Андрология и генитальная хирургия. 2015; 16: 18-26
Хронический простатит категории IIIВ/синдром хронической тазовой боли и сексуальные дисфункции
https://doi.org/10.17650/2070-9781-2015-16-4-18-26Аннотация
Представлен обзор литературы по актуальной проблеме урологии – хроническому абактериальному простатиту (ХАП) категории IIIВ/синдрому хронической тазовой боли (СХТБ) и сексуальной дисфункции при данной патологии. В настоящее время отсутствуют точные данные относительно этиологии и патогенеза как ХАП/СХТБ, так и сексуальной дисфункции при данном заболевании. Несмотря на значительное количество опубликованных работ, данное патологическое состояние остается недостаточно изученным и плохо поддающимся лечению.
Наиболее вероятно, что за диагнозом ХАП/СХТБ скрывается целая гамма различных состояний, в том числе таких, когда предстательная железа вовлечена в патологический процесс лишь косвенно или не вовлечена вовсе. Некоторые факторы, такие как нейропатия пудендального нерва с развитием хронического простатита, СХТБ, везикулообструкции, нейровегетативные расстройства, могут носить одновременно этиологический и патогенетический характер.
Проблема терапии ХАП остается нерешенной до настоящего времени, несмотря на многообразие применяемых методов лечения. Как правило, терапевтические подходы направлены лишь на улучшение качества жизни больного. Все существующие методы лечения хронического простатита подразумевают в качестве желаемого результата и снижение уровня сексуальной дисфункции. Надежды на улучшение результатов лечения связаны с прогрессом в области диагностики и дифференциальной диагностики этих состояний, совершенствованием и детализацией клинической классификации заболевания, накоплением достоверных клинических результатов, характеризующих эффективность и безопасность лекарственных средств в четко очерченных группах пациентов.
Список литературы
1. Gujadhur R., Aning J. Careful assessment key in managing prostatitis. Practitioner 2015;259(1781):15–9.
2. Krieger J.N., Nyberg L. Jr, Nickel J.C. NIH consensus definition and classification of prostatitis. JAMA 1999;282(3):236–7.
3. Abrams P., Cardozo L., Fall M. et al. The standartisation of terminology of lower urinary tract function: report from the Standartisation Sub-committee of the International Continence Society. Am J Obstet Gynecol 2002;187(1):116–26.
4. Гундорова Л.В. Новое в лечении хронического простатита. Русский медицинский журнал 2003;11(6):37. [Gundorova L.V. New aspects of the treatment of chronic prostatitis. Russkiy meditsinskiy zhurnal = Russian Medical Journal 2003;11(6):37. (In Russ.)].
5. Сивков А.В., Толстова С.С., Егоров А.А., Ромих В.В. Роль комбинированного уродинамического исследования в диагностике нарушений мочеиспускания у пациентов с хроническим простатитом моложе 50 лет. В сб.: Современные принципы диагностики и лечения хронического простатита. Курск, 2000. С. 145–6. [Sivkov А.V., Тоlstovа S.S., Еgorov А.А., Romikh V.V. Role of the combined urodynamic examination for the diagnostics of urination at patients with chronic prostatitis younger than 50 y. o. In: Modern principles of the diagnostics and treatment of chronic prostatitis. Kursk, 2000. Pp. 145–6. (In Russ.)].
6. Мазо Е.Б., Касаткина Л.Ф., Школьников М.Е., Горчханов М.А. Синдром хронической боли или хронический простатит: взгляд с точки зрения игольчатой электромиографии мышц тазового дна. Урология 2006;(1):43–7. 6. [Маzо Е.B., Kasatkina L.F., Shkol'nikov М.Е.,
7. Gorchkhanov М.А. Сhronic pain syndrome or chronic prostatitis: from the point of view of the intramuscular electromyography of pelvic muscles. Urologiya = Urology 2006;(1):43–7. (In Russ.)].
8. Chung B.H., Hong S.J. Long-term followup study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension. BJU Int 2006;97(1):90–5.
9. Коган М.И., Белоусов И.И., Болоцков А.С. Артериальный кровоток в простате при синдроме хронической тазовой боли/хроническом простатите. Урология 2011;(3):22–4. 8. [Kogan М.I., Belousov I.I., Bolotskov А.S. Arterial blood flow in the prostate at the chronic pelvic pain syndrome/chronic prostatitis. Urologiya = Urology 2011;(3):22–4. (In Russ.)].
