Андрология и генитальная хирургия. 2023; 24: 19-30
Негативное влияние фталатов на мужскую репродуктивную систему и фертильность
https://doi.org/10.17650/2070-9781-2023-24-2-19-30Аннотация
В обзоре представлены данные литературы о негативном влиянии фталатов на мужскую репродуктивную систему, сперматогенез, параметры эякулята и мужскую фертильность. При анализе научных публикаций найдено небольшое число исследований, посвященных изучению влияния фталатов на репродуктивное здоровье, гаметогенез и его гормональную регуляцию у человека и лабораторных моделей (крысы, мыши). Хотя эпидемиологические исследования о влиянии фталатов на репродуктивную функцию и фертильность мужчин немногочисленны, отдельные токсикологические исследования показывают, что некоторые фталаты являются потенциальными репротоксикантами.
Список литературы
1. Курило Л.Ф., Хилькевич Л.В. Современные подходы к изучению гонадо- и гаметотоксического эффекта экзогенных факторов. Медицинская генетика, экспресс-информация 1989;9:1–16.
2. RTECS(R) National Institute for Occupational Safety and Health. Canadian Centre for Occupational Health Safety, 2005.
3. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int J Hyg Environ Health 2007;210(5):623–34. DOI: 10.1016/j.ijheh.2007.07.011
4. Koo J.W., Parham F., Kohn M.C. et al. The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ Health Perspect 2002;110(4):405–10. DOI: 10.1289/ehp.02110405
5. Fasano E., Bono-Blay F., Cirillo T. et al. Migration of phthalates, alkylphenols, bisphenol A and di(2-ethylhexyl)adipate from food packaging. Food Control 2012;27(1):132–8. DOI: 10.1016/j.foodcont.2012.03.005
6. Reproductive and developmental toxicology. Ed. by R.C. Gupta. 2nd edn. Academic Press, Elsevier Inc., 2017. 1446 p.
7. Johns L.E., Cooper G.S., Galizia A., Meeker J.D. Exposure assessment issues in epidemiology studies of phthalates. Environ Int 2015;85:27–39. DOI: 10.1016/j.envint.2015.08.005
8. Talsness C.E., Andrade A.J., Kuriyama S.N. et al. Components of plastic: experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B Biol Sci 2009;364(1526): 2079–96. DOI: 10.1098/rstb.2008.0281
9. Шефтель В.О., Дышиневич Н.Е., Сова Р.Е. Токсикология полимерных материалов. Киев: Здоров’я, 1988. 210 с.
10. Chen X., Xu S., Tan T. et al. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. Int J Environ Res Publ Health 2014;11(3):3156–68.
11. Knez J. Endocrine-disrupting chemicals and male reproductive health. Reprod Biomed Online 2013;26(5):440–8. DOI: 10.1016/j.rbmo.2013.02.005
12. Calafat A.M., Ye X., Silva M.J et al. Human exposure assessment to environmental chemicals using biomonitoring. Int J Androl 2006;29(1):166–71; discussion 181–5. DOI: 10.1111/j.1365-2605.2005.00570.x
13. Rusyn I., Peters J.M, Cunningham ML, Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol 2006;36(5):459–79. DOI: 10.1080/10408440600779065
14. Heindel J.J., Powell C.J. Phthalate ester effects on rat Sertoli cell function in vitro: effects of phthalate side chain and age of animal. Toxicol Appl Pharmacol 1992;115(1):116–23. DOI: 10.1016/0041-008x(92)90374-2
15. Koch H.M., Bolt H.M., Preuss R. et al. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch Toxicol 2005;79(7):367–76. DOI: 10.1007/s00204-004-0642-4
16. Silva M.J., Barr D.B., Reidy J.A. et al. Glucuronidation patterns of common urinary and serum monoester phthalate metabolites. Arch Toxicol 2003;77(10):561–7. DOI: 10.1007/s00204-003-0486-3
17. Frederiksen H., Skakkebaek N.E., Andersson A.M. Metabolism of phthalates in humans. Mol Nutr Food Res 2007;51(7):899–911. DOI: 10.1002/mnfr.200600243
18. Шефтель В.О., Зинченко Т.М., Катаева С.Е. Санитарная токсикология фталатов, загрязнителей воды. Гигиена и санитария 1981;8:66–7.
