Андрология и генитальная хирургия. 2016; 17: 23-27
Показатели ингибина В в сыворотке крови у инфертильных больных
https://doi.org/10.17650/2070-9781-2016-17-1-23-27Аннотация
Повышенный интерес к ингибину В, который вырабатывают клетки Сертоли, обусловлен тем, что на основании полученных данных некоторые авторы зафиксировали взаимосвязь уровня этого гормона с бесплодием. В статье представлены результаты исследования мужских половых гормонов (ингибин В, фолликулостимулирующий и антимюллеровский гормоны) в сыворотке крови пациентов с азооспермией (1-я группа), у которых по результатам биопсии выявлен сперматогенез, без сперматогенеза (2-я группа) и с олигоастенозооспермией (3-я группа). По результатам исследования в 1-й группе отметили нормальный уровень ингибина В, во 2-й – пониженный более чем в 2 раза. Кроме того, у больных 2-й группы зафиксирован повышенный уровень фолликулостимулирующего и низкий уровень антимюллеровского гормонов по сравнению с 1-й группой.
Список литературы
1. European Association of Urology. Guidelines. 2010; 2012; 2014.
2. Baker K., Sabanegh Jr. E. Obstructive azoospermia: reconstructive techniques and results. Clinics (Sao Paulo) 2013; 68(Suppl 1):61–73.
3. Wosnitzer M., Goldstein M., Hardy M. P. Review of Azoospermia. Spermatogenesis 2014;4:e28218.
4. Chong Y. H., Pankhurst M. W., McLennan I. S. The Daily Profiles of Circulating AMH and INSL3 in Men are Distinct from the Other Testicular Hormones, Inhibin B and Testosterone. PLoS One 2015;10(7):e0133637.
5. Krause W., Bohring C. Inhibin B as a marker of spermatogenesis. A new dimension in andrology. Hautarzt 2002; 53(1):5–10.
6. Anawalt B. D., Bebb R. A., Matsumoto A. M. et al. Serum inhibin level reflect Sertoli’s cells function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab 1996;81(9):3341–5.
7. Bouvattier C., Esterle L., Renoult-Pierre P. et al. Clinical Outcome, Hormonal Status, Gonadotrope Axis, and Testicular Function in 219 Adult Men Born With Classic 21-Hydroxylase Deficiency. A French National Survey. J Clin Endocrinol Metab 2015;100(6):2303–13.
8. Braga L. H., Lorenzo A. J. The changing elaboration of inhibin B in patients with unilateral testicular maldescent vs vanished testis. J Urol 2015;193(5):1465–6.
9. Calogero A. E., Gullo G., La Vignera S. et al. Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology 2015;3(3):491–5.
10. Anderson A. M., Muller J., Skakkebaek N. E. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 1998;83(12):4451–8.
11. Manzoor S. M., Sattar A., Hashim R. et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012;24(3–4):113–6.
12. Datta A., Nayini K., Eapen A. et al. Serum inhibin-B may predict successful sperm retrieval in azoospermic men with normal gonadotropin and testosterone levels. Hum Reprod 2012;27(Suppl 2).
13. Huang X., Bai Q., Yan L. Y. et al. Combination of serum inhibin B and folliclestimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese nonobstructive azoospermic men. Chin Med J 2012;125(16):2885–9.
14. Blevrakis E., Chatzidarellis E., Anyfantakis D. et al. Impact of varicocele on biological markers of gonadal function. Hernia 2015.
15. Grunewald S., Glander H. J., Paasch U., Kratzsch J. Age-dependent inhibin B concentration in relation to FSH and semen sample qualities: A study in 2448 men. Reproduction 2013;145(3):237–44.
16. Ruiz Plazas X., Burgues Gasion J. P., Ozonas Moragues M., Piza Reus P. Utility of inhibin B in the management of male infertility. Actas Urol Esp 2010;34(9): 781–7.
Andrology and Genital Surgery. 2016; 17: 23-27
Serum inhibin B values in infertile patients
https://doi.org/10.17650/2070-9781-2016-17-1-23-27Abstract
The increased interest in inhibin B generated by Sertoli cells is due to the fact that on the basis of findings, some authors recorded a relationship between the level of this hormone and infertility. The paper gives the results of an investigation of male sex hormones (inhibin B, follicle-stimulating and anti-Müllerian hormones) in the serum of patients with azoospermia (Group 1), who had spermatogenesis, as evidenced by testicular biopsy, who had no spermatogenesis (Group 2), and who had oligoasthenozoospermia (Group 3). The investigation indicated that Group 1 had a normal inhibin B level that was more than twice lower in Group 2. In addition, the latter group was recorded to have elevated follicle-stimulating hormone levels and low anti-Müllerian hormone concentrations as compared to Group 1.
References
1. European Association of Urology. Guidelines. 2010; 2012; 2014.
2. Baker K., Sabanegh Jr. E. Obstructive azoospermia: reconstructive techniques and results. Clinics (Sao Paulo) 2013; 68(Suppl 1):61–73.
3. Wosnitzer M., Goldstein M., Hardy M. P. Review of Azoospermia. Spermatogenesis 2014;4:e28218.
4. Chong Y. H., Pankhurst M. W., McLennan I. S. The Daily Profiles of Circulating AMH and INSL3 in Men are Distinct from the Other Testicular Hormones, Inhibin B and Testosterone. PLoS One 2015;10(7):e0133637.
5. Krause W., Bohring C. Inhibin B as a marker of spermatogenesis. A new dimension in andrology. Hautarzt 2002; 53(1):5–10.
6. Anawalt B. D., Bebb R. A., Matsumoto A. M. et al. Serum inhibin level reflect Sertoli’s cells function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab 1996;81(9):3341–5.
7. Bouvattier C., Esterle L., Renoult-Pierre P. et al. Clinical Outcome, Hormonal Status, Gonadotrope Axis, and Testicular Function in 219 Adult Men Born With Classic 21-Hydroxylase Deficiency. A French National Survey. J Clin Endocrinol Metab 2015;100(6):2303–13.
8. Braga L. H., Lorenzo A. J. The changing elaboration of inhibin B in patients with unilateral testicular maldescent vs vanished testis. J Urol 2015;193(5):1465–6.
9. Calogero A. E., Gullo G., La Vignera S. et al. Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology 2015;3(3):491–5.
10. Anderson A. M., Muller J., Skakkebaek N. E. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 1998;83(12):4451–8.
11. Manzoor S. M., Sattar A., Hashim R. et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012;24(3–4):113–6.
12. Datta A., Nayini K., Eapen A. et al. Serum inhibin-B may predict successful sperm retrieval in azoospermic men with normal gonadotropin and testosterone levels. Hum Reprod 2012;27(Suppl 2).
13. Huang X., Bai Q., Yan L. Y. et al. Combination of serum inhibin B and folliclestimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese nonobstructive azoospermic men. Chin Med J 2012;125(16):2885–9.
14. Blevrakis E., Chatzidarellis E., Anyfantakis D. et al. Impact of varicocele on biological markers of gonadal function. Hernia 2015.
15. Grunewald S., Glander H. J., Paasch U., Kratzsch J. Age-dependent inhibin B concentration in relation to FSH and semen sample qualities: A study in 2448 men. Reproduction 2013;145(3):237–44.
16. Ruiz Plazas X., Burgues Gasion J. P., Ozonas Moragues M., Piza Reus P. Utility of inhibin B in the management of male infertility. Actas Urol Esp 2010;34(9): 781–7.
