Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2019; 18: 81-87
Панникулитоподобная Т-клеточная лимфома у детей
https://doi.org/10.24287/1726-1708-2019-18-1-81-87Аннотация
Подкожная панникулитоподобная Т-клеточная лимфома - редкая форма периферической Т-клеточной лимфомы. Частота встречаемости данной патологии составляет 1% всех первичных Т-клеточных лимфом кожи; при этом 20% общего числа пациентов с этой патологией - дети и подростки, таким образом, процент встречаемости данного типа опухоли в детском возрасте - менее 1%. Учитывая редкость этого заболевания, не существует единой тактики терапии и оценки ее эффективности. В статье представлен обзор литературы, посвященный описанию, диагностике и лечению панникулитоподобной Т-клеточной лимфомы, рассмотрен клинический случай данного типа лимфомы с прогрессирующим течением у ребенка 3 лет, которому в дальнейшем проведена трансплантация гемопоэтических стволовых клеток от гаплосовместимого родственного донора.
Родители пациента дали согласие на использование информации о нем, в том числе фотографий, в научных исследованиях и публикациях.
Список литературы
1. Swerdlow S.H., Campo E., Pileri S.A., Stefano A. Pileri, Nancy Lee Harris, Harald Stein, Reiner Siebert et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 2016; 12 7(20): 2375-90. DOI: 10.1182/blood-2016-01-643569.
2. Al Mahmoud R., Weitzman S.M.B., Schechter T., Ngan B., Abdelhaleem M., Alexander S. Peripheral T-cell Lymphoma in Children and Adolescents: A Singleinstitution Experience. Pediatr Oncol Hematol 2012; 34 (8): 611-20.
3. Lai C., Dunleavy K. NK/T-cell lymphomas in children. Best practice & research Clinical haematology, 2013; 26(1): 33-41. Doi: 10.1016/j.beha.2013.04.004.
4. Mellgren K., Attarbaschi A., Abla O., Alexander S., Bomken S., Bubanska E., et al. Kontny Non-anaplastic peripheral T cell lymphoma in children and adolescents - an international review of 143 cases. Ann Hematol, 2016; 95 (8): 1295.
5. Gonzalez C.L., Medeiros L.J., Bra-ziel R.M., Jaffe E.S. T-cell lymphoma involving subcutaneous soft tissue. A clinicopathologic entity commonly associated with hemophagocytic syndrom. Am J Surg Pathol 1991; 15 (1): 17-27.
6. Go R.S., Wester S.M. Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma. Cancer 2004; 101: 1404-13. DOI: 10.1002/cncr.20502
7. Rudolph N., Klemke C., Ziemer M., Simon J.C., Treudler R. Hemophagocytic lymphohistiocytosis associated with subcutaneous panniculitis-like T-cell lymphoma. JDDG (Journal der Deutschen Dermatologischen Gesellschaft) 2016; 14: 1140-2. DOI :10.1111/ddg.12951
8. Hoque S., Child F., Whittaker S., Ferreira S., Orchard G., Jenner K., Spittle M., Russell-Jones R. Subcutaneous panniculitis-like T-cell lymphoma: a clin-icopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 2003; 148: 516-25. DOI: 10.1046/j.1365-2133.2003.05226.x
9. Rein Willemze. Cutaneous lymphomas with a panniculitic presentation. Seminars in Diagnostic Pathology 2017; 34 (1): 36-43.
10. Oschlies I., Simonitsch-Klupp I., Mal-dyk J., Konovalov D., Abramov D., Myakova N., et al. Subcutaneous panniculitis-like T-cell lymphoma in children: a detailed clinicopathological description of 11 multifocal cases with a high frequency of haemophagocytic syndrome. Br J Dermatol 2015; 172: 793-97. DOI: 10.1111/bjd.13440
11. Yi L., Qun S., Wenjie Z., Wen Z. The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous yS T-cell lymphoma may mimic those of rheumatic diseases: a report of 11 cases. Clinical Rheumatology 2013; 32 (8): 1169-75. DOI: 10.1007/s10067-013-22587
12. Notaro E., Shustov A., Chen X., Shino-hara M.M. Kikuchi-Fujimoto Disease Associated With Subcutaneous Panniculitis-Like T-cell Lymphoma. Am J Dermatopathol 2016; 38 (6): e77-e80. DOI: 10.1097/DAD.0000000000000486
13. Huppmann A.R., Xi L., Raffeld M., Pitta-luga S., Jaffe E.S. Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential. Pediatr Blood&Cancer 2013; 60: 1165-70. DOI: 10.1002/pbc.24462
14. Garcia-Herrera A., Calonje E. Cutaneous Lymphomas with Cytotoxic Phenotype Surgical Pathology Clinics 2017; 10 (2): 409-27.