19. Abdel daiem M.M., Rivera-Utrilla J., Ocampo-Pérez R. et al. Environmental impact of phthalic acid esters and their removal from water and sediments by different technologies – a review. J Environ Manage 2012;109:164–78. DOI: 10.1016/j.jenvman.2012.05.014
20. Lawrence W.H. Phthalate esters: the question of safety. Clin Toxicol 1978;13(1):89–139. DOI: 10.3109/15563657808988230
21. Энциклопедия по безопасности и гигиене труда. Пер. с англ., в 4 т. Международная организация труда. Под ред. А.П. Починок. 4-е изд. М.: М-во труда и соц. развития, 2001.
22. Wang Y.X., Liu C., Chen Y.J. et al. Predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men. Environ Res 2018;161:336–44. DOI: 10.1016/j.envres.2017.11.027
23. Duty S.M., Ackerman R.M., Calafat A.M., Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect 2005;113(11):1530–5. DOI: 10.1289/ehp.8083
24. Hauser R., Skakkebaek N.E., Hass U. et al. Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 2015;100(4):1267–77. DOI: 10.1210/jc.2014-4325
25. Fisher J.S., Macpherson S., Marchetti N., Sharpe R.M. Human ‛testicular dysgenesis syndrome’: a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003;18(7):1383–1394. DOI: 10.1093/humrep/deg273
26. Desdoits-Lethimonier C., Albert O., Le Bizec B. et al. Human testis steroidogenesis is inhibited by phthalates. Hum Reprod 2012;27(5):1451–9. DOI: 10.1093/humrep/des069
27. Skinner M.K., Anway M.D. Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors. Ann N Y Acad Sci 2005;1061;18–32. DOI: 10.1196/annals.1336.004
28. Kay V.R., Bloom M.S., Foster W.G. Reproductive and developmental effects of phthalate diesters in males. Crit Rev Toxicol 2014;44(6):467–98. DOI: 10.3109/10408444.2013.875983
29. Gray L.E. Jr., Ostby J., Furr J. et al. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000;58(2):350–65. DOI: 10.1093/toxsci/58.2.350
30. Chiba K., Kondo Y., Yamaguchi K. et al. Inhibition of claudin-11 and occludin expression in rat Sertoli cells by mono-(2-ethylhexyl) phthalate through p44/42 mitogen-activated protein kinase pathway. J Androl 2012;33(3):368–74. DOI: 10.2164/jandrol.111.013664
31. Harris C.A., Henttu P., Parker M.G., Sumpter J.P. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 1997;105(8):802–11. DOI: 10.1289/ehp.97105802
32. Foster P.M. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 2006;29(1):140–7; discussion 181–5. DOI: 10.1111/j.1365-2605.2005.00563.x
33. Dalgaard M., Nellemann C., Lam H.R. et al. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats. Toxicol Lett 2001;122(1):69–79. DOI: 10.1016/s0378-4274(01)00348-4
34. Zhang X.F., Zhang T., Wang L. et al. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep 2013;40(11):6509–17. DOI: 10.1007/s11033-013-2769-y
35. Akingbemi B.T., Youker R.T., Sottas C.M. et al. Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biol Reprod 2001;65(4):1252–9. DOI: 10.1095/biolreprod65.4.1252
36. Wang Y.X., Zeng Q., Sun Y. et al. Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: a cross-sectional study in China. Environ Pollut 2016;211:173–82. DOI: 10.1016/j.envpol.2015.12.052
37. Li X., Fang E.F., Scheibye-Knudsen M. et al. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis. Sci Rep 2014;4:6434. DOI: 10.1038/srep06434
38. Hauser R., Meeker J.D., Singh N.P. et al. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum Reprod 2007;22(3):688–95. DOI: 10.1093/humrep/del428
39. Liu L., Bao H., Liu F. et al. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environ Int 2012;42:78–83. DOI: 10.1016/j.envint.2011.04.005