10. Сивков А.В., Егоров А.А., Ромих В.В. Псевдодиссинергия и синдром хронической тазовой боли у больных хроническим абактериальным простатитом. В сб.: Тезисы пленума правления Российского общества урологов. Саратов, 2004. С. 260–1. [Sivkov А.V., Еgorov А.А., Romikh V.V. Pseudodissinergy and chronic pelvic pain syndrome at patients with chronic abacterial prostatitis. In: Proceedings of the board plenum of the Russian Urologists’ Society. Saratov, 2004. Pp. 260–1. (In Russ.)].
11. Osborn D.E., George N.J., Rao P.N. et al. Prostatodynia – physiological characteristics and rational management with muscle relaxants. Br J Urol 1981;53(6):621–3.
12. Коган М.И., Белоусов И.И., Шорников П.В. Нейрофизиологическая оценка пациентов с хроническим простатитом (синдром хронической тазовой боли IIIБ). Урология 2012;(4):37–43. [Kogan М.I., Belousov I.I., Shornikov P.V. Neurophysiological evaluation of patients with chronic prostatitis (chronic pelvic pain syndrome IIIB). Urologiya = Urology 2012;(4):37–43. (In Russ.)].
13. Zhang Z., Liang C.Z., Zhang X.S. et al. Impact of BKCa channel in prostate smooth muscle cells on the membrane potential in rats with chronic abacterial prostatitis. Zhonghua Nan Ke Xue 2013;19(1):10–4.
14. Егоров А.А. Нарушение уродинамики нижних мочевых путей и функции тазового дна у больных хроническим абактериальным простатитом. Автореф. дис. … канд. мед. наук. М., 2007. [Еgorov А.А. Urodynamical dysfunction of lower urinary tracts and pelvic functions at patients with chronic abacterial prostatitis: Author,s abstract of thesis … of candidate of medical sciences. Moscow, 2007. (In Russ.)].
15. Davis S.N., Morin M., Binik Y.M. et al. Use of pelvic floor ultrasound to assess pelvic floor muscle function in urological chronic pelvic pain syndrome in men. J Sex Med 2011;8(11):3173–80.
16. Извозчиков С.Б. Невоспалительный синдром хронической тазовой боли у мужчин: неврологические аспекты урологической проблемы. Дис. … канд. мед. наук. М., 2007. [Izvozchikov S.B. Neurous inflammatory syndrome of the chronic pelvic pain at men: neurologic aspects of the urologic problem. Thesis … of candidate of medical sciences. Мoscow, 2007. (In Russ.)].
17. Извозчиков С.Б. «Тазовая боль напряжения»: взгляд невролога на проблему простатодинии. Урология 2010;(3):68–70. [Izvozchikov S.B. “Pelvic pain strain”: neurologist,s vision of the prostalgia problem. Urologiya = Urology 2010;(3): 68–70. (In Russ.)].
18. Berger R.E., Ciol M.A., Rothman I., Turner J.A. Pelvic tenderness is not limited to the prostate in chronic prostatitis/chronic pelvic pain syndrome (CPPS) type IIIA and IIIB: comparison of men with and without CP/CPPS. BMC Urol 2007;7:17.
19. Извозчиков С.Б., Селицкий Г.В., Камчатнов П.Р. Синдром хронической тазовой боли. Журнал неврологии и психиатрии им. С.С. Корсакова 2011;111(5):71–4. [Izvozchikov S.B., Selitskiy G.V., Kamchatnov P.R. Chronic pelvic pain syndrome. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2011;111(5):71–4. (In Russ.)].
20. Schover L.R. Psychological factors in men with genital pain. Cleve Clin J Med 1990;57(8):697–700.
21. Pierce A.N., Christianson J.A. Stress and chronic pelvic pain. Prog Mol Biol Transl Sci 2015;131:509–35.
22. Berberich H.J., Ludwig M. Psychosomatische aspekte des chronischen beckenschmerzes. Urologe A 2004;43(3):254–60.
23. Кузнецкий Ю.Я. Хронический простатит/синдром хронической тазовой боли как психосоматическое заболевание и его рациональная терапия. Омский научный вестник 2006;(6):215–21. [Kuznetskiy Yu.Ya. Chronic prostatitis/ chronic pelvic pain syndrome as psychosomatic diseases and its rational therapy. Omskiy nauchnyy vestnik = Omsk Scientific Herald 2006;(6):215–21. (In Russ.)].
