Андрология и генитальная хирургия. 2013; 14: 45-48
Влияние TGF-β1 и VEGF на процессы ангио- и нефрогенеза
https://doi.org/10.17650/2070-9781-2013-4-45-48Аннотация
На светооптическом и иммуногистохимическом уровнях изучены биоптаты почек детей с врожденным гидронефрозом в возрасте от 3 дней до 12 лет, полученные при нефрэктомии, с целью установления влияния факторов роста на процессы васкуляризации почки и созревания почечной ткани. Показано, что слабая экспрессия VEGF при более выраженной экспрессии TGF-β1 и его рецепторов – R1 и R2 – на различных структурах нефункционирующих или гипопластических почек у детей раннего возраста может быть критерием нарушенного ангио- и нефрогенеза.
Список литературы
1. Bertolino P., Deckers M., Lebrin F., Ten Dijke P. Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest 2005;128(6 Suppl):585S–90S.
2. Carev D., Saraga M., Saraga-Babic M. Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol 2008;23(7):853–62.
3. Lebrin F., Deckers M., Bertolino P., Ten Dijke P. TGF-beta receptor function in the endothelium. Cardiovasc Res 2005;65(3):599–608.
4. Ferrari G., Cook B.D., Terushkin V. et al. Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol 2009;219(2):449–58.
5. Gomez R.A., Norwood V.F., TufroMcReddie A. Development of the kidney vasculature. Microsc Res Tech 1997;39(3):254–60.
6. Kim B.S., Goligorsky M.S. Role of VEGF in kidney development, microvascular maintenance and
7. pathophysiology of renal disease. Korean J Intern Med 2003;18(2):65–75.
8. Sequeira Lopez M.L., Gomez R.A. Development of the renal arterioles. J Am Soc Nephrol 2011;22(12):2156–65.
9. Tufro A., Norwood V.F., Carey R.M., Gomez R.A. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol 1999;10(10):2125–34.
10. Zhoy Y., Takahashi G., Shinagava T. et al. Increased transforming growth factor-beta1 and tubulointerstitial fibrosis in rats with congenital hydronephrosis. Int J Urol 2002;9(9):491–500.
Andrology and Genital Surgery. 2013; 14: 45-48
TGF-β1 and VEGF influence on angio- and nephrogenesis processes
https://doi.org/10.17650/2070-9781-2013-4-45-48Abstract
Kidney biopsies obtained from 3 days – 12 years children with congenital hydronephrosis during nephrectomy operation were investigated under the light microscopy in our study. Also we did immunohistochemical reactions. The aim of our study was to reveal the growth factor influence on maturation and vascularisation of kidney parenchyma. We showed, that the low VEGF expression in association with higher expression of TGF-β1 and its receptors – R1 and R2 – on different structures of nonfunctioning or hypoplastic kidneys in children might be a criterion of abnormal angio- and nephrogenesis.
References
1. Bertolino P., Deckers M., Lebrin F., Ten Dijke P. Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest 2005;128(6 Suppl):585S–90S.
2. Carev D., Saraga M., Saraga-Babic M. Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol 2008;23(7):853–62.
3. Lebrin F., Deckers M., Bertolino P., Ten Dijke P. TGF-beta receptor function in the endothelium. Cardiovasc Res 2005;65(3):599–608.
4. Ferrari G., Cook B.D., Terushkin V. et al. Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol 2009;219(2):449–58.
5. Gomez R.A., Norwood V.F., TufroMcReddie A. Development of the kidney vasculature. Microsc Res Tech 1997;39(3):254–60.
6. Kim B.S., Goligorsky M.S. Role of VEGF in kidney development, microvascular maintenance and
7. pathophysiology of renal disease. Korean J Intern Med 2003;18(2):65–75.
8. Sequeira Lopez M.L., Gomez R.A. Development of the renal arterioles. J Am Soc Nephrol 2011;22(12):2156–65.
9. Tufro A., Norwood V.F., Carey R.M., Gomez R.A. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol 1999;10(10):2125–34.
10. Zhoy Y., Takahashi G., Shinagava T. et al. Increased transforming growth factor-beta1 and tubulointerstitial fibrosis in rats with congenital hydronephrosis. Int J Urol 2002;9(9):491–500.