40. Jurewicz J., Radwan M., Sobala W. et al. Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Reprod Toxicol 2013;42:232–41. DOI: 10.1016/j.reprotox.2013.10.001
41. Jönsson B.A., Richthoff J., Rylander L. et al. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 2005;16(4):487–93. DOI: 10.1097/01.ede.0000164555.19041.01
42. Joensen U.N., Frederiksen H., Blomberg Jensen M. et al. Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. Environ Health Perspect 2012;120(10):1397–403. DOI: 10.1289/ehp.1205113
43. Pant N., Shukla M., Kumar Patel D. et al. Correlation of phthalate exposures with semen quality. Toxicol Appl Pharmacol 2008;231(1):112–6. DOI: 10.1016/j.taap.2008.04.001
44. Wang Y.X., Zeng Q., Sun Y. et al. Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China. Environ Res 2016;150:557–65. DOI: 10.1016/j.envres.2015.11.023
45. Duty S.M., Singh N.P., Silva M.J. et al. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 2003;111(9):1164–9. DOI: 10.1289/ehp.5756
46. Carbone S., Szwarcfarb B., Ponzo O. et al. Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male rats. Neurotoxicology 2010;31(6):747–51. DOI: 10.1016/j.neuro.2010.06.006
47. State of the science of endocrine disrupting chemicals, 2012. Ed. by A. Bergman, J.J. Heindel, S. Jobling et al. UNEP& WHO, Geneva, Switzerland, 2013. 289 p. Available at: https://apps.who.int/iris/handle/10665/78101
48. Gore A.C., Chappell V.A., Fenton S.E. et al. EDC-2: the Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 2015;36(6):E1–E150. DOI: 10.1210/er.2015-1010
49. Levin E.R. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19(8):1951–9. DOI: 10.1210/me.2004-0390
50. Watson S., Alyea R.A., Jeng Y.J., Kochukov M.Y. Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues. Mol Cell Endocrinol 2007;274(1–2):1–7. DOI: 10.1016/j.mce.2007.05.011
51. Silva E., Kabil A., Kortenkamp A. Cross-talk between non-genomic and genomic signaling pathways – distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol 2010;245(2):160–70. DOI: 10.1016/j.taap.2010.02.015
52. Nadal A., Díaz M., Valverde M.A. The estrogen trinity: membrane, cytosolic, and nuclear effects. News Physiol Sci 2001;16:251–5. DOI: 10.1152/physiologyonline.2001.16.6.251
53. Takayanagi S., Tokunaga T., Liu X. et al. Endocrine disruptor bisphenol A strongly binds to human estrogen-related gamma receptor (ERRgamma) with high constitutive activity. Toxicol Lett 2006;167(2):95–105. DOI: 10.1016/j.toxlet.2006.08.012
54. Ho T.S.M., Tang W.Y., Belmonte de Frausto J., Prins G.S. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 2006;66(11):5624–32. DOI: 10.1158/0008-5472.CAN-06-0516
55. Whitehead S., Rice S. Endocrine-disrupting chemicals as modulators of sex steroid synthesis. Best Pract Res Clin Endocrinol Metab 2006;20(1):45–61. DOI: 10.1016/j.beem.2005.09.003
56. Lovekamp-Swan T., Jetten A.M., Davis B.J. Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Mol Cell Endocrinol 2003;201(1–2): 133–41. DOI: 10.1016/s0303-7207(02)00423-9
57. Gunnarsson D., Leffler P., Ekwurtzel E. et al. Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes. Reproduction 2008;135(5):693–703. DOI: 10.1530/REP-07-0460
58. Zhao Y., Ao H., Chen L. et al. Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation. Toxicol In Vitro 2012;26(6):950–5. DOI: 10.1016/j.tiv.2012.04.003
59. Barlow N.J., Phillips S.L., Wallace D.G. et al. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci 2003;73(2):431–41. DOI: 10.1093/toxsci/kfg087
60. Li L.H., Jester W.F. Jr., Laslett A.L., Orth J.M. A single dose of Di- (2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol 2000;166(3):222–9. DOI: 10.1006/taap.2000.8972
