Андрология и генитальная хирургия. 2022; 23: 55-63
Анатомические особенности порока, методы и результаты первичного закрытия экстрофии мочевого пузыря. Обзор литературы
Рудин А. Ю., Рудин Ю. Э., Соколов Ю. Ю.
https://doi.org/10.17650/2070-9781-2022-23-4-55-63Аннотация
Введение. Экстрофия мочевого пузыря (ЭМП) – сложный сочетанный порок развития органов мочеполовой системы, методы лечения которого до конца не разработаны.
Материалы и методы. При написании обзора литературы были использованы материалы, посвященные проблеме ЭМП, найденные в базах данных PubMed, еLIBRARY (российская научная электронная библиотека), Scopus, Medline, EMBASE, на веб-сайтах и в журналах зарубежных и отечественных профессиональных ассоциаций.
Результаты. Множественные анатомические особенности строения органов и целых систем делают ЭМП одним из самых сложнокорригируемых врожденных пороков в области детской урологии, требующих комплексного, системного подхода к диагностике и лечению. В работе отражены ключевые, по нашему мнению, аспекты авторских операций Kelly, Mainz, подходов Schrott–Erlangen, CPRE, MSRE, а также взгляды ряда авторов на остеотомию.
Заключение. Изобилие техник первичного закрытия ЭМП и различия во взглядах многих авторов на необходимый объем оперативного вмешательства, представленные в данном обзоре литературы, являются неоспоримым доказательством актуальности проблемы.
Список литературы
1. Feneley M., Gearhart J.P. A history of bladder and cloacal exstrophy [abstract]. American Urological Association Annual Meeting, May 1, 2000, Anaheim, California.
2. Gearhart J.P., Di Carlo H.N. Exstrophy-epispadias complex. In: Partin A.W., Wein A.J., Kavoussi L.R. et al. Campbell Walsh Wein Urology, E-Book. Elsevier Health Sciences, 2020. Pp. 528–580.
3. Nelson C.P., Dunn R.L., Wei J.T. Contemporary epidemiology of bladder exstrophy in the United States. J Urol 2005;173(5):1728–31. DOI: 10.1097/01.ju.0000154821.21521.9b
4. Siffel C., Correa A., Amar E. et al. An epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature. Am J Med Genet C Semin Med Genet 2011;157(4):321–2. DOI: 10.1002/ajmg.c.30316
5. Shapiro E., Lepor H., Jeffs R.D. The inheritance of the exstrophyepispadias complex. J Urol 1984;132(2):308–10. DOI: 10.1016/s0022-5347(17)49605-4
6. Ives E., Coffey R., Carter C.O. A family study of bladder exstrophy. J Med Genet 1980;17(2):139–41. DOI: 10.1136/jmg.17.2.139
7. Wood H.P., Trock B.P., Gearhart J.P. In vitro fertilization and the cloacal-bladder exstrophy-epispadias complex: is there an association? J Urol 2003;169(4):1512–5. DOI: 10.1097/01.ju.0000054984.76384.66
8. Muecke E.C. The role of the cloacal membrane in exstrophy: the first successful experimental study. J Urol 1964;92(6):659–68. DOI: 10.1016/s0022-5347(17)64028-x
9. Ambrose S.S., O’Brien D.P. 3rd. Surgical embryology of the exstrophy-epispadias complex. Surg Clin North Am 1974;54(6):1379–90. DOI: 10.1016/s0039-6109(16)40493-7
10. Mildenberger H., Kluth D., Dziuba M. Embryology of bladder exstrophy. J Pediatr Surg 1988;23(2):166–70. DOI: 10.1016/s0022-3468(88)80150-7
11. Beaudoin S., Simon L., Bargy F. Anatomical basis of the common embryological origin for epispadias and bladder or cloacal exstrophy. Surg Radiol Anat 1997;19(1):11–6. DOI: 10.1007/BF01627728