15. Hu Z.L., Sang H., Deng L., Li Z. Subcutaneous Panniculitis-Like T-cell Lymphoma in Children: A Review of the Literature. Pediatr Dermatol, 2015; 32: 526-532. DOI: 10.1111/pde.12452
16. Brown N.A., Ross C.W., Gudjonsson J.E., Daniel Wale D., Attaphol Pawarode A., Maillard I., Hristov A.C. Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement. Am J Clinic Pathol 2015; 143 (2): 265-73. https://doi.21.org/10.1309/AJCPVZYB19NEDXXZ
17. Lozzi G.P., Massone C., Citarella L., Kerl H., Cerroni L. Rimming of Adipocytes By Neoplastic Lymphocytes: A Histopathologic Feature Not Restricted to Subcutaneous T-cell Lymphoma. Am J Dermatopathol, 2006; 28 (1): 9-12. 22. DOI: 10.1097/01.dad.0000187933.87103.03
18. Abramov D.S., Konovalov D.M., Rogoz-hin D.V., Myakova N.V., Biyachuev E.R., Roshchin V.Y., et al. Subcutaneous panniculitis-like T-cell lymphoma in children. Literature review and case reports. 23. Oncohematology 2013; 8 (2): 34-40. (In Russ.) https://doi.org/10.17650/1818-8346-2013-8-2-34-40
19. Maliniemi P., Hahtola S., Ovaska K., Jeskanen L., Vakeva L, Jantti K., et al. Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes. Orphanet Journal of Rare Diseases 2014; 9: 160. DOI: 10.1186/s13023-014-0160-2
20. Chen, C.-C., Teng, C.-L., & Yeh, S.-P. Relapsed and refractory subcutaneous panniculitis-like T-cell lymphoma with excellent response to cyclosporine: a case report and literature review. Annals of Hematology 2016; 95 (5): 837-40. DOI: 10.1007/s00277-016-2615-0
21. Zhang X., Schlaak M., Fabri M., Mauch C., Kurschat P. Successful Treatment of a Panniculitis-Like Primary Cutaneous T-cell Lymphoma of the а/p Type with Bexarotene. Case Reports in Dermatology 2012; 4 (1): 56-60. Doi:10.1159/000337433.
22. Dholaria B., Patel R.J., Sluzevich J.C., Ailawadhi S., Roy V. Relapsed subcutaneous panniculitis-like T cell lymphoma: role of haploidentical hematopoietic stem cell transplant. Ann Hematol 2017; 96: 2125-6. https://doi.org/10.1007/s00277-017-3119-2
23. Lin T.-A., Yang C.-F., Liu Y.-C., Liu J.-H., Chiou T., Hsiao L.-T., et al. Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. Int J Hematol 2018; 18 (12185): 2568-71. https://doi.org/10.1007/s12185-018-02568-9
Pediatric Hematology/Oncology and Immunopathology. 2019; 18: 81-87
Panniculitis-like T-cell lymphoma in children
https://doi.org/10.24287/1726-1708-2019-18-1-81-87Abstract
Subcutaneous panniculitis-like T-cell lymphoma is a rare form of peripheral T-cell lymphoma. The frequency of occurrence of this pathology is 1% of all primary T-cell lymphomas of the skin, at that 20% of all population are children and adolescents, in this way, the percentage of occurrence of this type of tumor in the pediatric population is less than 1%. Given the rarity of pathology, there is no single tactic of therapy and an assessment of its effectiveness. This article presents a review of the literature on the description, diagnosis, and treatment of panniculitis-like T-cell lymphoma. It also presents a clinical case of the development of this type of lymphoma in a 3-year-old child, with a progressive course and subsequent HScT from a haploinentical relative donor.
Patient's parents agreed to use personal dats and photos in research and publications.
References
1. Swerdlow S.H., Campo E., Pileri S.A., Stefano A. Pileri, Nancy Lee Harris, Harald Stein, Reiner Siebert et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 2016; 12 7(20): 2375-90. DOI: 10.1182/blood-2016-01-643569.
2. Al Mahmoud R., Weitzman S.M.B., Schechter T., Ngan B., Abdelhaleem M., Alexander S. Peripheral T-cell Lymphoma in Children and Adolescents: A Singleinstitution Experience. Pediatr Oncol Hematol 2012; 34 (8): 611-20.
3. Lai C., Dunleavy K. NK/T-cell lymphomas in children. Best practice & research Clinical haematology, 2013; 26(1): 33-41. Doi: 10.1016/j.beha.2013.04.004.
4. Mellgren K., Attarbaschi A., Abla O., Alexander S., Bomken S., Bubanska E., et al. Kontny Non-anaplastic peripheral T cell lymphoma in children and adolescents - an international review of 143 cases. Ann Hematol, 2016; 95 (8): 1295.
5. Gonzalez C.L., Medeiros L.J., Bra-ziel R.M., Jaffe E.S. T-cell lymphoma involving subcutaneous soft tissue. A clinicopathologic entity commonly associated with hemophagocytic syndrom. Am J Surg Pathol 1991; 15 (1): 17-27.
