Андрология и генитальная хирургия. 2017; 18: 33-38
ФОРМЫ ПАТОЗООСПЕРМИИ У МУЖЧИН С БЕСПЛОДИЕМ В БРАКЕ И/ИЛИ С НАРУШЕНИЯМИ РЕПРОДУКТИВНОЙ СИСТЕМЫ
https://doi.org/10.17650/2070-9781-2017-18-2-33-38Аннотация
В работе представлены результаты исследования 755 образцов эякулята мужчин, обратившихся в ФГБНУ «МГНЦ» в связи с бесплодием в браке и/или нарушениями репродуктивной системы. Для всех образцов выполняли стандартное спермиологическое исследование (ВОЗ, 2010, 5 изд.). Нормозооспермия определена в 11 % случаев, в 89 % образцов эякулята выявлена патозооспермия. Некрозооспермия выявлена в 1 % исследованных образцов. Олигоспермия (сниженный объем эякулята) выявлена в 12 % образцов, при этом в 98 % случаев патология сочеталась с другими нарушениями (снижение концентрации, морфологически нормальных форм или подвижности сперматозоидов). Наиболее распространенными формами патозооспермии являлись астенозооспермия (41 %), астенотератозооспермия (26 %) и олигоастенотератозооспермия (15 %). Частота встречаемости азоои криптозооспермии суммарно составила 4 %. Другие формы патозооспермии (тератозооспермия, олигозооспермия, олиготератозооспермия) в сумме составили 3 %. Выявлено, что доля морфологически нормальных форм положительно коррелирует с долей прогрессивно подвижных гамет, общей подвижностью сперматозоидов, концентрацией, а также общим количеством сперматозоидов в эякуляте.
Список литературы
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Andrology and Genital Surgery. 2017; 18: 33-38
TYPES OF PATHOZOOSPERMIA IN MEN WITH INFERTILITY IN MARRIAGE АND/OR DISORDERS OF REPRODUCTIVE SYSTEM
https://doi.org/10.17650/2070-9781-2017-18-2-33-38Abstract
We analyzed 755 semen samples from men with infertility in marriage and/or disorders of reproductive system. Standard semen analysis (WHO, 2010) was performed for all the samples. Only 11 % of the samples were normozoospermic. Various types of semen pathology were found in 89 % of the investigated samples. Necrozoospermia was detected in 1 % of the samples. Oligospermia was revealed in 12 % of the samples, in 98 % cases it was accompanied by pathozoospermia (abnormal morphology, low sperm concentration or motility). The most common types of pathozoospermia were asthenozoospermia (41 % of all studied samples), asthenoteratozoospermia (26 %) and oligoasthenoteratozoospermia (15 %). Azoospermia and cryptozoospermia were totally observed in 4 % of the samples. 3 % of the samples were defined as other types of pathozoospermia (teratozoospermia, oligozoospermia etc.). Positive correlations between the percentage of morphologically normal spermatozoa and the percentage of motile, percentage of progressively motile spermatozoa, concentration and total number of spermatozoa were found.
References
1. Nieschlag E., Behre H.M., Nieschlag S. (eds.) Andrology: male reproductive health and dysfunction. 3rd edn. SpringerVerlag Berlin Heidelberg, 2010. 629 r.
2. WHO laboratory manual for the examination and processing of human semen. 5th edn. 271 r.
3. Haidl G. New WHO-reference limitsrevolution or storm in a teapot? Asian J Androl 2011;13(2):208–11. DOI: 10.1038/aja.2010.156.
4. Murray K.S., James A., McGeady J.B. et al. The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility. Fertil Steril 2012;98(6):1428–31.
5. Esteves S.C. Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination. Int Braz J Urol 2014;40(4):443–53. DOI: 10.1590/S1677-5538.IBJU.2014.04.02.
6. Esteves S.C., Agarwai A. The azoospermic male: current knowledge and future perspectives. Clinics (Sao Paulo)m2013;68(Suppl 1):1–4. PMID: 23503949.
7. Chemes H.E., Rawe Y.V. Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men. Human Reproduction Update 2003;9(5):405–28. PMID: 14640375.
8. Correa-Perez J.R., Fernández-Pelegrina R., Aslanis P., Zavos P.M. Clinical management of men producing ejaculates characterized by high levels of dead sperm and altered seminal plasma factors consistent with epididymal necrospermia. Fertility and Sterility 2004;81(4):1148–50. DOI: 10.1016/j.fertnstert.2003.09.047. PMID: 15066482.
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23. WHO Laboratory Manual for the Examination of Human Semen and Spermcervical Mucus Interaction. 4th edn. Cambridge: Cambridge University Press, 1999. 128 p.