12. Silver R.I., Yang A., Ben-Chaim J. et al. Penile length in adulthood after exstrophy reconstruction. J Urol 1997;157(3):999–1003. DOI: 10.1016/S0022-5347(01)65131-0
13. Dunn E.A., Kasprenski M., Facciola J. et al. Anatomy of classic bladder exstrophy: MRI findings and surgical correlation. Curr Urol Rep 2019;20(9):48. DOI: 10.1007/s11934-019-0916-2
14. Perovic S.V., Djinovic R.P. New insight into surgical anatomy of epispadiac penis and its impact on repair. J Urol 2008;179(2):689– 95; discussion 695–6. DOI: 10.1016/j.juro.2007.09.105
15. Schlegel P.N., Gearhart J.P. Neuroanatomy of the pelvis in an infant with cloacal exstrophy: a detailed microdissection with histology. J Urol 1989;141(3):583–5. DOI: 10.1016/s0022-5347(17)40901-3
16. Stein R., Hohenfellner K., Fisch M. et al. Social integration, sexual behaviour and fertility in patients with bladder exstrophy – a long-term follow up. Eur J Pediatr 1996;155(8):678–83. DOI: 10.1007/BF01957152
17. Рудин Ю.Э., Соколов Ю.Ю., Рудин А.Ю. и др. Объем операции при первичном закрытии мочевого пузыря у детей с экстрофией мочевого пузыря. Детская хирургия 2020;24(1):21–8. DOI: 10.18821/1560-9510-2020-24-1-21-28
18. Рудин Ю.Э., Соколов Ю.Ю., Рудин А.Ю. и др. Отсроченное первичное закрытие мочевого пузыря у детей с экстрофией и микроцистисом. Экспериментальная и клиническая урология 2020;4;146–54. DOI: 10.29188/2222-8543-2020-13-4-146-154
19. Shapiro E., Jeffs R.D., Gearhart J.P., Lepor H. Muscarinic cholinergic receptors in bladder exstrophy: insights into surgical management. J Urol 1985;134(2):308–10. DOI: 10.1016/s0022-5347(17)47139-4
20. Mathews R.I., Wills M., Perlman E., Gearhart G.P. Neural innervation of the newborn exstrophic bladder: an immunohistochemical study. J Urol 1999;162(2):506–8.
21. Gearhart J.P., Jeffs R.D. The bladder exstrophy-epispadias complex. In: Campbell’s urology, 3rd edn. Ed. by P.C. Walsh et al. Philadelphia, 1998.
22. Stec A.A., Baradaran N., Schaeffer A. et al. The modern staged repair of classic bladder exstrophy: a detailed postoperative management strategy for primary bladder closure. J Pediatr Urol 2012;8(5):549–55. DOI: 10.1016/j.jpurol.2011.09.007
23. Schaeffer A.J., Stec A.A., Baradaran N. et al. Preservation of renal function in the modern staged repair of classic bladder exstrophy. J Pediatr Urol 2013;9(2):169–73. DOI: 10.1016/j.jpurol.2012.01.014
24. Sponseller P.D., Bisson L.J., Gearhart J.P. et al. The anatomy of the pelvis in the exstrophy complex. J Bone Joint Surg Am 1995;77(2):177–89. DOI: 10.2106/00004623-199502000-00003
25. Williams A.M., Solaiyappan M., Pannu H.K. et al. 3-dimensional magnetic resonance imaging modeling of the pelvic floor musculature in classic bladder exstrophy before pelvic osteotomy. J Urol 2004;172(4 Pt 2):1702–5. DOI: 10.1097/01.ju.0000140212.56826.4c
26. Stec A.A., Tekes A., Ertan G. et al. Evaluation of pelvic floor muscular redistribution after primary closure of classic bladder exstrophy by 3-dimensional magnetic resonance imaging. J Urol 2012;188(4 Suppl):1535–42. DOI: 10.1016/j.juro.2012.02.039
27. Рудин Ю.Э., Марухненко Д.В., Чекериди Ю.Э. и др. Способы коррекции экстрофии мочевого пузыря у детей. Детская хирургия 2009;4:18–22.
