Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017; 16: 13-20
Эффективность профилактики и лечения ранней анемии недоношенных у новорожденных детей, родившихся с экстремально низкой и очень низкой массой тела
https://doi.org/10.24287/1726-1708-2017-16-4-13-20Аннотация
Список литературы
1. World Health Organisation; World Health Statistics. 2015. http://www.who.int/gho/publications/world_health_statistics/en/
2. Володин Н.Н. Неонатология: национальное руководство. Краткое издание. - М.: ГЭОТАР-Медиа, 2013, с. 548-559.
3. Байбарина Е.Н., Дегтярев Д.Н. Избранные клинические рекомендации по неонататологии. - М.: ГЭОТАР-Медиа, 2016, с. 155-167.
4. Carroll P.D. Umbilical cord blood-an untapped resource: strategies to decrease early red blood cell transfusions and improve neonatal outcomes. Clin Perinatol 2015; 42 (3): 541-56.
5. Детская гематология. Клинические рекомендации / Под ред. А.Г. Румянцева, А.А. Масчана, Е.В. Жуковской). - М.: ГЭОТАР-Медиа, 2015, с. 182-192.
6. Олс Р., Едер М. Гематология, иммунология и инфекционные болезни / Под ред. А.Г. Румянцева (Пер. сангл.). - М.: Логосфера, 2013, с. 408.
7. Valieva O.A., Strandjord T.P., Mayock D.E., Juul S.E. Effects of transfusions in extremely low birth weight infants: a retrospective study. J Pediatr 2009; 155 (3): 331-7.
8. Canadian Paediatric Society. Red blood cell transfusions in newborn infants: Revised guidelines. 2015.
9. Keir A., Pal S., Trivella M., Lieberman L., Callum J., Shehata N., et al. Adverse effects of red blood cell transfusions in neonates: a systematic review and meta-analysis. Transfusion 2016; 56 (11): 2773-80.
10. Whyte R., Kirpalani H. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev 2011 (11).
11. Santos A.M., Guinsburg R., Almeida M.F., et al. Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units. Pediatr 2015; 15: 1-8.
12. Duan J., Kong X., Li Q., et al. Association between anemia and bronchopulmonary dysplasia in preterm infants. Sci Rep 2016; 6: 22717.
13. Hakeem H.A., Mohamed G.B., Othman M.F. Retinopathy of prematurity: A study of prevalence and risk factors. Middle East Afr J Ophthalmol 2012; 19 (3): 289-94.
14. Jobe A.H., Bancalari E. Bronchopulmonary dysplasia. Am J RespirCrit Care Med 2001; 163 (7): 1723-9.
15. Christensen R.D. Associations between "early" red blood cell transfusion and severe intraventricular hemorrhage, and between "late" red blood cell transfusion and necrotizing enterocolitis. Semin Perinatol 2012; 36 (4): 283-9.
16. Wang Y.C., Chan O.W., Chiang M.C., Yang P.H., Chu S.M., et al. Red Blood Cell Transfusion and Clinical Outcomes in Extremely Low Birth Weight Preterm Infants. Pediatr Neonatol 2017; 58 (3): 216-22.
17. Mohamed A., Shah P.S. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. Pediatrics 2012; 129 (3): 529-40.
18. Patel R.M., Knezevic A., Shenvi N., Hinkes M., Keene S., et al. Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA 2016; 315 (9): 889-97.
19. Derienzo C., Smith P.B., Tanaka D., et al. Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis. Early Hum Dev 2014; 90 (5): 237-40.
20. Klein H.G., Flegel W.A., Natanson C. Red blood cell transfusion: precision vs imprecision medicine. JAMA 2015; 314 (15): 1557-8.
21. Venkatesh V., Khan R., Curley A., Hopewell S., Doree C., et al. The safety and efficacy of red cell transfusions in neonates: a systematic review of randomized controlled trials. Br J Haematol 2012; 158: 370-85.
22. Martin R.J., Di Fiore J.M., Walsh M.C. Hypoxic Episodes in Bronchopulmonary Dysplasia. Clin Perinatol 2015; 42: 825-38.
