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Андрология и генитальная хирургия. 2022; 23: 68-77

Стриктуры уретры у мальчиков после лечения гипоспадии: заместительная буккальная уретропластика

Ладыгина Е. А., Демин Н. В., Николаев В. В.

https://doi.org/10.17650/2070-9781-2022-23-2-68-77

Аннотация

Введение. Наиболее распространенной причиной возникновения стриктур уретры у мальчиков являются осложнения лечения гипоспадии. Протяженные и осложненные стриктуры представляют самый сложный сегмент проблемы и вопросов выбора метода хирургической коррекции.

Цель работы – рассмотрение техники и результатов заместительной уретропластики буккальным трансплантатом при стриктурах уретры, возникших после лечения гипоспадии в детском возрасте.

Материалы и методы. Ретроспективное исследование проведено в ГБУЗ «Научно-исследовательский институт неотложной детской хирургии и травматологии» Департамента здравоохранения города Москвы с 2017 по 2020 г. Были изучены истории болезни 34 пациентов, перенесших этапную заместительную буккальную уретропластику по поводу осложненной стриктуры уретры. В ходе обследования выявляли осложнения, такие как Lichen sclerosus, короткая уретра, свищи, дивертикулы, множественные (двойные) и протяженные стриктуры.

Результаты. Осложнения возникли у 3 (8,8 %) пациентов: у 2 детей возник кожно-уретральный свищ, у 1 ребенка произошло частичное рубцевание свободного трансплантата. Отдаленные результаты оценены в среднем через 16 мес. Опыт лечения 34 пациентов детского и подросткового возраста с постгипоспадическими стриктурами показал, что ведущей причиной образования стриктур после лечения гипоспадии является Lichen sclerosus, встретившийся у 16 пациентов. 

Заключение. В течение последнего столетия было предложено множество донорских тканей для свободной пластики уретры, однако именно буккальный трансплантат приобрел наибольшее число сторонников, а этапная уретропластика стала методом выбора при стриктурах передней уретры. Значительный опыт хирурга в выполнении буккальной уретропластики, соблюдение нюансов техники и методики ведения пациента в послеоперационном периоде как на 1-м, так и на 2-м этапе лечения позволяют получить хороший косметический и функциональный результат даже после ряда неудачных операций.

Список литературы

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2. Vetterlein M.W., Weisbach L., Riechardt S., Fisch M. Anterior urethral strictures in children: disease etiology and comparative effectiveness of endoscopic treatment vs. open surgical reconstruction. Front Pediatr 2019;7:5. DOI: 10.3389/fped.2019.00005.

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4. Latini J.M., McAninch J.W., Brandes S.B. et al. SIU/ICUD consultation on urethral strictures: epidemiology, etiology, anatomy, and nomenclature of urethral stenoses, strictures, and pelvic fracture urethral disruption injuries. Urology 2014;83(3 Suppl):S1–7. DOI: 10.1016/j.urology.2013.09.009.

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6. Campos-Juanatey F., Osman N.I., Greenwell T. et al. European Association of Urology Guidelines on Urethral Stricture Disease (Part 2): Diagnosis, Perioperative Management, and Followup in Males. Eur Urol 2021;80(2):2012–12. DOI: 10.1016/j.eururo.2021.05.032.

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8. Fistarol S.K,, Itin P.H. Diagnosis and treatment of lichen sclerosus: an update. J Clin Dermatol 2013;14(1):27–47. DOI: 10.1007/s40257-012-0006-4.

9. Kirtschig G. Lichen sclerosuspresentation, diagnosis and management. Dtsch Arztebl Int 2016;113(19):337–43. DOI: 10.3238/arztebl.2016.0337.

10. Gittes R.F., McLaughiin A.P. 3rd. Injection technique to induce penile erection. Urology 1974;4(4):473–4. DOI: 10.1016/0090-4295(74)90025-9.

11. Wolffenbuttel K.P., Wondergem N., Hoefnagels J.J. et al. Abnormal urine flow in boys with distal hypospadias before and after correction. J Urol 2006;176(4 Pt 2):1733–6; discussion 1736–7. DOI: 10.1016/S0022-5347(06)00614-8.

12. Rynja S.P., de Jong T.P., Bosch J.L., de Kort L.M. Functional, cosmetic and psychosexual results in adult men who underwent hypospadias correction in childhood. J Pediatr Urol 2011;7(5): 504–15. DOI: 10.1016/j.jpurol.2011.02.008.

13. Nuininga J.E., De Gier R.P., Verschuren R., Feitz W.F. Long-term outcome of different types of 1-stage hypospadias repair. J Urol 2005;174(4 Pt 2):1544–8; discussion 1548. DOI: 10.1097/01.ju.0000179255.55848.50.

