Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017; 16: 62-68
Нутритивный статус и эффективность различных типов нутритивной поддержки у пациентов с неходжкинскими лимфомами в активной фазе лечения
https://doi.org/10.24287/1726-1708-2017-16-4-62-68Аннотация
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Pediatric Hematology/Oncology and Immunopathology. 2017; 16: 62-68
The nutritional status and efficiency of different types of nutritional support in patients with non-Hodgkin's lymphomas (NHL) in active phase of treatment
https://doi.org/10.24287/1726-1708-2017-16-4-62-68Abstract
The development of the tumor process and chemotherapy with its after-effects, can cause nutritional disorders that aggravate the course of the disease and complicate recovery of patient. It is very important to choose the right type of nutritional support (parenteral or enteral nutrition). The aim of the study was to determine changes in the nutritional status of children with non-Hodgkin's lymphomas (NHL), its effect on the duration of aplasia and development severe complications in the active treatment process and to assess the impact of different types of nutritional support on these parameters. The retrospective study with a comparative analysis was performed. It included 54 patients, including 40 (74%) boys, aged 1–17 years (median – 9 years). We analyzed anthropometric parameters – body mass index (BMI), triceps skinfold thickness (TSF), mid-upper arm muscle circumference (MUAMC) – on five periods of time respective to the course of therapy: "0" – 1–3 days before the beginning of cytoreductive phase of treatment; "1, 2, 3, 4" – the last day of the therapy and 4 days after it. The reliable positive dynamics of TSF during monitoring period was found (p < 0.05), it was more pronounced in patients with initial nutritional insufficiency (p < 0.05). It was associated with a greater incidence of severe complications (p = 0.02). Comparative analysis of types of nutritional support showed that the most effective is combination of enteral and parenteral nutrition, although the latest is associated with a greater frequency of nephro- and hepatotoxicity.
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