23. Титков К.В. Оптимизация интенсивной терапии новорожденных детей с пороками развития в послеоперационном периоде путем трансфузии аутологичной эритроцитарной массы из пуповинной крови / Автореф. дисс. ... канд. мед. наук. - М., Первый Московский государственный медицинский университет им. И.М. Сеченова, 2016.
24. Bianchi M., Giannantonio C., Spartano S., et al. Allogeneic umbilical cord blood red cell concentrates: an innovative blood product for transfusion therapy of preterm infants. Neonatology 2015; 107 (2): 81-6.
25. Franz A.R., Maier R.F., Thome U.H., Rüdiger M., Kron M., et al. The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol. Neonatology 2012; 101 (4): 301-5.
26. Kirpalani H., Whyte R.K., Andersen C., et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized controlled trail of a restrictive (low) versus liberal (high) transfusion threshold for extreme low birth weight infants. J Pediatr 2006;149: 301-7.
27. Chen H.L., Tseng H.I., Lu C.C., Yang S.N., Fan H.C., et al. Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria. Pediatr Neonatol 2009; 50 (3): 110-6.
28. Nopoulos P.C., Conrad A.L., Bell E.F., Strauss R.G., Widness J.A., et al. Long-term Outcome of Brain Structure in Premature Infants: Effects of Liberal vs Restricted Red Blood Cell Transfusions. Arch PediatrAdolesc Med 2011; 165 (5): 443-50.
29. Ibrahim M., Ho S.K., Yeo C.L. Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: a systematic review and meta-analysis. J Paediatr Child Health 2014; 50 (2): 122-30.
30. Борисова И.П., Дмитриев А.В., Морщакова Е.Ф. Ранняя анемия недоношенных: профилактика и лечение. Вопросы гематологии, онкологии и иммунопатологии в педиатрии 2004; 3 (1): 27-31.
31. Новиков A.B., Морщакова Е.Ф., Дмитриев A.B. и др. Эритропоэтин в комплексном лечении и профилактике анемии у детей при критических состояниях неонатального периода. Вопросы практической педиатрии 2006; 1 (4): 43.
32. Пилипенко Ю.Н., Дмитриев A.B., Морщакова Е.Ф. Сравнительная эффективность применения различных доз рекомбинантного человеческого эритропоэтина в профилактике и лечении ранней анемии недоношенных. Российский медико-биологический вестник им. академика И.П. Павлова 2008; 4: 97-103.
33. Демихов В.Г., Дмитриев А.В., Шокер О.А., Демихова Е.В. Ранняя анемия недоношенных: оптимизация стратегии терапии. Российскийжурналдетскойгематологииионкологии 2015; 1: 81-87.
34. Crowley M., Kirpalani H. A rational approach to red blood cell transfusion in the neonatal ICU. Curr Opin Pediatr 2010; 22 (2): 151-7.
35. Ohlsson A., Aher S.M. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2014; 26: 4.
36. Chou H., Chou H., Chung M., Zhou X., Lin H. Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants. Pediatr and Neonatol 2017; 58 (1): 48-56.
37. Safarulla A. A Review of Benefits of Cord Milking over Delayed Cord Clamping in the preterm infant and future directions of research. The Journal of Maternal-Fetal & Neonatal Medicine 2017; 30: 1-11.
38. Chapman J., Marfurt S., Reid J. Effectiveness of Delayed Cord Clamping in Reducing Postdelivery Complications in Preterm Infants: A Systematic Review. J Perinat Neonatal Nurs 2016; 30 (4): 372-8.
Pediatric Hematology/Oncology and Immunopathology. 2017; 16: 13-20
Prevention and treatment of anemia of prematurity in extremely and very low birth weight infants
https://doi.org/10.24287/1726-1708-2017-16-4-13-20Abstract
Evaluation and treatment of anemia of prematurity in extremely and very low birth weight infants are presented in this article. Research has been set as a retrospective analysis of 105 infants with anemia of prematurity (in the period from January 2004 to December 2016). This study aimed to analyze the frequency, the volume of red blood cells (RBC) transfusions, the age of the first RBC transfusion and factors associated with RBC transfusions in extremely and very low birth weight preterm infants. A combination of delayed umbilical cord clamping ("milking") and therapy with erythropoietin decrease significantly the frequency of RBC transfusion. There was no significant reduction in the frequency of RBC transfusions in the group of children treated only with erythropoietin, without milking. RBC transfusions increase the risk of bronchopulmonary dysplasia, retinopathy and periventricular leukomalacia. Late therapy with erythropoietin (from 8 days of life) does not increase the risk of developing severe forms of retinopathy of prematurity.