14. Myers J.B., McAninch J.W., Erickson B.A., Breyer B.N. Treatment of adults with complications from previous hypospadias surgery. J Urol 2012;188(2):459–63. DOI: 10.1016/j.juro.2012.04.007.

15. Mattioli G., Repetto P., Carlini C. et al. Lichen sclerosus et atrophicus in children with phimosis and hypospadias. Pediatr Surg Int 2002;18(4):273–5. DOI: 10.1007/s003830100699.

16. Rourke K., Braga L.H. Transitioning patients with hypospadias and other penile abnormalities to adulthood: What to expect? Can Urol Assoc J 2018;12 (4 Suppl 1):S27–33. DOI: 10.5489/cuaj.5227.

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18. Badawy H., Soliman A., Moussa A. et al. Staged repair of redo and crippled hypospadias: analysis of outcomes and complications. J Pediatr Urol 2019;15(2):151.e1–151.e10. DOI: 10.1016/j.jpurol.2019.01.002.

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20. Pandey A., Barta-Kelemen A.M., Borisenkov M., Keller H. The staged urethroplasty with vascularised scrotal flap and buccal mucosa graft after failed hypospadias surgery: a reliable technique with a Novel Tool. Urol Int 2017;99(1): 36–42. DOI: 10.1159/000464107.

21. Gill N.A., Hameed A. Management of hypospadias cripples with two-staged Bracka’s technique. J Plast Reconstr Aesthet Surg 2011;64(1):91–6. DOI: 10.1016/j.bjps.2010.02.033.

22. Djordjevic M.L. Graft surgery in extensive urethral stricture disease. Curr Urol Rep 2014;15(8):424. DOI: 10.1007/s11934-014-0424-3.

23. Fasolis M., Zavattero, E., Sedigh O. et al. Oral mucosa harvest for urologic reconstruction: role of maxillofacial surgeon and donor-site morbidity evaluation. J Craniofac Surg 2014;25(2):604–6. DOI: 10.1097/SCS.0000000000000687.

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Andrology and Genital Surgery. 2022; 23: 68-77

Urethral strictures in boys after hypospadias treatment: two-staged buccal urethroplasty

Ladygina E. A., Demin N. V., Nikolaev V. V.

https://doi.org/10.17650/2070-9781-2022-23-2-68-77

Abstract

Introduction. The most common cause of urethral strictures in boys is a complication of hypospadias treatment. Extended and complicated strictures represent the most difficult segment of the problem and the choice of the method of surgical correction.

The study objective is to review the technique and results of replacement urethroplasty with buccal graft in urethral strictures that occurred after treatment of hypospadias in childhood.

Materials and methods. A retrospective study conducted at the Clinical and Research Institute of Emergency Pediatric Surgery and Trauma from 2017 to 2020. Cases of 34 patients who underwent staged replacement buccal urethroplasty for complicated urethral stricture were studied. The examination revealed complications such as: Lichen sclerosus, short urethra, fistulas, diverticula, multiple (double) and extended strictures.

Results. Complications occurred in 3 (8.8 %) patients: cutaneous urethral fistula developed in two, partial scarring of the free graft occurred in one child. Long-term results were assessed after an average of 16 months. Our experience of treating 34 pediatric and adolescent patients with p after-hypospadias strictures showed that the leading cause of stricture formation after hypospadias treatment is Lichen sclerosus, which occurred in 16 patients.

Conclusion. During the last century, many donor tissues have been proposed for free urethroplasty, but it is the buccal graft that has won the largest number of supporters, and two-staged urethroplasty has become the method of choice for strictures of the anterior urethra. The surgeon’s considerable experience in performing buccal urethroplasty, adherence to the nuances of the technique and methodology of postoperative management, both at the first and second stages, allows you to obtain a good cosmetic and functional result even after a number of unsuccessful operations.

References

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2. Vetterlein M.W., Weisbach L., Riechardt S., Fisch M. Anterior urethral strictures in children: disease etiology and comparative effectiveness of endoscopic treatment vs. open surgical reconstruction. Front Pediatr 2019;7:5. DOI: 10.3389/fped.2019.00005.

3. Barbagli G., Perovic S., Djinovic R. et al. Retrospective descriptive analysis of 1,176 patients with failed hypospadias repair. J Urol 2010;183(1):207–11. DOI: 10.1016/j.juro.2009.08.153.

4. Latini J.M., McAninch J.W., Brandes S.B. et al. SIU/ICUD consultation on urethral strictures: epidemiology, etiology, anatomy, and nomenclature of urethral stenoses, strictures, and pelvic fracture urethral disruption injuries. Urology 2014;83(3 Suppl):S1–7. DOI: 10.1016/j.urology.2013.09.009.