28. Connolly J.A., Peppas D.S., Jeffs R.D., Gearhart J.P. Prevalence in repair of inguinal hernias in children with bladder exstrophy. J Urol 1995;154(5):1900–1.
29. Lavien G., Di Carlo H.N., Shah B.B. et al. Impact of pelvic osteotomy on the incidence of inguinal hernias in classic bladder exstrophy. J Pediatr Surg 2014;49(10):1496–9. DOI: 10.1016/j.jpedsurg.2014.05.012
30. Stec A.A., Baradaran N., Tran C., Gearhart J.P. Colorectal anomalies in patients with classic bladder exstrophy. J Pediatr Surg 2011;46(9):1790–3. DOI: 10.1016/j.jpedsurg.2011.03.019
31. Gearhart J.P., Ben-Chaim J., Jeffs R.D., Sanders B.C. Criteria for the prenatal diagnosis of classic bladder exstrophy. Obstet Gynecol 1995;85(6):961–4. DOI: 10.1016/0029-7844(95)00069-4
32. Baradaran N., Cervellione R.M., Stec A.A., Gearhart J.P. Delayed primary repair of bladder exstrophy: ultimate effect on growth. J Urol 2012;188(6):2336–41. DOI: 10.1016/j.juro.2012.08.037
33. Ferrara F., Dickson A.P., Fishwick J. et al. Delayed exstrophy repair (DER) does not compromise initial bladder development. J Pediatr Urol 2014;10(3):506–10. DOI: 10.1016/j.jpurol.2013.10.026
34. Sweetser T.H., Chisholm T.C., Thompson W.H. Exstrophy of the urinary bladder: discussion of anatomical and surgical principles applicable to its repair, with a preliminary report of a case. Minn Med 1952;35(7):654–7.
35. Cendron J. [Bladder reconstruction. Method derived from that of Trendelenbourg (In French)]. Ann Chir Infant 1971;12(6):371–81.
36. Jeffs R.D., Charrios R., Mnay M. et al. Primary closure of the exstrophied bladder. In: Current controversies in urologic management. Ed. by R. Scott. Philadelphia: WB Saunders, 1972. P. 235.
37. Williams D.I., Keaton J. Vesical exstrophy: twenty years’ experience. Br J Surg 1973;60:203.
38. Kelly J.H. Vesical exstrophy: repair using radical mobilisation of soft tissues. Pediatr Surg Int 1995;10(5):298–304.
39. Ansell J.E. Exstrophy and epispadias. In: Urologic surgery. Ed. by J.F. Glenn. Philadelphia: JB Lippincott, 1983. 647 p.
40. Schrott K.M., Siegel A., Schrott G. Fruhzeitige total reconstruktion der blasenexstrophie. In: Deutschland urology (vol. 35). Ed. by R. Rodeck. Berlin: Springer, 1984. Pp. 383–386.
41. Stein R., Fisch M., Black P., Hohenfellner R. Strategies for reconstruction after unsuccessful or unsatisfactory primary treatment of patients with bladder exstrophy or incontinent epispadias. J Urol 1999;161(6):1934–41.