6. Go R.S., Wester S.M. Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma. Cancer 2004; 101: 1404-13. DOI: 10.1002/cncr.20502
7. Rudolph N., Klemke C., Ziemer M., Simon J.C., Treudler R. Hemophagocytic lymphohistiocytosis associated with subcutaneous panniculitis-like T-cell lymphoma. JDDG (Journal der Deutschen Dermatologischen Gesellschaft) 2016; 14: 1140-2. DOI :10.1111/ddg.12951
8. Hoque S., Child F., Whittaker S., Ferreira S., Orchard G., Jenner K., Spittle M., Russell-Jones R. Subcutaneous panniculitis-like T-cell lymphoma: a clin-icopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 2003; 148: 516-25. DOI: 10.1046/j.1365-2133.2003.05226.x
9. Rein Willemze. Cutaneous lymphomas with a panniculitic presentation. Seminars in Diagnostic Pathology 2017; 34 (1): 36-43.
10. Oschlies I., Simonitsch-Klupp I., Mal-dyk J., Konovalov D., Abramov D., Myakova N., et al. Subcutaneous panniculitis-like T-cell lymphoma in children: a detailed clinicopathological description of 11 multifocal cases with a high frequency of haemophagocytic syndrome. Br J Dermatol 2015; 172: 793-97. DOI: 10.1111/bjd.13440
11. Yi L., Qun S., Wenjie Z., Wen Z. The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous yS T-cell lymphoma may mimic those of rheumatic diseases: a report of 11 cases. Clinical Rheumatology 2013; 32 (8): 1169-75. DOI: 10.1007/s10067-013-22587
12. Notaro E., Shustov A., Chen X., Shino-hara M.M. Kikuchi-Fujimoto Disease Associated With Subcutaneous Panniculitis-Like T-cell Lymphoma. Am J Dermatopathol 2016; 38 (6): e77-e80. DOI: 10.1097/DAD.0000000000000486
13. Huppmann A.R., Xi L., Raffeld M., Pitta-luga S., Jaffe E.S. Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential. Pediatr Blood&Cancer 2013; 60: 1165-70. DOI: 10.1002/pbc.24462
14. Garcia-Herrera A., Calonje E. Cutaneous Lymphomas with Cytotoxic Phenotype Surgical Pathology Clinics 2017; 10 (2): 409-27.
15. Hu Z.L., Sang H., Deng L., Li Z. Subcutaneous Panniculitis-Like T-cell Lymphoma in Children: A Review of the Literature. Pediatr Dermatol, 2015; 32: 526-532. DOI: 10.1111/pde.12452
16. Brown N.A., Ross C.W., Gudjonsson J.E., Daniel Wale D., Attaphol Pawarode A., Maillard I., Hristov A.C. Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement. Am J Clinic Pathol 2015; 143 (2): 265-73. https://doi.21.org/10.1309/AJCPVZYB19NEDXXZ
17. Lozzi G.P., Massone C., Citarella L., Kerl H., Cerroni L. Rimming of Adipocytes By Neoplastic Lymphocytes: A Histopathologic Feature Not Restricted to Subcutaneous T-cell Lymphoma. Am J Dermatopathol, 2006; 28 (1): 9-12. 22. DOI: 10.1097/01.dad.0000187933.87103.03
18. Abramov D.S., Konovalov D.M., Rogoz-hin D.V., Myakova N.V., Biyachuev E.R., Roshchin V.Y., et al. Subcutaneous panniculitis-like T-cell lymphoma in children. Literature review and case reports. 23. Oncohematology 2013; 8 (2): 34-40. (In Russ.) https://doi.org/10.17650/1818-8346-2013-8-2-34-40
19. Maliniemi P., Hahtola S., Ovaska K., Jeskanen L., Vakeva L, Jantti K., et al. Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes. Orphanet Journal of Rare Diseases 2014; 9: 160. DOI: 10.1186/s13023-014-0160-2
20. Chen, C.-C., Teng, C.-L., & Yeh, S.-P. Relapsed and refractory subcutaneous panniculitis-like T-cell lymphoma with excellent response to cyclosporine: a case report and literature review. Annals of Hematology 2016; 95 (5): 837-40. DOI: 10.1007/s00277-016-2615-0
21. Zhang X., Schlaak M., Fabri M., Mauch C., Kurschat P. Successful Treatment of a Panniculitis-Like Primary Cutaneous T-cell Lymphoma of the a/p Type with Bexarotene. Case Reports in Dermatology 2012; 4 (1): 56-60. Doi:10.1159/000337433.
22. Dholaria B., Patel R.J., Sluzevich J.C., Ailawadhi S., Roy V. Relapsed subcutaneous panniculitis-like T cell lymphoma: role of haploidentical hematopoietic stem cell transplant. Ann Hematol 2017; 96: 2125-6. https://doi.org/10.1007/s00277-017-3119-2
23. Lin T.-A., Yang C.-F., Liu Y.-C., Liu J.-H., Chiou T., Hsiao L.-T., et al. Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. Int J Hematol 2018; 18 (12185): 2568-71. https://doi.org/10.1007/s12185-018-02568-9