61. Tay T.W., Andriana B.B., Ishii M. et al. Disappearance of vimentin in Sertoli cells: a mono(2-ethylhexyl) phthalate effect. Int J Toxicol 2007;26(4):289–95. DOI: 10.1080/00207450701470757
62. Bloom M.S., Whitcomb B.W., Chen Z. et al. Associations between urinary phthalate concentrations and semen quality parameters in a general population. Hum Reprod 2015;30(11):2645–57. DOI: 10.1093/humrep/dev219
63. Durairajanayagam D., Agarwal A., Ong C. Causes, effects and molecular mechanisms of testicular heat stress. Reprod Biomed Online 2015;30(1):14–27. DOI: 10.1016/j.rbmo.2014.09.018
64. Lopez-Casas P.P., Mizrak S.C., López-Fernández L.A. et al. The effects of different endocrine disruptors defining compoundspecific alterations of gene expression profiles in the developing testis. Reprod Toxicol 2012;33(1):106–15. DOI: 10.1016/j.reprotox.2011.12.012
65. Manikkam M., Tracey R., Guerrero-Bosagna C., Skinner M.K. Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS One 2013;8(1):e55387. DOI: 10.1371/journal.pone.0055387
66. Huang X.F., Li Y., Gu Y.H. et al. The effects of Di-(2-ethylhexyl)- phthalate exposure on fertilization and embryonic development in vitro and testicular genomic mutation in vivo. PLoS One 2012;7(11):e50465. DOI: 10.1371/journal.pone.0050465
67. Vogt P.H., Bender U., Deibel B. et al. Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature. Cell Biosci 2021;11(1):60. DOI: 10.1186/s13578-021-00551-2
68. Vogt P.H., Rauschendorf M.A., Zimmer J. et al. AZFa Y gene, DDX3Y, evolved novel testis transcript variants in primates with proximal 3’UTR polyadenylation for germ cell specific translation. Sci Rep 2022;12(1):8954. DOI: 10.1038/s41598-022-12474-0
69. Zhang X.F., Zhang T., Wang L. et al. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep 2013;40(11):6509–17. DOI: 10.1007/s11033-013-2769-y
70. Zhang C., Lai J.H., Hu B. et al. A chromatin modifier regulates Sertoli cell response to mono-(2-ethylhexyl) phthalate (MEHP) via tissue inhibitor of metalloproteinase 2 (TIMP2) signaling. Biochim Biophys Acta 2014;1839(11):1170–82. DOI: 10.1016/j.bbagrm.2014.08.006
71. Gray L.E. Jr., Wilson V.S., Stoker T. et al. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int J Androl 2006;29(1):96–104; discussion 105–8. DOI: 10.1111/j.1365-2605.2005.00636.x
72. Rider C.V., Furr J., Wilson V.S., Gray L.E. Jr. A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl 2008;31(2):249–62. DOI: 10.1111/j.1365-2605.2007.00859.x
73. Sharpe R.M. “Additional” effects of phthalate mixtures on fetal testosterone production. Toxicol Sci 2008;105(1):1–4. DOI: 10.1093/toxsci/kfn123
74. Howdeshell K.L., Furr J., Lambright C.R. et al. Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicol Sci 2007;99(1):190–202. DOI: 10.1093/toxsci/kfm069
Andrology and Genital Surgery. 2023; 24: 19-30
The negative impact of phthalates on male reproductive system and fertility
https://doi.org/10.17650/2070-9781-2023-24-2-19-30Abstract
The paper overviews the negative impact of phthalates on the male reproductive system, spermatogenesis, semen parameters and male fertility. The analysis of the literature revealed few studies devoted to the study of the effect of phthalates on reproductive health, gametogenesis and fertility in humans and laboratory models (rats, mice). Although epidemiological studies on the effect of phthalates on the male reproductive health are not big, some toxicological studies show that some phthalates are potential reprotoxicants.