24. Михайличенко В.В., Александров В.П. Сексуальное здоровье мужчины, решение деликатной проблемы. СПб.: Невский проспект, 2003. 160 с. [Мikhaylichenko V.V., Аlexandrov V.P. Men, s sexual health, delicate problem solving. Saint Petersburg: Nevskiy Prospekt, 2003. 160 p. (In Russ.)].
25. Вакина Т.Н., Шутов А.М., Шалина С.В. и др. Дегидроэпиандростерон и половая функция у мужчин с хроническим простатитом. Урология 2003;(1):49–51. [Vakina Т.N., Shutov А.М., Shalina S.V. et al. Dehydroepiandrosterone and sexual function at men with chronic prostatitis. Urologiya = Urology 2003;(1):49–51. (In Russ.)].
26. Gonen M., Kalkan M., Cenker A., Ozkardes H. Prevalence of premature ejaculation in Turkish men with chronic pelvic pain syndrome. J Androl 2005;26(5):601–3.
27. Aubin S., Berger R.E., Heiman J.R., Ciol M.A. The association between sexual function, pain, and psychological adaptation of men diagnosed with chronic pelvic pain syndrome type III. J Sex Med 2008;5(3):657–67.
28. Кочарян Г.С. Сексуальные дисфункции у больных хроническим простатитом: модели формирования. Здоровье мужчины 2012;(2):114–22. [Kocharyan G.S. Sexual dysfunctions at patients with chronic prostatitis: formation models. Zdorov,e muzhchiny = Men,s Health 2012;(2): 114–22. (In Russ.)].
29. Althof S.E., McMahon C.G., Waldinger M.D. et al. An update of the International Society of Sexual Medicine,s guidelines for the diagnosis and treatment of premature ejaculation (PE). J Sex Med 2014;11(6):1392–422.
30. Seyam R. A systematic review of the correlates and management of nonpremature ejaculatory dysfunction in heterosexual men. Ther Adv Urol 2013;5(5):254–97.
31. Chen X., Zhou Z.R., Qiu X.C. et al. The effect of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on Erectile function: a systematic review and metaanalysis. PLoS One 2015;10(10):1–13.
32. Tran C.N., Shoskes D.A. Sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. World J Urol 2013;31(4):741–6.
33. Riegel B., Bruenahl C.A., Ahyai S. et al. Assessing psychological factors, social aspects and psychiatric co-morbidity associated with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men – a systematic review. J Psychosom Res 2014;77(5): 333–50.
34. Mo M.Q., Long L.L., Xie W.L. et al. Sexual dysfunctions and psychological disorders associated with type IIIa chronic prostatitis: a clinical survey in China. Int Urol Nephrol 2014;46(12):2255–61.
35. Гаврилов В.Е. Синдром невоспалительной хронической тазовой боли у мужчин – особенности клиники, диагностика и лечение. Дис. … канд. мед. наук. М., 2005. [Gavrilov V.Е. Syndrome of the non-inflammatory chronic pelvic pain at men – clinical peculiarities, diagnosis and treatment. Thesis … of candidate of medical sciences. Moscow, 2005. (In Russ.)].
36. Лопаткин H.A., Пугачев А.Г., Аполихин О.И. Урология. Под ред. Н.А. Лопаткина. 5-е изд., перераб. и доп. М.: ГЭОТАР-МЕД, 2002. [Lopatkin N.A., Pugachev А.G., Аpolikhin О.I. Urology. Ed. N.А. Lopatkin. 5th ed., revised and enlarged. Moscow: GEOTAR-МЕD, 2002. (In Russ.)].
37. Сивков A.B., Ощепков В.Н., Егоров A.A. Терапия хронического абактериального неинфекционного простатита. В кн.: Современные принципы диагностики и лечения хронического простатита: материалы пленума правления Российского общества урологов. М., 2004. С. 216–30. [Sivkov A.V., Оshchepkov V.N., Еgorov A.A. Тherapy of the chronic abacterial non-infectious prostatitis. In: Modern principles of diagnosis and treatment of the chronic prostatitis: materials of the board plenum of the Russian Urologists, Society. Moscow, 2004. Pp. 216–30. (In Russ.)].