References
1. World Health Organisation; World Health Statistics. 2015. http://www.who.int/gho/publications/world_health_statistics/en/
2. Volodin N.N. Neonatologiya: natsional'noe rukovodstvo. Kratkoe izdanie. - M.: GEOTAR-Media, 2013, s. 548-559.
3. Baibarina E.N., Degtyarev D.N. Izbrannye klinicheskie rekomendatsii po neonatatologii. - M.: GEOTAR-Media, 2016, s. 155-167.
4. Carroll P.D. Umbilical cord blood-an untapped resource: strategies to decrease early red blood cell transfusions and improve neonatal outcomes. Clin Perinatol 2015; 42 (3): 541-56.
5. Detskaya gematologiya. Klinicheskie rekomendatsii / Pod red. A.G. Rumyantseva, A.A. Maschana, E.V. Zhukovskoi). - M.: GEOTAR-Media, 2015, s. 182-192.
6. Ols R., Eder M. Gematologiya, immunologiya i infektsionnye bolezni / Pod red. A.G. Rumyantseva (Per. sangl.). - M.: Logosfera, 2013, s. 408.
7. Valieva O.A., Strandjord T.P., Mayock D.E., Juul S.E. Effects of transfusions in extremely low birth weight infants: a retrospective study. J Pediatr 2009; 155 (3): 331-7.
8. Canadian Paediatric Society. Red blood cell transfusions in newborn infants: Revised guidelines. 2015.
9. Keir A., Pal S., Trivella M., Lieberman L., Callum J., Shehata N., et al. Adverse effects of red blood cell transfusions in neonates: a systematic review and meta-analysis. Transfusion 2016; 56 (11): 2773-80.
10. Whyte R., Kirpalani H. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev 2011 (11).
11. Santos A.M., Guinsburg R., Almeida M.F., et al. Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units. Pediatr 2015; 15: 1-8.
12. Duan J., Kong X., Li Q., et al. Association between anemia and bronchopulmonary dysplasia in preterm infants. Sci Rep 2016; 6: 22717.
13. Hakeem H.A., Mohamed G.B., Othman M.F. Retinopathy of prematurity: A study of prevalence and risk factors. Middle East Afr J Ophthalmol 2012; 19 (3): 289-94.
14. Jobe A.H., Bancalari E. Bronchopulmonary dysplasia. Am J RespirCrit Care Med 2001; 163 (7): 1723-9.
15. Christensen R.D. Associations between "early" red blood cell transfusion and severe intraventricular hemorrhage, and between "late" red blood cell transfusion and necrotizing enterocolitis. Semin Perinatol 2012; 36 (4): 283-9.
16. Wang Y.C., Chan O.W., Chiang M.C., Yang P.H., Chu S.M., et al. Red Blood Cell Transfusion and Clinical Outcomes in Extremely Low Birth Weight Preterm Infants. Pediatr Neonatol 2017; 58 (3): 216-22.
17. Mohamed A., Shah P.S. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. Pediatrics 2012; 129 (3): 529-40.
18. Patel R.M., Knezevic A., Shenvi N., Hinkes M., Keene S., et al. Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA 2016; 315 (9): 889-97.
19. Derienzo C., Smith P.B., Tanaka D., et al. Feeding practices and other risk factors for developing transfusion-associated necrotizing enterocolitis. Early Hum Dev 2014; 90 (5): 237-40.
20. Klein H.G., Flegel W.A., Natanson C. Red blood cell transfusion: precision vs imprecision medicine. JAMA 2015; 314 (15): 1557-8.
