Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2018; 17: 111-119
Особенности морфологической диагностики и определение злокачественного потенциала адренокортикальных опухолей у детей
https://doi.org/10.24287/1726-1708-2018-17-3-111-119Аннотация
Опухоли коры надпочечников у детей встречаются редко. По клиническим проявлениям и биологическому поведению они отличаются от аналогичных опухолей у взрослых. В настоящем обзоре литературы представлено сравнение эпидемиологии, клиники, гистологического строения и биологического поведения опухолей коры надпочечников у взрослых и детей, особое внимание уделено подходам к определению злокачественности этих опухолей в разных возрастных группах.
Список литературы
1. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of endocrine organs. IARCPress, Lyon 2004: 139–42.
2. Stojadinovic A., Ghossein R.A., Hoss A., Nissan A., Marshall D., Dudas M., et al. Adrenocortical carcinoma: clinical, morphologic and molecular characterization. J Clin Oncol 2002; 20: 941–50. http://dx.doi.org/10.1200/JCO.20.4.941
3. Michalkiewicz E., Sandrini R., Figueiredo B.,Miranda E.C., Caran E., Oliveira-Filho A.G. Clinical outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. J Clin Oncol 2004; 22: 838–45. http://dx.doi.org/10.1200/JCO.2004.08.085
4. Faria A.M., Almeida M.Q. Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults. Molecular and Cellular Endocrinology 2012; 351: 52–7. http://dx.doi.org/10.1016/j.mce.2011.09.040
5. Stiller C.A. International variations in the incidence of Childhood Carcinoma. Cancer Epidemiology, Biomarkers and Prevention 1994; 3: 305–10.
6. Dehner L.P., Hill D.A. Adrenal Cortical Neoplasms in Children: Why So Many Carcinomas and Yet So Many Survivors? Pediatric and Developmental Pathology 2009; 12: 284–91. http://dx.doi.org/10.2350/08-06-0489.1
7. McWhirter W.R., Stiller C.A., Lennox E.L. Carcinomas in Childhood. A Regi-stry-Based Study of Incidence and Survival. Cancer 1989; 63: 2242–6. http://dx.doi.org/10.1002/1097-0142(19890601)63:11%3C2242:
8. AID-CNCR2820631131%3E3.0.CO;2-V
9. Sutter J.A., Grimberg A. Adrenocortical Tumors and Hyperplasias in Childhood - Etiology, Genetics, Clinical Presentation and Therapy. Pediatric Endocrinology Reviews 2006 Sep; 4 (1): 32–9.
10. Ribeiro R.C., Michalkevichz E.I., Figu-eiredo B.C., DeLacerda L., Sandrini F., Pianovsky M.D., et al. Adrenocortical tumors in children. Brazilian Journal of Medical and Biological Research 2000; 33: 1225–34. http://dx.doi.org/10.1590/S0100-879X2000001000013
11. Teinturier C., Pauchard M.S., Brugieres L., Landai P., Chaussain J.L., Bougnere P.F. Clinical and prognostic aspects of adrenocortical neoplasms in childhood. Medical and Pediatric Oncology 1999; 32: 106–11. http://dx.doi.org/10.1002/(SICI)1096-911X(199902)32:2%3C106::AID-MPO7%3E3.0.CO;2-J
12. Ciftci A.O., Senocak M.E., Tanyel C., Buyukpamukcu N. Adrenocortical tumors in children. Journal of Pediatric Surgery 2001; 36: 549–54. http://dx.doi.org/10.1053/jpsu.2001.22280
13. Al-Nafussi A. Tumor Diagnosis. Practical Approach and Pattern Analysis. London 2005: 4–62.
14. Sasano H., Suzuki T., Moriya T. Recent Advances in Histopathology and Immunohistochemistry of Adreno-cortical Carcinoma. Endocrine Pathology Winter 2006; 17 (4); 345–54.
15. http://dx.doi.org/10.1007/s12022-006-0006-0
16. Wieneke J.A., Thompson L.D.R., Heffess C.S. Adrenal cortical neoplasms in the pediatric population: A clinicopathologic and immunophenotype analysis of 83 patients. Am J Surg Pathol 2003; 27: 867–81. http://dx.doi.org/10.1097/00000478-200307000-00001
17. Paediatric Endocrine Tumours. A Multi-Disciplinary Consensus Statement of Best Practice from a Working Group Convened Under the Auspices of the BSPED and UKCCSG (rare tumour working groups). Edited by Helen A Spoudeas.