42. Gobet R., Weber D., Renzulli P., Kellenberger C. Long-term follow up (37–69 years) of patients with bladder exstrophy treated with ureterosigmoidostomy: uro-nephrological outcome. J Pediatr Urol 2009;5(3):190–6. DOI: 10.1016/j.jpurol.2008.11.007
43. Spence H.M., Hoffman W.W., Fosmire G.P. Tumour of the colon as a late complication of ureterosigmoidostomy for exstrophy of the bladder. Br J Urol 1979;51(6):466–70. DOI: 10.1111/j.1464-410x.1979.tb03580.x
44. Grady R., Mitchell M.E. Complete primary repair of exstrophy. J Urol 1999;162(4):1415–20.
45. Baird A.D., Mathews R.I., Gearhart J.P. The use of combined bladder and epispadias repair in boys with classic bladder exstrophy: outcomes, complications and consequences. J Urol 2005;174(4 Pt 1): 1421–4. DOI: 10.1097/01.ju.0000173127.81878.2b
46. Ebert A.K., Schott G., Bals-Pratsch M. et al. Long-term follow-up of male patients after reconstruction of the bladder-exstrophyepispadias complex: psychosocial status, continence, renal and genital function. J Pediatr Urol 2010;6(1):6–10. DOI: 10.1016/j.jpurol.2009.06.002
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54. Ebert A.K., Rösch W. Paediatric urology: is osteotomy necessary for primary exstrophy closure? Nat Rev Urol 2013;10(11):625–6. DOI: 10.1038/nrurol.2013.237
55. Николаев В.В., Демин Н.В., Ладыгина Е.А. Отсроченное хирургическое лечение детей с экстрофией без аппроксимации лонных костей, использования перемещенных лоскутов и иммобилизации пациента. Российский вестник детской хирургии, анестезиологии и реаниматологии 2021;11(4):445–54. DOI: 10.17816/psaic1031
Andrology and Genital Surgery. 2022; 23: 55-63
Anatomical features of the malformation, methods and results of bladder exstrophy primary closure. Literature review
Rudin A. Yu., Rudin Yu. E., Sokolov Yu. Yu.
https://doi.org/10.17650/2070-9781-2022-23-4-55-63Abstract
Background. Bladder exstrophy (ВE) is a complex combined malformation of the organs of the genitourinary system, the methods of treatment of which have not been fully developed.
Materials and methods. When writing a literature review, materials devoted to the problem of BE published in the databases of PubMed, eLIBRARY (the scientific electronic library of Russia), Scopus, Medline, EMBASE, websites and journals of foreign and domestic professional associations were used.
Results. Multiple anatomical features of the structure of organs and entire systems make BE one of the most difficult-to-correct congenital malformations in the field of pediatric urology, requiring a comprehensive, systematic approach to diagnosis and treatment. The paper reflects the key, in our opinion, positions of the author’s Kelly, Mainz operations, the approaches of Schrott–Erlangen, CPRE, MSRE, as well as the view of a number of authors on osteotomy.
Conclusion. The abundance of primary closure techniques and the difference in views of numerous authors on the required amount ofsurgical intervention presented in thisliterature review are indisputable proof ofthe relevance ofthe problem.
References
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2. Gearhart J.P., Di Carlo H.N. Exstrophy-epispadias complex. In: Partin A.W., Wein A.J., Kavoussi L.R. et al. Campbell Walsh Wein Urology, E-Book. Elsevier Health Sciences, 2020. Pp. 528–580.