38. Magistro G., Wagenlehner F.M., Grabe M. et al. Contemporary management of chronic prostatitis/chronic pelvic pain syndrome. Eur Urol 2016;69(2): 286–97.
39. Смирнов В.А. Лекарственная терапия хронического простатита. ФАРМиндекс-Практик 2006;(6):46–55. [Smirnov V.А. Pharmaceutical therapy of the chronic prostatitis. FARMindeks-Praktik = PHARMindex-Practic 2006;(6):46–55. (In Russ.)].
40. Мазо Е.Б., Школьников М.Е. Синдром хронической тазовой боли у мужчин (обзор литературы). Consilium Medicum 2008;10(4):15–7. [Маzо Е.B., Shkol,nikov М.Е. Chronic pelvic pain syndrome at men (literature review). Consilium Medicum 2008;10(4):15–7. (In Russ.)].
41. Шаляпин И.В. Значение гемореологических и гемостатических нарушений в патогенезе хронического простатита. Дис. ... канд. мед. наук. Новосибирск, 2001. [Shalyapin I.V. Meaning of hemoreologic dysfunctions and hemostatic diseases in the chronic prostatitis pathogenesis. Thesis … of candidate of medical sciences. Novosibirsk, 2001. (In Russ.)].
42. Schaeffer A.J., Weidner W., Barbalias G.A. Summary consensus statement: diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome. Eur Urol 2003;Suppl 2:1–4.
43. Mishra V.C., Browne J., Emberton M. Role of alpha-blockers in type III prostatitis: a systematic review of the literature. J Urol 2007;177(1):25–30.
44. Шаплыгин Л.В. Применение блокаторов альфа1-адренорецепторов в урологической практике. Военно-медицинский журнал 2007;(7):16–9. [Shaplygin L.V. Application of blockers of alpha1-аdrenoreceptors in the urologic practice. Voenno-meditsinskiy zhurnal = Military Medical Journal 2007;(7):16–9. (In Russ.)].
45. Anderson R.U., Wise D., Sawyer T., Chan C. Integration of myofascial trigger point release and paradoxical relaxation training treatment of chronic pelvic pain in men. J Urol 2005;174(1): 155–60.
46. Переверзев А.С. Хронический тазовый болевой синдром в урологии. Новости медицины и фармации. Урология и нефрология 2008;(258). [Pereverzev А.S. Chronic pelvic pain syndrome in urology. Novosti meditsiny i farmatsii. Urologiya i nefrologiya = News ofMedicine andPharmacy. Urology and Nephrology 2008;(258).(In Russ.)].
47. Вейн А.М., Вознесенская Т.Г., Голубев В.Л., Дюкова Г.М. Депрессия в неврологической практике. М.: МИА, 2007. 208 с. [Veyn А.М., Voznesenskaya Т.G., Golubev V.L., Dukova G.М. Depression in the neurologic practice. Moscow: МIА, 2007. 208 p. (In Russ.)].
48. Селицкий Г.В., Каприн А.Д., Извозчиков С.Б. и др. Милнаципран (иксел) в лечении тревожно-депрессивных и сексуальных расстройств у больных с невоспалительным синдромом хронической тазовой боли. Терапевтический архив 2007;(5):81–4. [Selitskiy G.V., Kaprin А.D., Izvozchikov S.B. et al. Мilnacipran (ixel) in the treatment of anxiety and depressive disorders at patients with noninflammatory syndrome of the chronic pelvic pain. Terapevticheskiy arkhiv = Тherapeutic Archive 2007;(5):81–4. (In Russ.)].
49. Пушкарь Д.Ю., Юдовский С.О., Тевлин К.П. Эректильная дисфункция: современные возможности медикаментозной терапии. Український терапевтичний журнал 2005;(3):84–8. [Pushkar, D.Yu.,
50. Yudovskiy S.О., Теvlin K.P. Erectile dysfunction: modern possibilities of the pharmaceutical therapy. Ukrainskiy terapevtichniy zhurnal = Ukrainian Therapeutic Journal 2005;(3):84–8.(In Ukr.)].