21. Venkatesh V., Khan R., Curley A., Hopewell S., Doree C., et al. The safety and efficacy of red cell transfusions in neonates: a systematic review of randomized controlled trials. Br J Haematol 2012; 158: 370-85.
22. Martin R.J., Di Fiore J.M., Walsh M.C. Hypoxic Episodes in Bronchopulmonary Dysplasia. Clin Perinatol 2015; 42: 825-38.
23. Titkov K.V. Optimizatsiya intensivnoi terapii novorozhdennykh detei s porokami razvitiya v posleoperatsionnom periode putem transfuzii autologichnoi eritrotsitarnoi massy iz pupovinnoi krovi / Avtoref. diss. ... kand. med. nauk. - M., Pervyi Moskovskii gosudarstvennyi meditsinskii universitet im. I.M. Sechenova, 2016.
24. Bianchi M., Giannantonio C., Spartano S., et al. Allogeneic umbilical cord blood red cell concentrates: an innovative blood product for transfusion therapy of preterm infants. Neonatology 2015; 107 (2): 81-6.
25. Franz A.R., Maier R.F., Thome U.H., Rüdiger M., Kron M., et al. The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol. Neonatology 2012; 101 (4): 301-5.
26. Kirpalani H., Whyte R.K., Andersen C., et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized controlled trail of a restrictive (low) versus liberal (high) transfusion threshold for extreme low birth weight infants. J Pediatr 2006;149: 301-7.
27. Chen H.L., Tseng H.I., Lu C.C., Yang S.N., Fan H.C., et al. Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria. Pediatr Neonatol 2009; 50 (3): 110-6.
28. Nopoulos P.C., Conrad A.L., Bell E.F., Strauss R.G., Widness J.A., et al. Long-term Outcome of Brain Structure in Premature Infants: Effects of Liberal vs Restricted Red Blood Cell Transfusions. Arch PediatrAdolesc Med 2011; 165 (5): 443-50.
29. Ibrahim M., Ho S.K., Yeo C.L. Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: a systematic review and meta-analysis. J Paediatr Child Health 2014; 50 (2): 122-30.
30. Borisova I.P., Dmitriev A.V., Morshchakova E.F. Rannyaya anemiya nedonoshennykh: profilaktika i lechenie. Voprosy gematologii, onkologii i immunopatologii v pediatrii 2004; 3 (1): 27-31.
31. Novikov A.B., Morshchakova E.F., Dmitriev A.B. i dr. Eritropoetin v kompleksnom lechenii i profilaktike anemii u detei pri kriticheskikh sostoyaniyakh neonatal'nogo perioda. Voprosy prakticheskoi pediatrii 2006; 1 (4): 43.
32. Pilipenko Yu.N., Dmitriev A.B., Morshchakova E.F. Sravnitel'naya effektivnost' primeneniya razlichnykh doz rekombinantnogo chelovecheskogo eritropoetina v profilaktike i lechenii rannei anemii nedonoshennykh. Rossiiskii mediko-biologicheskii vestnik im. akademika I.P. Pavlova 2008; 4: 97-103.
33. Demikhov V.G., Dmitriev A.V., Shoker O.A., Demikhova E.V. Rannyaya anemiya nedonoshennykh: optimizatsiya strategii terapii. Rossiiskiizhurnaldetskoigematologiiionkologii 2015; 1: 81-87.
34. Crowley M., Kirpalani H. A rational approach to red blood cell transfusion in the neonatal ICU. Curr Opin Pediatr 2010; 22 (2): 151-7.
35. Ohlsson A., Aher S.M. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2014; 26: 4.
36. Chou H., Chou H., Chung M., Zhou X., Lin H. Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants. Pediatr and Neonatol 2017; 58 (1): 48-56.
37. Safarulla A. A Review of Benefits of Cord Milking over Delayed Cord Clamping in the preterm infant and future directions of research. The Journal of Maternal-Fetal & Neonatal Medicine 2017; 30: 1-11.
38. Chapman J., Marfurt S., Reid J. Effectiveness of Delayed Cord Clamping in Reducing Postdelivery Complications in Preterm Infants: A Systematic Review. J Perinat Neonatal Nurs 2016; 30 (4): 372-8.
