Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2019; 18: 114-119
Стероидная лекарственная катаракта у пациентов с гемобластозами
https://doi.org/10.24287/1726-1708-2019-18-2-114-119Аннотация
Современные технологии лечения детей с онкогематологическими заболеваниями позволили значительно повысить показатель выживаемости пациентов этой группы, актуализировав важность сохранения их качества жизни. Больше половины пациентов, получивших длительную стероидную и лучевую терапию, страдает катарактой, которая снижает остроту зрения. В обзоре приведен анализ литературы, описывающей закономерности развития катаракты у пациентов, получающих стероидную и лучевую терапию, результаты анатомо-физиологических и биохимических исследований хрусталика и изучения метаболических изменений внутриглазной жидкости, приводящих к развитию катаракты.
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40. Zigman S., Paxhia T., Marinetti G., Girsch S. Lipids of human lens fiber cell membranes. Curr Eye Res 1984; 3 (7): 887–96.
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Pediatric Hematology/Oncology and Immunopathology. 2019; 18: 114-119
Steroid cataract in patients with hemoblastosis
https://doi.org/10.24287/1726-1708-2019-18-2-114-119Abstract
Modern technologies of treatment of children with oncohaematological diseases allowed to noticebly increase the survival indexes in this group of patients, enhancing the value of maintenance of their life quality. More than half of those who received long-term steriod and radiation treatment develop cataract that causes decrease in vision. In this review we represent data concerning mechanisms of cataract formation in patients after steriod and radiation treatment, results of anatomical, physiological and biochemical studies of the lens as well as metabolic changes in aqueous humor leading to cataract formation.
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32. Belkacemi Y., Labopin M., Vernant J.P., Prentice H.G., Tichelli A., Schattenberg A., et al. Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission: a study of the European Group for Blood and Marrow Transplantation. Int J Radiat Oncol Biol Phys 1998; 41 (3): 659–68.
33. Belkacémi Y., Ozsahin M., Pène F., Rio B., Laporte J.P., Leblond V., et al. Cataractogenesis after total body irradiation. Int J Radiat Oncol Biol Phys 1996; 35 (1): 53–60.
34. Benyunes M.C., Sullivan K.M., Deeg H.J., Mori M., Meyer W., Fisher L., et al. Cataracts after bone marrow transplantation: long-term follow-up of adults treated with fractionated total body irradiation. Int J Radiat Oncol Biol Phys 1995; 32 (3): 661–70.
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36. Deeg H.J., Flournoy N., Sullivan K.M., Sheehan K., Buckner C.D., Sanders J.E., et al. Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. Int J Radiat Oncol Biol Phys 1984; 10 (7): 957–64.
37. Elliott A.J., Oakhill A., Goodman S. Cataracts in childhood leukaemia. Br J Ophthalmol 1985 Jun; 69 (6): 459–61.
38. Calissendorff B.M., Bolme P. Cataract development and outcome of surgery in bone marrow transplanted children. Br J Ophthalmol 1993; 77 (1): 36–8.
39. Horwitz M., Auquier P., Barlogis V., Contet A., Poiree M., Kanold J., et al. Incidence and risk factors for cataract after haematopoietic stem cell transplantation for childhood leukaemia: an LEA study. Br J Haematol 2015; 168: 518–25.
40. Zigman S., Paxhia T., Marinetti G., Girsch S. Lipids of human lens fiber cell membranes. Curr Eye Res 1984; 3 (7): 887–96.
41. Costagliola C., Iuliano G., Menzione M., Apponi-Battini G., Auricchio G. Effect of topical glucocorticoid administration on the protein and nonprotein sulfhydryl groups of the rabbit lens. Ophthalmic Res 1987; 19 (6): 351–6.
42. Uga S., Nishigori H., Ishikawa S. Morphological study on glucocorticoid-induced cataract in developing chick embryo. Graefes Arch Clin Exp Ophthalmol 1994; 232 (7): 415–20.
43. Kosano H., Nishigori H. Steroid-induced cataract: other than in the whole animal system, in the lens culture system, androgens, estrogens and progestins as well as glucocorticoids produce a loss of transparency of the lens. Dev Ophthalmol 2002; 35: 161–8.
44. Pescosolido N., Miccheli A., Manetti C., Iannetti G.D., Feher J., Cavallotti C. Metabolic changes in rabbit lens induced by treatment with dexamethasone. Ophthalmic Res 2001; 33 (2): 68–74.
45. Petersen A., Carlsson T., Karlsson J.O., Jonhede S., Zetterberg M. Effects of dexa-methasone on human lens epithelial cells in culture. Mol Vis 2008; 14: 1344–52.
46. Wang L., Liu D., Liu P., Yu Y. Proteomics analysis of water insoluble-urea soluble crystallins from normal and dexamethasone exposed lens. Mol Vis 2011; 17: 3423–36. Epub 2011 Dec 28.
47. Wang C., Dawes L.J. Liu Y., Wen L., Lovicu F.J., McAvoy J.W. Dexamethasone influences FGF-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract. Experimental Eye Research 2013; 111: 79–87.
48. Nakano-Ito K., Fujikawa Y., Hihara T., Shinjo H., Kotani S., Suganuma A., et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci 2014; 137 (1): 249–58.