3. Nelson C.P., Dunn R.L., Wei J.T. Contemporary epidemiology of bladder exstrophy in the United States. J Urol 2005;173(5):1728–31. DOI: 10.1097/01.ju.0000154821.21521.9b
4. Siffel C., Correa A., Amar E. et al. An epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature. Am J Med Genet C Semin Med Genet 2011;157(4):321–2. DOI: 10.1002/ajmg.c.30316
5. Shapiro E., Lepor H., Jeffs R.D. The inheritance of the exstrophyepispadias complex. J Urol 1984;132(2):308–10. DOI: 10.1016/s0022-5347(17)49605-4
6. Ives E., Coffey R., Carter C.O. A family study of bladder exstrophy. J Med Genet 1980;17(2):139–41. DOI: 10.1136/jmg.17.2.139
7. Wood H.P., Trock B.P., Gearhart J.P. In vitro fertilization and the cloacal-bladder exstrophy-epispadias complex: is there an association? J Urol 2003;169(4):1512–5. DOI: 10.1097/01.ju.0000054984.76384.66
8. Muecke E.C. The role of the cloacal membrane in exstrophy: the first successful experimental study. J Urol 1964;92(6):659–68. DOI: 10.1016/s0022-5347(17)64028-x
9. Ambrose S.S., O’Brien D.P. 3rd. Surgical embryology of the exstrophy-epispadias complex. Surg Clin North Am 1974;54(6):1379–90. DOI: 10.1016/s0039-6109(16)40493-7
10. Mildenberger H., Kluth D., Dziuba M. Embryology of bladder exstrophy. J Pediatr Surg 1988;23(2):166–70. DOI: 10.1016/s0022-3468(88)80150-7
11. Beaudoin S., Simon L., Bargy F. Anatomical basis of the common embryological origin for epispadias and bladder or cloacal exstrophy. Surg Radiol Anat 1997;19(1):11–6. DOI: 10.1007/BF01627728
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15. Schlegel P.N., Gearhart J.P. Neuroanatomy of the pelvis in an infant with cloacal exstrophy: a detailed microdissection with histology. J Urol 1989;141(3):583–5. DOI: 10.1016/s0022-5347(17)40901-3
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20. Mathews R.I., Wills M., Perlman E., Gearhart G.P. Neural innervation of the newborn exstrophic bladder: an immunohistochemical study. J Urol 1999;162(2):506–8.
21. Gearhart J.P., Jeffs R.D. The bladder exstrophy-epispadias complex. In: Campbell’s urology, 3rd edn. Ed. by P.C. Walsh et al. Philadelphia, 1998.
22. Stec A.A., Baradaran N., Schaeffer A. et al. The modern staged repair of classic bladder exstrophy: a detailed postoperative management strategy for primary bladder closure. J Pediatr Urol 2012;8(5):549–55. DOI: 10.1016/j.jpurol.2011.09.007
23. Schaeffer A.J., Stec A.A., Baradaran N. et al. Preservation of renal function in the modern staged repair of classic bladder exstrophy. J Pediatr Urol 2013;9(2):169–73. DOI: 10.1016/j.jpurol.2012.01.014
24. Sponseller P.D., Bisson L.J., Gearhart J.P. et al. The anatomy of the pelvis in the exstrophy complex. J Bone Joint Surg Am 1995;77(2):177–89. DOI: 10.2106/00004623-199502000-00003
25. Williams A.M., Solaiyappan M., Pannu H.K. et al. 3-dimensional magnetic resonance imaging modeling of the pelvic floor musculature in classic bladder exstrophy before pelvic osteotomy. J Urol 2004;172(4 Pt 2):1702–5. DOI: 10.1097/01.ju.0000140212.56826.4c
26. Stec A.A., Tekes A., Ertan G. et al. Evaluation of pelvic floor muscular redistribution after primary closure of classic bladder exstrophy by 3-dimensional magnetic resonance imaging. J Urol 2012;188(4 Suppl):1535–42. DOI: 10.1016/j.juro.2012.02.039
27. Rudin Yu.E., Marukhnenko D.V., Chekeridi Yu.E. i dr. Sposoby korrektsii ekstrofii mochevogo puzyrya u detei. Detskaya khirurgiya 2009;4:18–22.
28. Connolly J.A., Peppas D.S., Jeffs R.D., Gearhart J.P. Prevalence in repair of inguinal hernias in children with bladder exstrophy. J Urol 1995;154(5):1900–1.
