Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2020; 19: 170-176
Лечение синдрома полиорганной недостаточности, вызванного грамотрицательным сепсисом, у пациента с нейтропенией после аллогенной трансплантации гемопоэтических стволовых клеток. Клинический случай
https://doi.org/10.24287/1726-1708-2020-19-2-170-176Аннотация
Пациенты с иммуносупрессией, индуцированной высокодозной химиотерапией, подвержены высокому риску инфекционных осложнений с развитием полиорганной недостаточности, что может существенно увеличить летальность. Приводится клинический случай синдрома полиорганной недостаточности, обусловленного септическим шоком грамотрицательной этиологии, у ребенка после выполненной аллогенной трансплантации гемопоэтических стволовых клеток. Описаны методы интенсивной терапии на отдельных этапах лечения, особенности мониторинга показателей жизнедеятельности. Родители дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.
Список литературы
1. Balit C.R., Horan R., Dorofaeff T., Frndova H., Doyle J., Cox P.N., et al. Pediatric Hematopoietic Stem Cell Transplant and Intensive Care: Have Things Changed? Pediatr Crit Care Med 2016; 17 (3): 109–16.
2. Turki A.T., Lamm W., Schmitt C., Bayraktar E., Alashkar F., Metzenmacher M., et al. Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients. Ann Hematol, 2019; 98 (2): 491–500.
3. Gorbach S., Bartlett J., Blacklow N. Infectious diseases in medicine and surgery. Philadelphia: W.B. Saunders; 1998:903–9.
4. Brunkhorst F.M., Clark A.L., Forycki Z.F., Anker S.D. Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: the potential importance of bacterial translocation. Int J Cardiol 1999; 72: 310.
5. Rodriguez-Villalobos H., Struelens M.J., Jones R. Frequency and resistance rates of Pseudomonas aeruginosa in Europe: update from SENTRY surveillance program 2000. Clin Microbiol Infect 2002; 8(1): 906.
6. Matics T.J, Sanchez-Pinto L.N. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 2017; 171 (10): e172352.
Pediatric Hematology/Oncology and Immunopathology. 2020; 19: 170-176
The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report
https://doi.org/10.24287/1726-1708-2020-19-2-170-176Abstract
Patients with high-dose chemotherapy-induced immunosuppression are at high risk for infectious complications with multiple organ dysfunction, which may lead to significantly higher mortality. We report a clinical case of multiple organ dysfunction syndrome caused by gram-negative septic shock in a child after allogeneic hematopoietic stem cell transplantation. We describe intensive care treatment modalities employed at different stages of therapy as well as the specifics of vital signs monitoring. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
References
1. Balit C.R., Horan R., Dorofaeff T., Frndova H., Doyle J., Cox P.N., et al. Pediatric Hematopoietic Stem Cell Transplant and Intensive Care: Have Things Changed? Pediatr Crit Care Med 2016; 17 (3): 109–16.
2. Turki A.T., Lamm W., Schmitt C., Bayraktar E., Alashkar F., Metzenmacher M., et al. Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients. Ann Hematol, 2019; 98 (2): 491–500.
3. Gorbach S., Bartlett J., Blacklow N. Infectious diseases in medicine and surgery. Philadelphia: W.B. Saunders; 1998:903–9.
4. Brunkhorst F.M., Clark A.L., Forycki Z.F., Anker S.D. Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: the potential importance of bacterial translocation. Int J Cardiol 1999; 72: 310.
5. Rodriguez-Villalobos H., Struelens M.J., Jones R. Frequency and resistance rates of Pseudomonas aeruginosa in Europe: update from SENTRY surveillance program 2000. Clin Microbiol Infect 2002; 8(1): 906.
6. Matics T.J, Sanchez-Pinto L.N. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 2017; 171 (10): e172352.