Andrology and Genital Surgery. 2015; 16: 18-26
Category IIIB chronic prostatitis/chronic pelvic pain syndrome and sexual dysfunction
https://doi.org/10.17650/2070-9781-2015-16-4-18-26Abstract
The paper reviews the literature on the topical urological problem category IIIB chronic nonbacterial prostatitis (CNBP)/chronic pelvic pain syndrome (CPPS) and sexual dysfunction in this abnormality. As of now, there is no precise information on the etiology and pathogenesis of CNBP/CPPS and sexual dysfunction in this disease. Despite a considerable body of published work, the disease remains inadequately studied and untreatable.
The diagnosis of CNBP/CPPS is most likely to mask a high range of different conditions, including those when the prostate is only indirectly or by no means involved in the pathological process. Some factors, such as pudendal neuropathy with the development of chronic prostatitis, CPPB, vesical obstruction, and neuroautonomic disorders, may be etiological and pathogenetic simultaneously.
The problem of CNBP therapy remains unsolved so far in spite of a diversity of used treatments. Therapeutic approaches are generally aimed only at improving quality of life in a patient. All existing treatments for chronic prostatitis imply for reducing the level of sexual dysfunction too as a desirable result. Hopes for improving the results of treatment are associated with progress in the diagnosis and differential diagnosis of these conditions, with the improvement and detailed elaboration of clinical classification of the disease, and with the accumulation of the valid clinical results characterizing the efficacy and safety of drugs in well-defined patient groups.
References
1. Gujadhur R., Aning J. Careful assessment key in managing prostatitis. Practitioner 2015;259(1781):15–9.
2. Krieger J.N., Nyberg L. Jr, Nickel J.C. NIH consensus definition and classification of prostatitis. JAMA 1999;282(3):236–7.
3. Abrams P., Cardozo L., Fall M. et al. The standartisation of terminology of lower urinary tract function: report from the Standartisation Sub-committee of the International Continence Society. Am J Obstet Gynecol 2002;187(1):116–26.
4. Gundorova L.V. Novoe v lechenii khronicheskogo prostatita. Russkii meditsinskii zhurnal 2003;11(6):37. [Gundorova L.V. New aspects of the treatment of chronic prostatitis. Russkiy meditsinskiy zhurnal = Russian Medical Journal 2003;11(6):37. (In Russ.)].
5. Sivkov A.V., Tolstova S.S., Egorov A.A., Romikh V.V. Rol' kombinirovannogo urodinamicheskogo issledovaniya v diagnostike narushenii mocheispuskaniya u patsientov s khronicheskim prostatitom molozhe 50 let. V sb.: Sovremennye printsipy diagnostiki i lecheniya khronicheskogo prostatita. Kursk, 2000. S. 145–6. [Sivkov A.V., Tolstova S.S., Egorov A.A., Romikh V.V. Role of the combined urodynamic examination for the diagnostics of urination at patients with chronic prostatitis younger than 50 y. o. In: Modern principles of the diagnostics and treatment of chronic prostatitis. Kursk, 2000. Pp. 145–6. (In Russ.)].
6. Mazo E.B., Kasatkina L.F., Shkol'nikov M.E., Gorchkhanov M.A. Sindrom khronicheskoi boli ili khronicheskii prostatit: vzglyad s tochki zreniya igol'chatoi elektromiografii myshts tazovogo dna. Urologiya 2006;(1):43–7. 6. [Mazo E.B., Kasatkina L.F., Shkol'nikov M.E.,
7. Gorchkhanov M.A. Shronic pain syndrome or chronic prostatitis: from the point of view of the intramuscular electromyography of pelvic muscles. Urologiya = Urology 2006;(1):43–7. (In Russ.)].
8. Chung B.H., Hong S.J. Long-term followup study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension. BJU Int 2006;97(1):90–5.
9. Kogan M.I., Belousov I.I., Bolotskov A.S. Arterial'nyi krovotok v prostate pri sindrome khronicheskoi tazovoi boli/khronicheskom prostatite. Urologiya 2011;(3):22–4. 8. [Kogan M.I., Belousov I.I., Bolotskov A.S. Arterial blood flow in the prostate at the chronic pelvic pain syndrome/chronic prostatitis. Urologiya = Urology 2011;(3):22–4. (In Russ.)].
10. Sivkov A.V., Egorov A.A., Romikh V.V. Psevdodissinergiya i sindrom khronicheskoi tazovoi boli u bol'nykh khronicheskim abakterial'nym prostatitom. V sb.: Tezisy plenuma pravleniya Rossiiskogo obshchestva urologov. Saratov, 2004. S. 260–1. [Sivkov A.V., Egorov A.A., Romikh V.V. Pseudodissinergy and chronic pelvic pain syndrome at patients with chronic abacterial prostatitis. In: Proceedings of the board plenum of the Russian Urologists’ Society. Saratov, 2004. Pp. 260–1. (In Russ.)].
