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Андрология и генитальная хирургия. 2015; 16: 46-50

Сравнительный анализ гистологических данных до и после радикальной простатэктомии у больных с низким дооперационным онкологическим риском

Аляев Ю. Г., Варшавский В. А., Рапопорт Л. М., Цариченко Д. Г., Еникеев М. Э., Королев Д. О., Фокин И. В.

https://doi.org/10.17650/2070-9781-2015-16-4-46-50

Аннотация

Рак предстательной железы (РПЖ) считается сегодня одной из самых серьезных медицинских проблем среди мужского населения. В настоящее время РПЖ занимает 2-е место среди онкологических заболеваний по смертности у мужчин. Гистологическая градация является важным прогностическим фактором в лечении РПЖ. Оценка аденокарциномы предстательной железы по шкале Глисона служит самым надежным прогностическим фактором клинического поведения опухоли и ее ответа на лечение. Выбор оптимального лечения больных РПЖ намного усложнился в связи с тем, что разные методы имеют равные онкологические результаты, но различаются по своим осложнениям. С прогностической точки зрения существует значительный интерес, насколько гистологические результаты биопсии предстательной железы (сумма баллов по шкале Глисона) соответствуют таковым после радикальной простатэктомии. В настоящей статье мы приводим сравнительный анализ гистологических данных до и после радикальной простатэктомии у больных с низким дооперационным онкологическим риском.
Список литературы

1. Quinn M., Babb P. Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int 2002;90(2):162–73.

2. Ries L.A.G., Kosary C.L., Hankey B.F. et al. SEER Cancer Statistics Review 1973–1995. Bethesda, MD: National Cancer Institute, 1998.

3. Чиссов В.И., Русаков И.Г. Заболеваемость раком предстательной железы в Российской Федерации. Экспериментальная и клиническая урология 2011; (2–3):6–7. [Chissov V.I., Rusakov I.G. Prostate cancer rate in the Russian Federation. Eksperimental,naya i klinicheskaya urologiya = Experimental and Clinical Urology 2011;(2–3):6–7. (In Russ.)].

4. Parkin D.M., Pisani P., Ferlay J. Estimates of worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993;54(4):594–606.

5. Catalona W.J., Richie J.P., Ahmann F.R. et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of multicenter clinical trial of 6630 men. J Urol 1994;151(5): 1283–90.

6. Billis A., Guimaraes M.S., Freitas L.L. et al. The impact of the 2005 International Society of Urological Pathology consensus conference on standard Gleason grading of prostatic carcinoma in needle biopsies. J Urol 2008;180 (2):548–52.

7. Bill-Axelson A., Holmberg L., Filen F. et al. Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group – 4 randomized trial. J Natl Cancer Inst 2008;100(16):1144–54.

8. Tewari A., Johnson C.C., Divine G. et al. Long-term survival probability in men with clinically localized prostate cancer: a casecontrol, propensity modeling study stratified by race, age, treatment and comorbidities. J Urol 2004;171(4):1513–9.

9. Djavan B., Kadesky K., Klopukh B. et al. Gleason scores from prostate biopsies obtained with 18-gauge biopsy needles poorly predict Gleason scores of radical prostatectomy specimens. Eur Urol 1998;33(3):261–70.

10. Gleason D. Classification of prostate carcinomas. Cancer Chemother Rep 1966;50(3):125–28.

11. Baillar J., Mellinger G., Gleason D. Survival rates of patients with prostatic cancer, tumor stage and differentiation. Cancer Chemother Rep 1966;50:129–36.

12. Gleason D.F., Mellinger G.T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974;111(1):58–64.

13. Gleason D.F. Histological grading and clinical staging of prostatic carcinoma. In: Urologic pathology: The prostate. Philadelphia, 1977. Pp. 171–97.

Andrology and Genital Surgery. 2015; 16: 46-50

Сomparative analysis of the histologic data before and after radical prostatectomy patients with low pre-operative cancer risk

Alyaev Yu. G., Varshavskiy V. A., Rapoport L. M., Tsarichenko D. G., Еnikeev M. E., Korolev D. O., Fokin I. V.

https://doi.org/10.17650/2070-9781-2015-16-4-46-50

Abstract

Prostate cancer (PC) is the most frequent cancer among men in the world. At current PC takes 2nd place in men mortality among all oncological diseases. Histological grading is an important part of the diagnostic evaluation. The most commonly used grading system is the one described by Gleason. The choice of optimal PC treatment becomes complicated due to the fact that different methods have the same oncological results but differ in their complications. From a prognostic point of view, it is of considerable interest to know how accurate the needle biopsy Gleason score is in predicting the final score of the radical prostatectomy specimen. This paper describes comparative analysis of the histologic data before and after radical prostatectomy patients with low pre-operative cancer risk.
References

1. Quinn M., Babb P. Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int 2002;90(2):162–73.

2. Ries L.A.G., Kosary C.L., Hankey B.F. et al. SEER Cancer Statistics Review 1973–1995. Bethesda, MD: National Cancer Institute, 1998.

3. Chissov V.I., Rusakov I.G. Zabolevaemost' rakom predstatel'noi zhelezy v Rossiiskoi Federatsii. Eksperimental'naya i klinicheskaya urologiya 2011; (2–3):6–7. [Chissov V.I., Rusakov I.G. Prostate cancer rate in the Russian Federation. Eksperimental,naya i klinicheskaya urologiya = Experimental and Clinical Urology 2011;(2–3):6–7. (In Russ.)].

4. Parkin D.M., Pisani P., Ferlay J. Estimates of worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993;54(4):594–606.

5. Catalona W.J., Richie J.P., Ahmann F.R. et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of multicenter clinical trial of 6630 men. J Urol 1994;151(5): 1283–90.

6. Billis A., Guimaraes M.S., Freitas L.L. et al. The impact of the 2005 International Society of Urological Pathology consensus conference on standard Gleason grading of prostatic carcinoma in needle biopsies. J Urol 2008;180 (2):548–52.

7. Bill-Axelson A., Holmberg L., Filen F. et al. Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group – 4 randomized trial. J Natl Cancer Inst 2008;100(16):1144–54.

8. Tewari A., Johnson C.C., Divine G. et al. Long-term survival probability in men with clinically localized prostate cancer: a casecontrol, propensity modeling study stratified by race, age, treatment and comorbidities. J Urol 2004;171(4):1513–9.

9. Djavan B., Kadesky K., Klopukh B. et al. Gleason scores from prostate biopsies obtained with 18-gauge biopsy needles poorly predict Gleason scores of radical prostatectomy specimens. Eur Urol 1998;33(3):261–70.

10. Gleason D. Classification of prostate carcinomas. Cancer Chemother Rep 1966;50(3):125–28.

11. Baillar J., Mellinger G., Gleason D. Survival rates of patients with prostatic cancer, tumor stage and differentiation. Cancer Chemother Rep 1966;50:129–36.

12. Gleason D.F., Mellinger G.T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974;111(1):58–64.

13. Gleason D.F. Histological grading and clinical staging of prostatic carcinoma. In: Urologic pathology: The prostate. Philadelphia, 1977. Pp. 171–97.