References
1. Kurilo L.F., Khil'kevich L.V. Sovremennye podkhody k izucheniyu gonado- i gametotoksicheskogo effekta ekzogennykh faktorov. Meditsinskaya genetika, ekspress-informatsiya 1989;9:1–16.
2. RTECS(R) National Institute for Occupational Safety and Health. Canadian Centre for Occupational Health Safety, 2005.
3. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int J Hyg Environ Health 2007;210(5):623–34. DOI: 10.1016/j.ijheh.2007.07.011
4. Koo J.W., Parham F., Kohn M.C. et al. The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ Health Perspect 2002;110(4):405–10. DOI: 10.1289/ehp.02110405
5. Fasano E., Bono-Blay F., Cirillo T. et al. Migration of phthalates, alkylphenols, bisphenol A and di(2-ethylhexyl)adipate from food packaging. Food Control 2012;27(1):132–8. DOI: 10.1016/j.foodcont.2012.03.005
6. Reproductive and developmental toxicology. Ed. by R.C. Gupta. 2nd edn. Academic Press, Elsevier Inc., 2017. 1446 p.
7. Johns L.E., Cooper G.S., Galizia A., Meeker J.D. Exposure assessment issues in epidemiology studies of phthalates. Environ Int 2015;85:27–39. DOI: 10.1016/j.envint.2015.08.005
8. Talsness C.E., Andrade A.J., Kuriyama S.N. et al. Components of plastic: experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B Biol Sci 2009;364(1526): 2079–96. DOI: 10.1098/rstb.2008.0281
9. Sheftel' V.O., Dyshinevich N.E., Sova R.E. Toksikologiya polimernykh materialov. Kiev: Zdorov’ya, 1988. 210 s.
10. Chen X., Xu S., Tan T. et al. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. Int J Environ Res Publ Health 2014;11(3):3156–68.
11. Knez J. Endocrine-disrupting chemicals and male reproductive health. Reprod Biomed Online 2013;26(5):440–8. DOI: 10.1016/j.rbmo.2013.02.005
12. Calafat A.M., Ye X., Silva M.J et al. Human exposure assessment to environmental chemicals using biomonitoring. Int J Androl 2006;29(1):166–71; discussion 181–5. DOI: 10.1111/j.1365-2605.2005.00570.x
13. Rusyn I., Peters J.M, Cunningham ML, Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol 2006;36(5):459–79. DOI: 10.1080/10408440600779065
14. Heindel J.J., Powell C.J. Phthalate ester effects on rat Sertoli cell function in vitro: effects of phthalate side chain and age of animal. Toxicol Appl Pharmacol 1992;115(1):116–23. DOI: 10.1016/0041-008x(92)90374-2
15. Koch H.M., Bolt H.M., Preuss R. et al. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch Toxicol 2005;79(7):367–76. DOI: 10.1007/s00204-004-0642-4
16. Silva M.J., Barr D.B., Reidy J.A. et al. Glucuronidation patterns of common urinary and serum monoester phthalate metabolites. Arch Toxicol 2003;77(10):561–7. DOI: 10.1007/s00204-003-0486-3
17. Frederiksen H., Skakkebaek N.E., Andersson A.M. Metabolism of phthalates in humans. Mol Nutr Food Res 2007;51(7):899–911. DOI: 10.1002/mnfr.200600243
18. Sheftel' V.O., Zinchenko T.M., Kataeva S.E. Sanitarnaya toksikologiya ftalatov, zagryaznitelei vody. Gigiena i sanitariya 1981;8:66–7.
