Андрология и генитальная хирургия. 2019; 20: 78-85
Клинический случай преодоления бесплодия, обусловленного мужским фактором (глобозооспермией 1‑го типа), методом интрацитоплазматической инъекции морфологически нормального сперматозоида с активацией ооцитов Ca2+-ионофором
https://doi.org/10.17650/2070-9781-2019-20-3-78-85Аннотация
Представлен случай лечения супружеского бесплодия, вызванного мужским фактором – тяжелой формой тератозооспермии (тотальной глобозооспермией 1‑го типа). Данная патология встречается крайне редко (у 0,1 % пациентов с андрологическими заболеваниями). Глобозооспермия 1‑го типа – недостаточно изученное тяжелое нарушение сперматогенеза, которое приводит к абсолютному мужскому бесплодию. В описанном клиническом случае для лечения были использованы вспомогательные репродуктивные технологии, а именно метод интрацитоплазматической инъекции морфологически нормального сперматозоида с активацией ооцитов Ca2+-ионофором А23187. Наступившая беременность и последующие роды протекали благоприятно.
Список литературы
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Andrology and Genital Surgery. 2019; 20: 78-85
The clinical case of infertility treatment caused by male factor (globozoospermia type 1) by the intracytoplasmic morphologically normal sperm injection with activation of the oocytes by Ca2+-ionophore
https://doi.org/10.17650/2070-9781-2019-20-3-78-85Abstract
A case of infertility treatment in couple with a male factor, the severe form of teratozoospermia (total globozoospermia (type 1)) was presented. This pathology is extremely rare (0.1 % at andrological patients). Globozoospermia (type 1) is an insufficiently studied disease and is a severe disorder of spermatogenesis that leads to 100 % of male infertility. Assisted reproductive technologies with using of intracytoplasmic morphologically normal sperm injection and the activation of oocytes – by Ca2+-ionophore A23187 in a man with globozoospermia (type 1) helped in the treatment of infertility in matrimony. Pregnancy and childbirth proceeded favorably.
References
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2. Thonneau P., Marchand S., Tallec A. et al. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988–1989). Hum Reprod 1991;6(6):811–6. DOI: 10.1093/oxfordjournals.humrep.a137433.
3. WHO Manual for the standardized investigation and diagnosis of the infertile couple. Available at: https://www.who.int/reproductivehealth/publications/infertility/9780521431361/en
4. Andrology: male reproductive health and dysfunction. Ed. by E. Nieschlag, H.M. Behre, S. Nieschlag. 3rd edn. Berlin; Heidelberg: Springer-Verlag, 2010. Pp. 83–87.
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6. Johnson M.D. Genetic risks of intracytoplasmic sperm injection in the treatment of male infertility: recommendations for genetic counseling and screening. Fertil Steril 1998;70(3):397–411. DOI: 10.1016/s0015-0282(98)00209-x.
7. WHO manual for the standardized investigation and diagnosis of the infertile male. Cambridge: Cambridge University Press, 2000. 102 p.
8. Anton-Lamprecht I., Kotzur B., Schopf E. Roundheaded human spermatozoa. Fertil Steril 1976;27(6):685–93. DOI: 10.1016/s0015-0282(16)41900-x.
9. Chansel-Debordeaux I., Dandien S., Bechoua S., Jimenez C. Reproduction outcome in globozoospermie men update and prospects. Andrology 2015;3(6):1022–34.
10. Koscinski I., Elinati E., Fossard C. et al. DPY19L2 deletion as a major cause of globozoospermia. Am J Hum Genet 2011;88(3):344–50. DOI: 10.1016/j.ajhg.2011.01.018.
11. Lundin K., Sjögren A., Nilsson L., Hamberger L. Fertilization and pregnancy after intracytoplasmic microinjection of acrosomeless spermatozoa. Fertil Steril 1994;62(6):1266–7. DOI: 10.1016/0020-7292(96)88705-4.
12. Tejera A., Mollá M., Muriel L. et al. Successful pregnancy and childbirth after intracytoplasmic sperm injection with calcium ionophore oocyte activation in a globozoospermic patient. Fertil Steril 2008;90(4):1202.e1–5. DOI: 10.1016/j.fertnstert.2007.11.056.
13. Egashira A., Murakami M., Haigo K. et al. A successful pregnancy and live birth after intracytoplasmic sperm injection with globozoospermic sperm and electrical oocyte activation. Fertil Steril 2009;92(6):2037.e5–9. DOI: 10.1016/j.fertnstert.2009.08.013.
14. WHO laboratory manual for the examination and processing of human semen. 5th edn. WHO Press, 2010. 394 p.