11. Osborn D.E., George N.J., Rao P.N. et al. Prostatodynia – physiological characteristics and rational management with muscle relaxants. Br J Urol 1981;53(6):621–3.
12. Kogan M.I., Belousov I.I., Shornikov P.V. Neirofiziologicheskaya otsenka patsientov s khronicheskim prostatitom (sindrom khronicheskoi tazovoi boli IIIB). Urologiya 2012;(4):37–43. [Kogan M.I., Belousov I.I., Shornikov P.V. Neurophysiological evaluation of patients with chronic prostatitis (chronic pelvic pain syndrome IIIB). Urologiya = Urology 2012;(4):37–43. (In Russ.)].
13. Zhang Z., Liang C.Z., Zhang X.S. et al. Impact of BKCa channel in prostate smooth muscle cells on the membrane potential in rats with chronic abacterial prostatitis. Zhonghua Nan Ke Xue 2013;19(1):10–4.
14. Egorov A.A. Narushenie urodinamiki nizhnikh mochevykh putei i funktsii tazovogo dna u bol'nykh khronicheskim abakterial'nym prostatitom. Avtoref. dis. … kand. med. nauk. M., 2007. [Egorov A.A. Urodynamical dysfunction of lower urinary tracts and pelvic functions at patients with chronic abacterial prostatitis: Author,s abstract of thesis … of candidate of medical sciences. Moscow, 2007. (In Russ.)].
15. Davis S.N., Morin M., Binik Y.M. et al. Use of pelvic floor ultrasound to assess pelvic floor muscle function in urological chronic pelvic pain syndrome in men. J Sex Med 2011;8(11):3173–80.
16. Izvozchikov S.B. Nevospalitel'nyi sindrom khronicheskoi tazovoi boli u muzhchin: nevrologicheskie aspekty urologicheskoi problemy. Dis. … kand. med. nauk. M., 2007. [Izvozchikov S.B. Neurous inflammatory syndrome of the chronic pelvic pain at men: neurologic aspects of the urologic problem. Thesis … of candidate of medical sciences. Moscow, 2007. (In Russ.)].
17. Izvozchikov S.B. «Tazovaya bol' napryazheniya»: vzglyad nevrologa na problemu prostatodinii. Urologiya 2010;(3):68–70. [Izvozchikov S.B. “Pelvic pain strain”: neurologist,s vision of the prostalgia problem. Urologiya = Urology 2010;(3): 68–70. (In Russ.)].
18. Berger R.E., Ciol M.A., Rothman I., Turner J.A. Pelvic tenderness is not limited to the prostate in chronic prostatitis/chronic pelvic pain syndrome (CPPS) type IIIA and IIIB: comparison of men with and without CP/CPPS. BMC Urol 2007;7:17.
19. Izvozchikov S.B., Selitskii G.V., Kamchatnov P.R. Sindrom khronicheskoi tazovoi boli. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2011;111(5):71–4. [Izvozchikov S.B., Selitskiy G.V., Kamchatnov P.R. Chronic pelvic pain syndrome. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2011;111(5):71–4. (In Russ.)].
20. Schover L.R. Psychological factors in men with genital pain. Cleve Clin J Med 1990;57(8):697–700.
21. Pierce A.N., Christianson J.A. Stress and chronic pelvic pain. Prog Mol Biol Transl Sci 2015;131:509–35.
22. Berberich H.J., Ludwig M. Psychosomatische aspekte des chronischen beckenschmerzes. Urologe A 2004;43(3):254–60.
23. Kuznetskii Yu.Ya. Khronicheskii prostatit/sindrom khronicheskoi tazovoi boli kak psikhosomaticheskoe zabolevanie i ego ratsional'naya terapiya. Omskii nauchnyi vestnik 2006;(6):215–21. [Kuznetskiy Yu.Ya. Chronic prostatitis/ chronic pelvic pain syndrome as psychosomatic diseases and its rational therapy. Omskiy nauchnyy vestnik = Omsk Scientific Herald 2006;(6):215–21. (In Russ.)].