19. Abdel daiem M.M., Rivera-Utrilla J., Ocampo-Pérez R. et al. Environmental impact of phthalic acid esters and their removal from water and sediments by different technologies – a review. J Environ Manage 2012;109:164–78. DOI: 10.1016/j.jenvman.2012.05.014
20. Lawrence W.H. Phthalate esters: the question of safety. Clin Toxicol 1978;13(1):89–139. DOI: 10.3109/15563657808988230
21. Entsiklopediya po bezopasnosti i gigiene truda. Per. s angl., v 4 t. Mezhdunarodnaya organizatsiya truda. Pod red. A.P. Pochinok. 4-e izd. M.: M-vo truda i sots. razvitiya, 2001.
22. Wang Y.X., Liu C., Chen Y.J. et al. Predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men. Environ Res 2018;161:336–44. DOI: 10.1016/j.envres.2017.11.027
23. Duty S.M., Ackerman R.M., Calafat A.M., Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect 2005;113(11):1530–5. DOI: 10.1289/ehp.8083
24. Hauser R., Skakkebaek N.E., Hass U. et al. Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 2015;100(4):1267–77. DOI: 10.1210/jc.2014-4325
25. Fisher J.S., Macpherson S., Marchetti N., Sharpe R.M. Human ‛testicular dysgenesis syndrome’: a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003;18(7):1383–1394. DOI: 10.1093/humrep/deg273
26. Desdoits-Lethimonier C., Albert O., Le Bizec B. et al. Human testis steroidogenesis is inhibited by phthalates. Hum Reprod 2012;27(5):1451–9. DOI: 10.1093/humrep/des069
27. Skinner M.K., Anway M.D. Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors. Ann N Y Acad Sci 2005;1061;18–32. DOI: 10.1196/annals.1336.004
28. Kay V.R., Bloom M.S., Foster W.G. Reproductive and developmental effects of phthalate diesters in males. Crit Rev Toxicol 2014;44(6):467–98. DOI: 10.3109/10408444.2013.875983
29. Gray L.E. Jr., Ostby J., Furr J. et al. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000;58(2):350–65. DOI: 10.1093/toxsci/58.2.350
30. Chiba K., Kondo Y., Yamaguchi K. et al. Inhibition of claudin-11 and occludin expression in rat Sertoli cells by mono-(2-ethylhexyl) phthalate through p44/42 mitogen-activated protein kinase pathway. J Androl 2012;33(3):368–74. DOI: 10.2164/jandrol.111.013664
31. Harris C.A., Henttu P., Parker M.G., Sumpter J.P. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 1997;105(8):802–11. DOI: 10.1289/ehp.97105802
32. Foster P.M. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 2006;29(1):140–7; discussion 181–5. DOI: 10.1111/j.1365-2605.2005.00563.x
33. Dalgaard M., Nellemann C., Lam H.R. et al. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats. Toxicol Lett 2001;122(1):69–79. DOI: 10.1016/s0378-4274(01)00348-4
34. Zhang X.F., Zhang T., Wang L. et al. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep 2013;40(11):6509–17. DOI: 10.1007/s11033-013-2769-y
35. Akingbemi B.T., Youker R.T., Sottas C.M. et al. Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biol Reprod 2001;65(4):1252–9. DOI: 10.1095/biolreprod65.4.1252
36. Wang Y.X., Zeng Q., Sun Y. et al. Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: a cross-sectional study in China. Environ Pollut 2016;211:173–82. DOI: 10.1016/j.envpol.2015.12.052
37. Li X., Fang E.F., Scheibye-Knudsen M. et al. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis. Sci Rep 2014;4:6434. DOI: 10.1038/srep06434
38. Hauser R., Meeker J.D., Singh N.P. et al. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum Reprod 2007;22(3):688–95. DOI: 10.1093/humrep/del428
