Тромбоз венозных синусов головного мозга и кровоизлияние в ткань головного мозга у пациента с лимфобластной лимфомой

Статья в Elpub

Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2015; 14: 43-47

Тромбоз венозных синусов головного мозга и кровоизлияние в ткань головного мозга у пациента с лимфобластной лимфомой

Евстратов Дмитрий Андреевич, Жарков Павел Александрович, Дьяконова Юлия Юрьевна, Абугова Юлия Георгиевна, Смирнова Надежда Владимировна, Фоминых Вероника Валерьевна, Мякова Наталья Валерьевна

https://doi.org/10.24287/1726-1708-2015-14-2-43-47

Аннотация

Пациенты с лимфобластными лимфомами успешно лечатся по протоколам, разработанным немецкой группой BFM (Berlin-Frankfurt-Münster). Редким осложнением терапии лимфобластных лимфом является тромбоз венозного синуса. Представлен клинический случай развития сочетанного тромбогеморрагического состояния у мальчика 12 лет с лимфобластной лимфомой. Ребенку проводили заместительную терапию фактором протромбинового комплекса, препаратом антитромбина III и антикоагулянтную терапию высокомолекулярным гепарином с переходом на низкомолекулярный гепарин. Через 5 мес антикоагулянтной терапии у ребенка зарегистрирована полная реканализация пораженных синусов.

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Pediatric Hematology/Oncology and Immunopathology. 2015; 14: 43-47

Cerebral venous sinus thrombosis and bleeding in the brain in a patient with lymphoblastic lymphoma

Evstratov D. A., Zharkov P. A., Dyakonova Yu. Yu., Abugova Yu. G., Smirnova N. V., Fominykh V. V., Myakova N. V.

https://doi.org/10.24287/1726-1708-2015-14-2-43-47

Abstract

Patients with lymphoblastic lymphomas are effectively treated according to protocols developed by the BFM (Berlin-Frankfurt-Münster) group. Venous sinus thrombosis is a rare complication of therapy for lymphoblastic lymphomas. A clinical case is presented: development of combined thrombohemorrhagic complication in a boy aged 12 years with lymphoblastic lymphoma. The patient received replacement therapy with prothrombin complex factor, antithrombin III, and anticoagulant therapy with high-molecular-weight heparin gradually replaced by low-molecular-weight heparin. Five months of anticoagulant therapy led to complete recanalization of the involved sinuses.

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8. Sutor AH, Mall V, Thomas KB. Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol. Klin Padiatr. 1999;211(4):201-4.

15. Ramsay NK, Coccia PF, Krivit W, Nesbit ME, Edson JR. The effect of L-asparaginase of plasma coagulation factors in acute lymphoblastic leukemia. Cancer. 1977;40(4):1398-401.

18. Bettigole RE, Himelstein ES, Oettgen HF, Clifford GO. Hypofibrinogenemia due to L-asparaginase: studies of fibrinogen survival using autologous 131-I-fibrinogen. Blood. 1970;35(2):195-200.

19. De Veber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, et al. Cerebral sinovenous thrombosis in children. N Engl J Med. 2001;345(6):417-23.

20. Grunt S, Wingeier K, Wehrli E, Boltshauser E, Capone A, Fluss J, et al. Cerebral sinus venous thrombosis in Swiss children. Dev Med Child Neurol. 2010; 52(12):1145-50.

22. Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES. Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States. J Child Neurol. 2008; 23(1):26-31.