29. Lavien G., Di Carlo H.N., Shah B.B. et al. Impact of pelvic osteotomy on the incidence of inguinal hernias in classic bladder exstrophy. J Pediatr Surg 2014;49(10):1496–9. DOI: 10.1016/j.jpedsurg.2014.05.012
30. Stec A.A., Baradaran N., Tran C., Gearhart J.P. Colorectal anomalies in patients with classic bladder exstrophy. J Pediatr Surg 2011;46(9):1790–3. DOI: 10.1016/j.jpedsurg.2011.03.019
31. Gearhart J.P., Ben-Chaim J., Jeffs R.D., Sanders B.C. Criteria for the prenatal diagnosis of classic bladder exstrophy. Obstet Gynecol 1995;85(6):961–4. DOI: 10.1016/0029-7844(95)00069-4
32. Baradaran N., Cervellione R.M., Stec A.A., Gearhart J.P. Delayed primary repair of bladder exstrophy: ultimate effect on growth. J Urol 2012;188(6):2336–41. DOI: 10.1016/j.juro.2012.08.037
33. Ferrara F., Dickson A.P., Fishwick J. et al. Delayed exstrophy repair (DER) does not compromise initial bladder development. J Pediatr Urol 2014;10(3):506–10. DOI: 10.1016/j.jpurol.2013.10.026
34. Sweetser T.H., Chisholm T.C., Thompson W.H. Exstrophy of the urinary bladder: discussion of anatomical and surgical principles applicable to its repair, with a preliminary report of a case. Minn Med 1952;35(7):654–7.
35. Cendron J. [Bladder reconstruction. Method derived from that of Trendelenbourg (In French)]. Ann Chir Infant 1971;12(6):371–81.
36. Jeffs R.D., Charrios R., Mnay M. et al. Primary closure of the exstrophied bladder. In: Current controversies in urologic management. Ed. by R. Scott. Philadelphia: WB Saunders, 1972. P. 235.
37. Williams D.I., Keaton J. Vesical exstrophy: twenty years’ experience. Br J Surg 1973;60:203.
38. Kelly J.H. Vesical exstrophy: repair using radical mobilisation of soft tissues. Pediatr Surg Int 1995;10(5):298–304.
39. Ansell J.E. Exstrophy and epispadias. In: Urologic surgery. Ed. by J.F. Glenn. Philadelphia: JB Lippincott, 1983. 647 p.
40. Schrott K.M., Siegel A., Schrott G. Fruhzeitige total reconstruktion der blasenexstrophie. In: Deutschland urology (vol. 35). Ed. by R. Rodeck. Berlin: Springer, 1984. Pp. 383–386.
41. Stein R., Fisch M., Black P., Hohenfellner R. Strategies for reconstruction after unsuccessful or unsatisfactory primary treatment of patients with bladder exstrophy or incontinent epispadias. J Urol 1999;161(6):1934–41.
42. Gobet R., Weber D., Renzulli P., Kellenberger C. Long-term follow up (37–69 years) of patients with bladder exstrophy treated with ureterosigmoidostomy: uro-nephrological outcome. J Pediatr Urol 2009;5(3):190–6. DOI: 10.1016/j.jpurol.2008.11.007
43. Spence H.M., Hoffman W.W., Fosmire G.P. Tumour of the colon as a late complication of ureterosigmoidostomy for exstrophy of the bladder. Br J Urol 1979;51(6):466–70. DOI: 10.1111/j.1464-410x.1979.tb03580.x
44. Grady R., Mitchell M.E. Complete primary repair of exstrophy. J Urol 1999;162(4):1415–20.
45. Baird A.D., Mathews R.I., Gearhart J.P. The use of combined bladder and epispadias repair in boys with classic bladder exstrophy: outcomes, complications and consequences. J Urol 2005;174(4 Pt 1): 1421–4. DOI: 10.1097/01.ju.0000173127.81878.2b
46. Ebert A.K., Schott G., Bals-Pratsch M. et al. Long-term follow-up of male patients after reconstruction of the bladder-exstrophyepispadias complex: psychosocial status, continence, renal and genital function. J Pediatr Urol 2010;6(1):6–10. DOI: 10.1016/j.jpurol.2009.06.002
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