39. Liu L., Bao H., Liu F. et al. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environ Int 2012;42:78–83. DOI: 10.1016/j.envint.2011.04.005
40. Jurewicz J., Radwan M., Sobala W. et al. Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Reprod Toxicol 2013;42:232–41. DOI: 10.1016/j.reprotox.2013.10.001
41. Jönsson B.A., Richthoff J., Rylander L. et al. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 2005;16(4):487–93. DOI: 10.1097/01.ede.0000164555.19041.01
42. Joensen U.N., Frederiksen H., Blomberg Jensen M. et al. Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. Environ Health Perspect 2012;120(10):1397–403. DOI: 10.1289/ehp.1205113
43. Pant N., Shukla M., Kumar Patel D. et al. Correlation of phthalate exposures with semen quality. Toxicol Appl Pharmacol 2008;231(1):112–6. DOI: 10.1016/j.taap.2008.04.001
44. Wang Y.X., Zeng Q., Sun Y. et al. Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China. Environ Res 2016;150:557–65. DOI: 10.1016/j.envres.2015.11.023
45. Duty S.M., Singh N.P., Silva M.J. et al. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 2003;111(9):1164–9. DOI: 10.1289/ehp.5756
46. Carbone S., Szwarcfarb B., Ponzo O. et al. Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male rats. Neurotoxicology 2010;31(6):747–51. DOI: 10.1016/j.neuro.2010.06.006
47. State of the science of endocrine disrupting chemicals, 2012. Ed. by A. Bergman, J.J. Heindel, S. Jobling et al. UNEP& WHO, Geneva, Switzerland, 2013. 289 p. Available at: https://apps.who.int/iris/handle/10665/78101
48. Gore A.C., Chappell V.A., Fenton S.E. et al. EDC-2: the Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 2015;36(6):E1–E150. DOI: 10.1210/er.2015-1010
49. Levin E.R. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19(8):1951–9. DOI: 10.1210/me.2004-0390
50. Watson S., Alyea R.A., Jeng Y.J., Kochukov M.Y. Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues. Mol Cell Endocrinol 2007;274(1–2):1–7. DOI: 10.1016/j.mce.2007.05.011
51. Silva E., Kabil A., Kortenkamp A. Cross-talk between non-genomic and genomic signaling pathways – distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol 2010;245(2):160–70. DOI: 10.1016/j.taap.2010.02.015
52. Nadal A., Díaz M., Valverde M.A. The estrogen trinity: membrane, cytosolic, and nuclear effects. News Physiol Sci 2001;16:251–5. DOI: 10.1152/physiologyonline.2001.16.6.251
53. Takayanagi S., Tokunaga T., Liu X. et al. Endocrine disruptor bisphenol A strongly binds to human estrogen-related gamma receptor (ERRgamma) with high constitutive activity. Toxicol Lett 2006;167(2):95–105. DOI: 10.1016/j.toxlet.2006.08.012
54. Ho T.S.M., Tang W.Y., Belmonte de Frausto J., Prins G.S. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 2006;66(11):5624–32. DOI: 10.1158/0008-5472.CAN-06-0516
55. Whitehead S., Rice S. Endocrine-disrupting chemicals as modulators of sex steroid synthesis. Best Pract Res Clin Endocrinol Metab 2006;20(1):45–61. DOI: 10.1016/j.beem.2005.09.003
56. Lovekamp-Swan T., Jetten A.M., Davis B.J. Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Mol Cell Endocrinol 2003;201(1–2): 133–41. DOI: 10.1016/s0303-7207(02)00423-9
57. Gunnarsson D., Leffler P., Ekwurtzel E. et al. Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes. Reproduction 2008;135(5):693–703. DOI: 10.1530/REP-07-0460
