Андрология и генитальная хирургия. 2023; 24: 59-66
Место антиоксидантов в терапии мужского бесплодия
https://doi.org/10.17650/2070-9781-2023-24-4-59-66Аннотация
Проблема бесплодия затрагивает от 10 до 15 % пар во всем мире. На долю мужского фактора приходится до половины всех случаев бесплодия, при этом от 25 до 87 % случаев мужского бесплодия, как предполагают, обусловлены влиянием оксидативного стресса. Избыточная концентрация активных форм кислорода приводит к повреждению мембран сперматозоидов и нарушению целостности их ДНК, что отражается не только на вероятности наступления беременности естественным путем, но и на результатах применения вспомогательных репродуктивных технологий и риске невынашивания беременности. В данной работе представлен обзор экзогенных и эндогенных факторов антиоксидантной защиты, а также данные об их влиянии на параметры спермы и репродуктивное здоровье мужчин в целом.
Список литературы
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45. Comhaire F., Christophe A., Zalata A. et al. The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. Prostaglandins Leukot Essent Fatty Acids 2000;63(3):159–65. DOI: 10.1054/plef.2000.0174
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Andrology and Genital Surgery. 2023; 24: 59-66
The place of antioxidants in male infertility therapy
https://doi.org/10.17650/2070-9781-2023-24-4-59-66Abstract
Infertility affects 10 to 15 % of couples worldwide. Male factor accounts for up to half of infertility cases, with 25 to 87 % of male infertility cases thought to be caused by oxidative stress. Excessive concentrations of reactive oxygen species lead to damage to sperm membranes and disruption of the integrity of their DNA, which affects not only the likelihood of pregnancy naturally, but also the results of using assisted reproductive technologies and the risk of miscarriage. This paper provides an overview of exogenous and endogenous antioxidant protection factors, as well as their impact on sperm parameters and male reproductive health in general.
References
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25. Comhaire F. The role of food supplementation in the treatment of the infertile couple and for assisted reproduction. Andrologia 2010;42(5):331–40. DOI: 10.1111/j.1439-0272.2009.01025.x
26. Colagar A.N., Marzony E.T. Ascorbic acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr 2009;45(2):144–9. DOI: 10.3164/jcbn.08-251
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28. Lanzafame F.M., La Vignera S., Vicari E., Calogero A.E. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online 2009;19(5):638–59. DOI: 10.1016/j.rbmo.2009.09.014
29. Hambidge K.M., Krebs N.F. Zinc deficiency: a special challenge. J Nutr 2007;137(4):1101–5. DOI: 10.1093/jn/137.4.1101
30. Omu A.E., Al-Azemi M.K., Al-Maghrebi M. et al. Molecular basis for the effects of zinc deficiency on spermatogenesis: an experimental study in the Sprague-Dawley rat model. Indian J Urol 2015;31(1):57–64. DOI: 10.4103/0970-1591.139570
31. Giahi L., Mohammadmoradi S., Javidan A., Sadeghi M.R. Nutritional modifications in male infertility: a systematic review covering 2 decades. Nutr Rev 2016;74(2):118–30. DOI: 10.1093/nutrit/nuv059
32. Zhao J., Dong X., Hu X. et al. Zinc levels in seminal plasma and their correlation with male infertility: a systematic review and meta-analysis. Sci Rep 2016;6:22386. DOI: 10.1038/srep22386
33. Atig F., Raffa M., Ali H.B. et al. Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men. Int J Biol Sci 2012;8(1):139–49. DOI: 10.7150/ijbs.8.139
34. Flohé L. Selenium in mammalian spermiogenesis. Biol Chem 2007;388(10):987–95. DOI: 10.1515/BC.2007.112
35. Mossa M.M., Azzawi M.H., Dekhel H.H. et al. Effect of selenium in treatment of male infertility. Exp Tech Urol Nephrol 2018;1(5): ETUN.000521. DOI: 10.31031/ETUN.2018.01.000521
36. Ma L. , Sun Y. Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial. Randomized Controlled Trial. Eur Rev Med Pharmacol Sci 2022;26(13):4698–704. DOI: 10.26355/eurrev_202207_29194
37. Gvozdjáková A., Kucharská J., Dubravicky J. et al. Coenzyme Q10, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility. Dis Markers 2015;2015:827941. DOI: 10.1155/2015/827941
38. Safarinejad M.R. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol 2012;44(3):689–700. DOI: 10.1007/s11255-011-0081-0
39. Nadjarzadeh A., Shidfar F., Amirjannati N. et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia 2014;46(2):177–83. DOI: 10.1111/and.12062
40. Lafuente R., González-Comadrán M., Solà I. et al. Coenzyme Q10 and male infertility: a meta-analysis. J Assist Reprod Genet 2013;30(9):1147–56. DOI: 10.1007/s10815-013-0047-5
41. Ciftci H., Verit A., Savas M. et al. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology 2009;74(1):73–6. DOI: 10.1016/j.urology.2009.02.034
42. Lenzi A., Picardo M., Gandini L. et al. Glutathione treatment of dyspermia: effect on the lipoperoxidation process. Hum Reprod 1994;9(11):2044–50. DOI: 10.1093/oxfordjournals.humrep.a138391
43. Schisterman E.F., Sjaarda L.A., Clemons T. et al. Effect of folic acid and Zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: a randomized clinical trial. JAMA 2020;323(1):35–48. DOI: 10.1001/jama.2019.18714
44. Ozer Kaya S., Kandemir F.M., Gur S. et al. Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams. Andrologia 2020;52(1):e13439. DOI: 10.1111/and.13439
45. Comhaire F., Christophe A., Zalata A. et al. The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. Prostaglandins Leukot Essent Fatty Acids 2000;63(3):159–65. DOI: 10.1054/plef.2000.0174
46. Martínez-Soto J.C., Domingo J.C., Cordobilla B. et al. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Syst Biol Reprod Med 2016;62(6):387–95. DOI: 10.1080/19396368.2016.1246623
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