24. Mikhailichenko V.V., Aleksandrov V.P. Seksual'noe zdorov'e muzhchiny, reshenie delikatnoi problemy. SPb.: Nevskii prospekt, 2003. 160 s. [Mikhaylichenko V.V., Alexandrov V.P. Men, s sexual health, delicate problem solving. Saint Petersburg: Nevskiy Prospekt, 2003. 160 p. (In Russ.)].
25. Vakina T.N., Shutov A.M., Shalina S.V. i dr. Degidroepiandrosteron i polovaya funktsiya u muzhchin s khronicheskim prostatitom. Urologiya 2003;(1):49–51. [Vakina T.N., Shutov A.M., Shalina S.V. et al. Dehydroepiandrosterone and sexual function at men with chronic prostatitis. Urologiya = Urology 2003;(1):49–51. (In Russ.)].
26. Gonen M., Kalkan M., Cenker A., Ozkardes H. Prevalence of premature ejaculation in Turkish men with chronic pelvic pain syndrome. J Androl 2005;26(5):601–3.
27. Aubin S., Berger R.E., Heiman J.R., Ciol M.A. The association between sexual function, pain, and psychological adaptation of men diagnosed with chronic pelvic pain syndrome type III. J Sex Med 2008;5(3):657–67.
28. Kocharyan G.S. Seksual'nye disfunktsii u bol'nykh khronicheskim prostatitom: modeli formirovaniya. Zdorov'e muzhchiny 2012;(2):114–22. [Kocharyan G.S. Sexual dysfunctions at patients with chronic prostatitis: formation models. Zdorov,e muzhchiny = Men,s Health 2012;(2): 114–22. (In Russ.)].
29. Althof S.E., McMahon C.G., Waldinger M.D. et al. An update of the International Society of Sexual Medicine,s guidelines for the diagnosis and treatment of premature ejaculation (PE). J Sex Med 2014;11(6):1392–422.
30. Seyam R. A systematic review of the correlates and management of nonpremature ejaculatory dysfunction in heterosexual men. Ther Adv Urol 2013;5(5):254–97.
31. Chen X., Zhou Z.R., Qiu X.C. et al. The effect of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on Erectile function: a systematic review and metaanalysis. PLoS One 2015;10(10):1–13.
32. Tran C.N., Shoskes D.A. Sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. World J Urol 2013;31(4):741–6.
33. Riegel B., Bruenahl C.A., Ahyai S. et al. Assessing psychological factors, social aspects and psychiatric co-morbidity associated with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men – a systematic review. J Psychosom Res 2014;77(5): 333–50.
34. Mo M.Q., Long L.L., Xie W.L. et al. Sexual dysfunctions and psychological disorders associated with type IIIa chronic prostatitis: a clinical survey in China. Int Urol Nephrol 2014;46(12):2255–61.
35. Gavrilov V.E. Sindrom nevospalitel'noi khronicheskoi tazovoi boli u muzhchin – osobennosti kliniki, diagnostika i lechenie. Dis. … kand. med. nauk. M., 2005. [Gavrilov V.E. Syndrome of the non-inflammatory chronic pelvic pain at men – clinical peculiarities, diagnosis and treatment. Thesis … of candidate of medical sciences. Moscow, 2005. (In Russ.)].
36. Lopatkin H.A., Pugachev A.G., Apolikhin O.I. Urologiya. Pod red. N.A. Lopatkina. 5-e izd., pererab. i dop. M.: GEOTAR-MED, 2002. [Lopatkin N.A., Pugachev A.G., Apolikhin O.I. Urology. Ed. N.A. Lopatkin. 5th ed., revised and enlarged. Moscow: GEOTAR-MED, 2002. (In Russ.)].
37. Sivkov A.B., Oshchepkov V.N., Egorov A.A. Terapiya khronicheskogo abakterial'nogo neinfektsionnogo prostatita. V kn.: Sovremennye printsipy diagnostiki i lecheniya khronicheskogo prostatita: materialy plenuma pravleniya Rossiiskogo obshchestva urologov. M., 2004. S. 216–30. [Sivkov A.V., Oshchepkov V.N., Egorov A.A. Therapy of the chronic abacterial non-infectious prostatitis. In: Modern principles of diagnosis and treatment of the chronic prostatitis: materials of the board plenum of the Russian Urologists, Society. Moscow, 2004. Pp. 216–30. (In Russ.)].