58. Zhao Y., Ao H., Chen L. et al. Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation. Toxicol In Vitro 2012;26(6):950–5. DOI: 10.1016/j.tiv.2012.04.003
59. Barlow N.J., Phillips S.L., Wallace D.G. et al. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci 2003;73(2):431–41. DOI: 10.1093/toxsci/kfg087
60. Li L.H., Jester W.F. Jr., Laslett A.L., Orth J.M. A single dose of Di- (2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol 2000;166(3):222–9. DOI: 10.1006/taap.2000.8972
61. Tay T.W., Andriana B.B., Ishii M. et al. Disappearance of vimentin in Sertoli cells: a mono(2-ethylhexyl) phthalate effect. Int J Toxicol 2007;26(4):289–95. DOI: 10.1080/00207450701470757
62. Bloom M.S., Whitcomb B.W., Chen Z. et al. Associations between urinary phthalate concentrations and semen quality parameters in a general population. Hum Reprod 2015;30(11):2645–57. DOI: 10.1093/humrep/dev219
63. Durairajanayagam D., Agarwal A., Ong C. Causes, effects and molecular mechanisms of testicular heat stress. Reprod Biomed Online 2015;30(1):14–27. DOI: 10.1016/j.rbmo.2014.09.018
64. Lopez-Casas P.P., Mizrak S.C., López-Fernández L.A. et al. The effects of different endocrine disruptors defining compoundspecific alterations of gene expression profiles in the developing testis. Reprod Toxicol 2012;33(1):106–15. DOI: 10.1016/j.reprotox.2011.12.012
65. Manikkam M., Tracey R., Guerrero-Bosagna C., Skinner M.K. Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS One 2013;8(1):e55387. DOI: 10.1371/journal.pone.0055387
66. Huang X.F., Li Y., Gu Y.H. et al. The effects of Di-(2-ethylhexyl)- phthalate exposure on fertilization and embryonic development in vitro and testicular genomic mutation in vivo. PLoS One 2012;7(11):e50465. DOI: 10.1371/journal.pone.0050465
67. Vogt P.H., Bender U., Deibel B. et al. Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature. Cell Biosci 2021;11(1):60. DOI: 10.1186/s13578-021-00551-2
68. Vogt P.H., Rauschendorf M.A., Zimmer J. et al. AZFa Y gene, DDX3Y, evolved novel testis transcript variants in primates with proximal 3’UTR polyadenylation for germ cell specific translation. Sci Rep 2022;12(1):8954. DOI: 10.1038/s41598-022-12474-0
69. Zhang X.F., Zhang T., Wang L. et al. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep 2013;40(11):6509–17. DOI: 10.1007/s11033-013-2769-y
70. Zhang C., Lai J.H., Hu B. et al. A chromatin modifier regulates Sertoli cell response to mono-(2-ethylhexyl) phthalate (MEHP) via tissue inhibitor of metalloproteinase 2 (TIMP2) signaling. Biochim Biophys Acta 2014;1839(11):1170–82. DOI: 10.1016/j.bbagrm.2014.08.006
71. Gray L.E. Jr., Wilson V.S., Stoker T. et al. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int J Androl 2006;29(1):96–104; discussion 105–8. DOI: 10.1111/j.1365-2605.2005.00636.x
72. Rider C.V., Furr J., Wilson V.S., Gray L.E. Jr. A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl 2008;31(2):249–62. DOI: 10.1111/j.1365-2605.2007.00859.x
73. Sharpe R.M. “Additional” effects of phthalate mixtures on fetal testosterone production. Toxicol Sci 2008;105(1):1–4. DOI: 10.1093/toxsci/kfn123
74. Howdeshell K.L., Furr J., Lambright C.R. et al. Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicol Sci 2007;99(1):190–202. DOI: 10.1093/toxsci/kfm069
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