18. Wasserman J., Zambetti G., Malkin D. Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Molecular and Cellular Endocrinology 2012; 351: 101–10. http://dx.doi.org/10.1016/j.mce.2011.09.010
19. Doghman M. Wakil A., Cardinaud B., Thomas E., Wang J., Zhao W., et al. Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Research 2010; 70: 4666–75. http://dx.doi.org/10.1158/0008-5472.CAN-09-3970
20. Papotti M., Duregon E., Volante M., McNicol A. Pathology of the adrenal cortex: a reappraisal of the past 25 years focusing on adrenal cortical tumors. Endocrine Pathology 2014; 25: 35–48. http://dx.doi.org/10.1007/s12022-013-9291-6
21. Bezerra J., Latronic H.A. MicroRNA Era: the importance for diagnosis and prognosis of adrenocortical tumors. Biomed Research International 2014: 1–6. http://dx.doi.org/10.1155/2014/381917
22. de Reynies A., Assie G., Rickman D., Tissier F., Groussin L., Rene- Corail F., et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 2009; 27: 1108–15. http://dx.doi.org/10.1200/JCO.2008.18.5678
23. Wilkin F., Gagne ́ N., Paquette J., Oligny L., Deal C. Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. The Journal of Clinical Endocrinology and Metabolism 2000; 85: 2048–56. http://dx.doi.org/10.1210/jc.85.5.2048
24. Boechat G., Stinghen S., Custo ́dio G., Pianovski M., de Oliveira Figueiredo F., et al. Placental alkaline phosphatase in pediatric adrenocortical cancer. Journal of Pediatric Hematology and Oncology 2011; 33: 149–53. http://dx.doi.org/10.1097/MPH.0b013e3182099a80
25. Magro G., Esposito G., Cecchetto G., Dall’Igna P., Marcato R., Gambini C., et al. Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohistochemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (HLA) class II antigens: results from the Italian Pediatric Rare Tumor (TREP) Study project. Human Pathology 2012; 43: 31–9. http://dx.doi.org/10.1016/j.humpath.2011.04.016
Pediatric Hematology/Oncology and Immunopathology. 2018; 17: 111-119
Morphological diagnosis and assessment of the malignant potential in pediatric adrenal cortical neoplasms
https://doi.org/10.24287/1726-1708-2018-17-3-111-119Abstract
Adrenal cortical neoplasms in pediatric population are very rare. The clinical manifestations and biological behavior can be different from their counterparts in adults. This review contains data of epidemiology, clinical features, histology, biological behavior of adrenal cortical neoplasms in adults and children with particular attention to the approaches to malignancy assessment in different age groups.
References
1. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of endocrine organs. IARCPress, Lyon 2004: 139–42.
2. Stojadinovic A., Ghossein R.A., Hoss A., Nissan A., Marshall D., Dudas M., et al. Adrenocortical carcinoma: clinical, morphologic and molecular characterization. J Clin Oncol 2002; 20: 941–50. http://dx.doi.org/10.1200/JCO.20.4.941
3. Michalkiewicz E., Sandrini R., Figueiredo B.,Miranda E.C., Caran E., Oliveira-Filho A.G. Clinical outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. J Clin Oncol 2004; 22: 838–45. http://dx.doi.org/10.1200/JCO.2004.08.085
4. Faria A.M., Almeida M.Q. Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults. Molecular and Cellular Endocrinology 2012; 351: 52–7. http://dx.doi.org/10.1016/j.mce.2011.09.040
5. Stiller C.A. International variations in the incidence of Childhood Carcinoma. Cancer Epidemiology, Biomarkers and Prevention 1994; 3: 305–10.
6. Dehner L.P., Hill D.A. Adrenal Cortical Neoplasms in Children: Why So Many Carcinomas and Yet So Many Survivors? Pediatric and Developmental Pathology 2009; 12: 284–91. http://dx.doi.org/10.2350/08-06-0489.1
7. McWhirter W.R., Stiller C.A., Lennox E.L. Carcinomas in Childhood. A Regi-stry-Based Study of Incidence and Survival. Cancer 1989; 63: 2242–6. http://dx.doi.org/10.1002/1097-0142(19890601)63:11%3C2242:
8. AID-CNCR2820631131%3E3.0.CO;2-V
9. Sutter J.A., Grimberg A. Adrenocortical Tumors and Hyperplasias in Childhood - Etiology, Genetics, Clinical Presentation and Therapy. Pediatric Endocrinology Reviews 2006 Sep; 4 (1): 32–9.