38. Magistro G., Wagenlehner F.M., Grabe M. et al. Contemporary management of chronic prostatitis/chronic pelvic pain syndrome. Eur Urol 2016;69(2): 286–97.
39. Smirnov V.A. Lekarstvennaya terapiya khronicheskogo prostatita. FARMindeks-Praktik 2006;(6):46–55. [Smirnov V.A. Pharmaceutical therapy of the chronic prostatitis. FARMindeks-Praktik = PHARMindex-Practic 2006;(6):46–55. (In Russ.)].
40. Mazo E.B., Shkol'nikov M.E. Sindrom khronicheskoi tazovoi boli u muzhchin (obzor literatury). Consilium Medicum 2008;10(4):15–7. [Mazo E.B., Shkol,nikov M.E. Chronic pelvic pain syndrome at men (literature review). Consilium Medicum 2008;10(4):15–7. (In Russ.)].
41. Shalyapin I.V. Znachenie gemoreologicheskikh i gemostaticheskikh narushenii v patogeneze khronicheskogo prostatita. Dis. ... kand. med. nauk. Novosibirsk, 2001. [Shalyapin I.V. Meaning of hemoreologic dysfunctions and hemostatic diseases in the chronic prostatitis pathogenesis. Thesis … of candidate of medical sciences. Novosibirsk, 2001. (In Russ.)].
42. Schaeffer A.J., Weidner W., Barbalias G.A. Summary consensus statement: diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome. Eur Urol 2003;Suppl 2:1–4.
43. Mishra V.C., Browne J., Emberton M. Role of alpha-blockers in type III prostatitis: a systematic review of the literature. J Urol 2007;177(1):25–30.
44. Shaplygin L.V. Primenenie blokatorov al'fa1-adrenoretseptorov v urologicheskoi praktike. Voenno-meditsinskii zhurnal 2007;(7):16–9. [Shaplygin L.V. Application of blockers of alpha1-adrenoreceptors in the urologic practice. Voenno-meditsinskiy zhurnal = Military Medical Journal 2007;(7):16–9. (In Russ.)].
45. Anderson R.U., Wise D., Sawyer T., Chan C. Integration of myofascial trigger point release and paradoxical relaxation training treatment of chronic pelvic pain in men. J Urol 2005;174(1): 155–60.
46. Pereverzev A.S. Khronicheskii tazovyi bolevoi sindrom v urologii. Novosti meditsiny i farmatsii. Urologiya i nefrologiya 2008;(258). [Pereverzev A.S. Chronic pelvic pain syndrome in urology. Novosti meditsiny i farmatsii. Urologiya i nefrologiya = News ofMedicine andPharmacy. Urology and Nephrology 2008;(258).(In Russ.)].
47. Vein A.M., Voznesenskaya T.G., Golubev V.L., Dyukova G.M. Depressiya v nevrologicheskoi praktike. M.: MIA, 2007. 208 s. [Veyn A.M., Voznesenskaya T.G., Golubev V.L., Dukova G.M. Depression in the neurologic practice. Moscow: MIA, 2007. 208 p. (In Russ.)].
48. Selitskii G.V., Kaprin A.D., Izvozchikov S.B. i dr. Milnatsipran (iksel) v lechenii trevozhno-depressivnykh i seksual'nykh rasstroistv u bol'nykh s nevospalitel'nym sindromom khronicheskoi tazovoi boli. Terapevticheskii arkhiv 2007;(5):81–4. [Selitskiy G.V., Kaprin A.D., Izvozchikov S.B. et al. Milnacipran (ixel) in the treatment of anxiety and depressive disorders at patients with noninflammatory syndrome of the chronic pelvic pain. Terapevticheskiy arkhiv = Therapeutic Archive 2007;(5):81–4. (In Russ.)].
49. Pushkar' D.Yu., Yudovskii S.O., Tevlin K.P. Erektil'naya disfunktsiya: sovremennye vozmozhnosti medikamentoznoi terapii. Ukraїns'kii terapevtichnii zhurnal 2005;(3):84–8. [Pushkar, D.Yu.,
50. Yudovskiy S.O., Tevlin K.P. Erectile dysfunction: modern possibilities of the pharmaceutical therapy. Ukrainskiy terapevtichniy zhurnal = Ukrainian Therapeutic Journal 2005;(3):84–8.(In Ukr.)].
