. DOI: 10.1007/s00256-007-0378-3
8. Levey D.S., MacCormack L.M., Sartoris D.J., Haghighi P., Resnick D., Thorne R. Cystic angiomatosis: case report and review of the literature. Skeletal Radiol 1996; 25 (3): 287–93. DOI: 10.1007/s002560050082
9. Aumann W.K., Maxfield C.M., Heath J.L. Asymptomatic Skeletal Cystic Angiomatosis May Be Managed Conservatively With Close Observation. J Pediatric Hematol Oncol 2020; 43 (2): e276–9. DOI: 10.1097/MPH.0000000000001750
10. Reid A.B., Reid I.L., Johnson G., Hamonic M., Major P. Familial diffuse cystic angiomatosis of bone. Clin Orthop Relat Res 1989; (238): 211–8.