10. Ribeiro R.C., Michalkevichz E.I., Figu-eiredo B.C., DeLacerda L., Sandrini F., Pianovsky M.D., et al. Adrenocortical tumors in children. Brazilian Journal of Medical and Biological Research 2000; 33: 1225–34. http://dx.doi.org/10.1590/S0100-879X2000001000013
11. Teinturier C., Pauchard M.S., Brugieres L., Landai P., Chaussain J.L., Bougnere P.F. Clinical and prognostic aspects of adrenocortical neoplasms in childhood. Medical and Pediatric Oncology 1999; 32: 106–11. http://dx.doi.org/10.1002/(SICI)1096-911X(199902)32:2%3C106::AID-MPO7%3E3.0.CO;2-J
12. Ciftci A.O., Senocak M.E., Tanyel C., Buyukpamukcu N. Adrenocortical tumors in children. Journal of Pediatric Surgery 2001; 36: 549–54. http://dx.doi.org/10.1053/jpsu.2001.22280
13. Al-Nafussi A. Tumor Diagnosis. Practical Approach and Pattern Analysis. London 2005: 4–62.
14. Sasano H., Suzuki T., Moriya T. Recent Advances in Histopathology and Immunohistochemistry of Adreno-cortical Carcinoma. Endocrine Pathology Winter 2006; 17 (4); 345–54.
15. http://dx.doi.org/10.1007/s12022-006-0006-0
16. Wieneke J.A., Thompson L.D.R., Heffess C.S. Adrenal cortical neoplasms in the pediatric population: A clinicopathologic and immunophenotype analysis of 83 patients. Am J Surg Pathol 2003; 27: 867–81. http://dx.doi.org/10.1097/00000478-200307000-00001
17. Paediatric Endocrine Tumours. A Multi-Disciplinary Consensus Statement of Best Practice from a Working Group Convened Under the Auspices of the BSPED and UKCCSG (rare tumour working groups). Edited by Helen A Spoudeas.
18. Wasserman J., Zambetti G., Malkin D. Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Molecular and Cellular Endocrinology 2012; 351: 101–10. http://dx.doi.org/10.1016/j.mce.2011.09.010
19. Doghman M. Wakil A., Cardinaud B., Thomas E., Wang J., Zhao W., et al. Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Research 2010; 70: 4666–75. http://dx.doi.org/10.1158/0008-5472.CAN-09-3970
20. Papotti M., Duregon E., Volante M., McNicol A. Pathology of the adrenal cortex: a reappraisal of the past 25 years focusing on adrenal cortical tumors. Endocrine Pathology 2014; 25: 35–48. http://dx.doi.org/10.1007/s12022-013-9291-6
21. Bezerra J., Latronic H.A. MicroRNA Era: the importance for diagnosis and prognosis of adrenocortical tumors. Biomed Research International 2014: 1–6. http://dx.doi.org/10.1155/2014/381917
22. de Reynies A., Assie G., Rickman D., Tissier F., Groussin L., Rene- Corail F., et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 2009; 27: 1108–15. http://dx.doi.org/10.1200/JCO.2008.18.5678
23. Wilkin F., Gagne ́ N., Paquette J., Oligny L., Deal C. Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. The Journal of Clinical Endocrinology and Metabolism 2000; 85: 2048–56. http://dx.doi.org/10.1210/jc.85.5.2048
24. Boechat G., Stinghen S., Custo ́dio G., Pianovski M., de Oliveira Figueiredo F., et al. Placental alkaline phosphatase in pediatric adrenocortical cancer. Journal of Pediatric Hematology and Oncology 2011; 33: 149–53. http://dx.doi.org/10.1097/MPH.0b013e3182099a80
25. Magro G., Esposito G., Cecchetto G., Dall’Igna P., Marcato R., Gambini C., et al. Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohistochemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (HLA) class II antigens: results from the Italian Pediatric Rare Tumor (TREP) Study project. Human Pathology 2012; 43: 31–9. http://dx.doi.org/10.1016/j.humpath.2011.04.016