5. Lumen N., Hoebeke P., Willemsen P. et al. Etiology of urethral stricture disease in the 21st century. J Urol 2009;182(3): 983–7. DOI: 10.1016/j.juro.2009.05.023.

6. Campos-Juanatey F., Osman N.I., Greenwell T. et al. European Association of Urology Guidelines on Urethral Stricture Disease (Part 2): Diagnosis, Perioperative Management, and Followup in Males. Eur Urol 2021;80(2):2012–12. DOI: 10.1016/j.eururo.2021.05.032.

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8. Fistarol S.K,, Itin P.H. Diagnosis and treatment of lichen sclerosus: an update. J Clin Dermatol 2013;14(1):27–47. DOI: 10.1007/s40257-012-0006-4.

9. Kirtschig G. Lichen sclerosuspresentation, diagnosis and management. Dtsch Arztebl Int 2016;113(19):337–43. DOI: 10.3238/arztebl.2016.0337.

10. Gittes R.F., McLaughiin A.P. 3rd. Injection technique to induce penile erection. Urology 1974;4(4):473–4. DOI: 10.1016/0090-4295(74)90025-9.

11. Wolffenbuttel K.P., Wondergem N., Hoefnagels J.J. et al. Abnormal urine flow in boys with distal hypospadias before and after correction. J Urol 2006;176(4 Pt 2):1733–6; discussion 1736–7. DOI: 10.1016/S0022-5347(06)00614-8.

12. Rynja S.P., de Jong T.P., Bosch J.L., de Kort L.M. Functional, cosmetic and psychosexual results in adult men who underwent hypospadias correction in childhood. J Pediatr Urol 2011;7(5): 504–15. DOI: 10.1016/j.jpurol.2011.02.008.

13. Nuininga J.E., De Gier R.P., Verschuren R., Feitz W.F. Long-term outcome of different types of 1-stage hypospadias repair. J Urol 2005;174(4 Pt 2):1544–8; discussion 1548. DOI: 10.1097/01.ju.0000179255.55848.50.

14. Myers J.B., McAninch J.W., Erickson B.A., Breyer B.N. Treatment of adults with complications from previous hypospadias surgery. J Urol 2012;188(2):459–63. DOI: 10.1016/j.juro.2012.04.007.

15. Mattioli G., Repetto P., Carlini C. et al. Lichen sclerosus et atrophicus in children with phimosis and hypospadias. Pediatr Surg Int 2002;18(4):273–5. DOI: 10.1007/s003830100699.

16. Rourke K., Braga L.H. Transitioning patients with hypospadias and other penile abnormalities to adulthood: What to expect? Can Urol Assoc J 2018;12 (4 Suppl 1):S27–33. DOI: 10.5489/cuaj.5227.

17. Schneuer F.J., Holland A.J.A., Pereira G. et al. Prevalence, repairs and complications of hypospadias: an Australian population-based study. Arch Dis Child 2015;100(11):1038–43. DOI: 10.1136/archdischild-2015-308809.

18. Badawy H., Soliman A., Moussa A. et al. Staged repair of redo and crippled hypospadias: analysis of outcomes and complications. J Pediatr Urol 2019;15(2):151.e1–151.e10. DOI: 10.1016/j.jpurol.2019.01.002.

19. Leslie B., Lorenzo A.J., Figueroa V. et al. Critical outcome analysis of staged buccal mucosa graft urethroplasty for prior failed hypospadias repair in children. J Urol 2011;185(3):1077–82. DOI: 10.1016/j.juro.2010.10.047.

20. Pandey A., Barta-Kelemen A.M., Borisenkov M., Keller H. The staged urethroplasty with vascularised scrotal flap and buccal mucosa graft after failed hypospadias surgery: a reliable technique with a Novel Tool. Urol Int 2017;99(1): 36–42. DOI: 10.1159/000464107.

21. Gill N.A., Hameed A. Management of hypospadias cripples with two-staged Bracka’s technique. J Plast Reconstr Aesthet Surg 2011;64(1):91–6. DOI: 10.1016/j.bjps.2010.02.033.

22. Djordjevic M.L. Graft surgery in extensive urethral stricture disease. Curr Urol Rep 2014;15(8):424. DOI: 10.1007/s11934-014-0424-3.

23. Fasolis M., Zavattero, E., Sedigh O. et al. Oral mucosa harvest for urologic reconstruction: role of maxillofacial surgeon and donor-site morbidity evaluation. J Craniofac Surg 2014;25(2):604–6. DOI: 10.1097/SCS.0000000000000687.

24. Bracka A. The role of two-stage repair in modern hypospadiology. Indian J Urol 2008;24(2):210–8. DOI: 10.4103/0970-1591.40618.

25. Bracka A. A versatile two-stage hypospadias repair. Br J Plast Surg 1995;48(6):345–52. DOI: 10.1016/s0007-1226(95)90023-3.

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